The interactions between the PILs and supercoiled PBR322 DNA were also scrutinized, and it was determined that they exhibited significant conformational changes.
📌 3 Key Takeaways
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Objective & Hypothesis:The protic ionic liquids (PILs) (3a-3d) were synthesized from the reactions of tetraamino-4-(fluorobenzyl)spiro(N/O)cyclotriphosphazenes (2a-2d) with the gentisic acid in THF.
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Key Findings & Data:The structures of the PILs were verified by elemental analyses, Fourier transform infrared (FTIR), 1H, 13C {1H} and 31P {1H} NMR techniques.
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Conclusion & Impact:The interactions between the PILs and supercoiled PBR322 DNA were also scrutinized, and it was determined that they exhibited significant conformational changes.
The protic ionic liquids (PILs) (3a-3d) were synthesized from the reactions of tetraamino-4-(fluorobenzyl)spiro(N/O)cyclotriphosphazenes (2a-2d) with the gentisic acid in THF. The structures of the PILs were verified by elemental analyses, Fourier transform infrared (FTIR), 1H, 13C {1H} and 31P {1H} NMR techniques. The thermal properties of the PILs were evaluated using TG/DTG/DTA instrument. On the other hand, the antimicrobial activities of the PILs were examined against some bacteria and fungi, and the obtained results were compared with the evaluations of the corresponding fully substituted cyclotriphosphazene bases. The interactions between the PILs and supercoiled PBR322 DNA were also scrutinized, and it was determined that they exhibited significant conformational changes.
ELMAS, G., OKUMUŞ, A., Kılıç, Z., Çelik, S. P., Açık, L. (2017). The Spectroscopic and Thermal Properties, Antimicrobial Activities and DNA Interactions of 4-(Fluorobenzyl)Spiro(N/O) Cyclotriphosphazenium Salts. Journal of the Turkish Chemical Society Section A: Chemistry, Cilt: 4 - Sayı: 3, 993–1016. https://ajindex.com/articles/781540
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