Journals / Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi / 2021 / Cilt: 16 - Sayı: 2

The neuroprotective effect of Coconut Oil in mice with Traumatic Brain Injury

Hindistan Cevizi Yağının Travmatik Beyin Hasarı Olan Farelerde Nöroprotektif Etkisi

Pages
236–240
Publication Date
2021-07-07
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Our findings have supported that coconut oil has a potential neuroprotective effect on damaged neurons after traumatic brain injury in mice.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: This study aimed to evaluate the possible neuroprotective effect of coconut oil in mice with traumatic brain injury.
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Key Findings & Data:Materials and Methods: Mice were randomly divided into two groups (n=5 per group); namely, the control and coconut oil groups, which were administered 250 µl saline and 10 mg/kg body weight per os coconut oil along a week, respectively, before cold brain injury.
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Conclusion & Impact:Conclusion: Our findings have supported that coconut oil has a potential neuroprotective effect on damaged neurons after traumatic brain injury in mice.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:beyin hasarı · hindistan cevizi yağı · nöroproteksiyon

Abstract

Aim: This study aimed to evaluate the possible neuroprotective effect of coconut oil in mice with traumatic brain injury. Materials and Methods: Mice were randomly divided into two groups (n=5 per group); namely, the control and coconut oil groups, which were administered 250 µl saline and 10 mg/kg body weight per os coconut oil along a week, respectively, before cold brain injury. Infarction and edema volume in the brain was measured with cresyl violet in two groups on the eighth day, 24 hours after injury. Results: Our data indicated a statistically significant decrease in the infarct and oedema volumes after coconut oil application. Conclusion: Our findings have supported that coconut oil has a potential neuroprotective effect on damaged neurons after traumatic brain injury in mice.

Özet

Amaç: Bu çalışmada hindistan cevizi yağının travmatik beyin hasarı olan farelerde olası nöroprotektif etkisini değerlendirmeyi amaçladık. Materyal ve Metod: Fareler rastgele iki gruba ayrıldı (grup başına n = 5); diğer bir deyişle, kontrol ve Hindistan cevizi yağı grubu; sırasıyla soğuk beyin hasarından önce bir hafta boyunca 250 ul salin ve her bir os hindistancevizi yağı başına 10 mg / kg vücut ağırlığına göre belirlendi. Beyindeki enfarktüs ve ödem hacmi yaralanmadan 24 saat sonra sekizinci günde iki grupta Kresil Moru ile ölçüldü. Bulgular: Verilerimiz, hindistancevizi yağı uygulamasından sonra enfarktüs ve ödem hacimlerinde istatistiksel olarak anlamlı bir düşüş olduğunu gösterdi. Sonuç: Bulgularımız, hindistancevizi yağının farelerde travmatik beyin hasarı sonrası hasarlı nöronlar üzerinde potansiyel bir nöroprotektif etkiye sahip olduğunu desteklemiştir.

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Cite This Article

ÇANKAYA, Ş., GÜNAL, M. Y., BEKER, M. Ç., ÇAĞLAYAN, A. B., ÖZDEMİR, E. M., SAATCİ, Ö., ÇANKAYA, B., YULUĞ, B. (2021). The neuroprotective effect of Coconut Oil in mice with Traumatic Brain Injury. Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi, Cilt: 16 - Sayı: 2, 236–240. https://ajindex.com/articles/783230

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References (1)

  1. Fernando WMADB, Martins IJ, Goozee K, Brennan CS, Jayasena V, Martins RN. The role of dietary coconut for the prevention and treatment of Alzheimer's disease: potential mechanisms of action. Br J Nutr. 2015;114(1):1-14.