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Journals / Journal of the Turkish Chemical Society Section A: Chemistry / 2021 / Cilt: 8 - Sayı: 2

Quercetin particles with lower inhibitory activity for α-glycosidase and negligible effects on blood clotting

Mehtap ŞAHİNER
Selin SAGBAS SUNER
Pages
443–452
Publication Date
2021-05-31
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The fluorescence spectroscopy of QR and p(QR) in fibrinogen showed that p(QR) particles do not induce clothing of blood.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Poly(quercetin) (p(QR)) particles was synthesis by using poly(ethylene glycol) diglycidyl ether (PEGGE) crosslinker in a single step via microemulsion system.
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Key Findings & Data:P(QR) particles were found to be in spherical shape with 372±9 nm size range by means of SEM images and DLS measurements.
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Conclusion & Impact:The fluorescence spectroscopy of QR and p(QR) in fibrinogen showed that p(QR) particles do not induce clothing of blood.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Quercetin particles · alpha glucosidase inhibitor · fibrinogen binding

Abstract

Poly(quercetin) (p(QR)) particles was synthesis by using poly(ethylene glycol) diglycidyl ether (PEGGE) crosslinker in a single step via microemulsion system. The morphological, size and functional analysis of the prepared particles were carried by optic microscope, scanning electron microscope (SEM), dynamic light scattering (DLS) measurements and FT-IR spectroscopy. P(QR) particles were found to be in spherical shape with 372±9 nm size range by means of SEM images and DLS measurements. The zeta potential measurements, performed at different pH conditions and potentiometric titration of p(QR) particles were revealed that the isoelectric point and pKa values of as around pH 2.5 and 2.3, respectively. Ferric reducing antioxidant power (FRAP) was determined for QR and p(QR) particles at pH 3.6 and found as 9.4 and 0.43 µg reduced Fe(ll). The effects of QR and p(QR) particles on alfa-glycosidase enzyme activity at pH 6.9 were investigated and found that QR molecules and p(QR) particles were capable of inhibiting the α-glycosidase enzyme 89.3% and 24.7% respectively. The fluorescence spectroscopy of QR and p(QR) in fibrinogen showed that p(QR) particles do not induce clothing of blood.

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Cite This Article

ŞAHİNER, M., SUNER, S. S. (2021). Quercetin particles with lower inhibitory activity for α-glycosidase and negligible effects on blood clotting. Journal of the Turkish Chemical Society Section A: Chemistry, Cilt: 8 - Sayı: 2, 443–452. https://ajindex.com/articles/781126

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