Protective Effect of Metformin Alone or in Combination with Valproic acid on Pentylenetetrazole-Induced Seizures in Mice

References (11)

1. Maiha BB, Magaji MG, Yaro AH, Hamza AH, Ahmed SJ, Magaj AR. Anticonvulsant studies on Cochlospermum tinctorium and Paullinia pinnata extracts in laboratory animals. Nig J Pharm Sci 2009;8:102-108.
2. Carpio A, Hauser WA. Epilepsy in the developing world. Curr Neurol Neurosci Rep 2009;9:319-326.
3. Curia G, Lucchi C, Vinet J, Gualtieri F, Marinelli C, Torsello A et al. Pathophysiogenesis of mesial temporal lobe epilepsy: is prevention of damage antiepileptogenic? Curr.Med.Chem 2014;21:663-688.
4. Akkaya R, Gümüş E, Akkaya B, Karabulut S, Gülmez K, Karademir M et al. Wi-Fi decreases melatonin protective effect and increases hippocampal neuronal damage in pentylenetetrazole induced model seizures in rats. Pathophysiology 2019;26:375-379.
5. Tastemur Y, Gumus E, Ergul M, Ulu M, Akkaya R, Ozturk A et al. Positive effects of angiotensin-converting enzyme (ACE) inhibitor, captopril, on pentylenetetrazole-induced epileptic seizures in mice. Trop J Pharm Res 2020;19:637-643.
6. Thom M, Zhou J, Martinian L, Sisodiya S. Quantitative post‐mortem study of the hippocampus in chronic epilepsy: Seizures do not inevitably cause neuronal loss. Brain 2005;128:1344–1357.
7. Sato H, Takahashi T, Sumitani K, Takatsu H, Urano S. Glucocorticoid generates ROS to induce oxidative injury in the hippocampus, leading to impairment of cognitive function of rats. J Clin Biochem Nutr 2010;47:224-232.
8. Lim DW, Park J, Jung J, Kim SH, Um MY, Yoon M et al. Dicaffeoylquinic acids alleviate memory loss via reduction of oxidative stress in stress-hormone-induced depressive mice. Pharmacol Res 2020;161:105252. Davidson MB, Peters AL. An overview of metformin in the treatment of type 2 diabetes mellitus. Am J Med 1997;102:99-110.
9. Cheng YY, Leu HB, Chen TJ, Chen CL, Kuo CH, Lee SD et al. Metformin-inclusive therapy reduces the risk of stroke in patients with diabetes: A 4-year follow-up study. J Stroke Cerebrovasc Dis 2014;23:99-105.
10. Thangthaeng N, Rutledge M, Wong JM, Vann PH, Forster MJ, Sumien N. Metformin impairs spatial memory and visual acuity in old male mice. Aging Dis 2017;8:17-30.
11. Labuzek K, Liber S, Gabryel B, Okopień B. Metformin has adenosine-monophosphate activated protein kinase (AMPK)-independent effects on LPS-stimulated rat primary microglial cultures. Pharmacol Rep 2010;62:827-848. Tasci I. Metformin: good or bad for the brain? Ann Transl Med 2014;6:53. Moore EM, Mander AG, Ames D, Kotowicz MA, Carne RP, Brodaty H et al. Increased risk of cognitive impairment in patients with diabetes is associat