SavedAdd your journal

Journals / Journal of Surgery and Medicine / 2021 / Cilt: 5 - Sayı: 1

The relationship between vitamin 25(OH)D level and hematological parameters in newly diagnosed women with fibromyalgia syndrome

İlknur AYKURT KARLIBEL
Hakan DEMİRCİ
Meliha KASAPOĞLU
Deniz AZKAN TÜRE
Lale ALTAN
Pages
61–65
Publication Date
2021-01-01
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: VitD deficiency may be a risk factor for FMS (cut-off is

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Background/Aim: Chronic inflammation may play a role in the pathogenesis of fibromyalgia syndrome (FMS).
📊
Key Findings & Data:Methods: The prospective case-control study included 90 newly diagnosed female patients with FMS (group 1) and 90 healthy volunteers (group 2).
💡
Conclusion & Impact:Conclusion: VitD deficiency may be a risk factor for FMS (cut-off is
🔬Design:Survey & Empirical Study
📍Scope:Comprehensive Sample
⚙️Variables:fibromyalgia · inflammation · platelet activation

Abstract

Background/Aim: Chronic inflammation may play a role in the pathogenesis of fibromyalgia syndrome (FMS). Several hematological markers are prothrombotic, and markers of systemic inflammation. Vitamin D (VitD) level can affect FMS and has an anti-inflammatory effect. The aim of this study is to investigate the relationship between hematological parameters and VitD in FMS and its effect on disease severity. Methods: The prospective case-control study included 90 newly diagnosed female patients with FMS (group 1) and 90 healthy volunteers (group 2). Pain and fatigue were evaluated by visual analogue scale (VAS). Disease severity was evaluated by FMS Impact Questionnaire (FIQ) in FMS. Neutrophils, lymphocytes, platelets, platelet distribution width (PDW) and mean platelet volume (MPV) were obtained from complete blood count results in both groups. Neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) were calculated. 25(OH)D concentration was measured. Patients were divided into 3 groups according to vitamin D levels (VitD 30 ng/ml.) Results: The mean MPV and vitamin D levels were significantly higher in group 2 (P=0.001, P0.05). There was a significant inverse relationship between FIQ and PLR (P=0.022). Conclusion: VitD deficiency may be a risk factor for FMS (cut-off is

🔖

Cite This Article

KARLIBEL, İ. A., DEMİRCİ, H., KASAPOĞLU, M., TÜRE, D. A., ALTAN, L. (2021). The relationship between vitamin 25(OH)D level and hematological parameters in newly diagnosed women with fibromyalgia syndrome. Journal of Surgery and Medicine, Cilt: 5 - Sayı: 1, 61–65. https://ajindex.com/articles/780114

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (14)

  1. Clauw DJ. Fibromyalgia: a clinical review. JAMA. 2014 Apr 16;311(15):1547-55
  2. Bennett RM, Russell J, Cappelleri JC, Bushmakin AG, Zlateva G, Sadosky A. Identification of symptom and functional domains that fibromyalgia patients would like to see improved: a cluster analysis. BMC Musculoskelet Disord. 2010 Jun 28; 11:134
  3. Berssaneti AA, Matsutani LA, Yuan SLK, et al. Prevalence of fibromyalgia: literature review update. Rev Bras Reumatol Engl Ed. 2017 57(4):356-363
  4. Coskun Benlidayi. Role of inflammation in the pathogenesis and treatment of fibromyalgia. Rheumatol Int. 2019;39(5):781-91
  5. Akturk S, Buyukavci R. Evaluation of blood neutrophil-lymphocyte ratio and platelet distribution width as inflammatory markers in patients with fibromyalgia. Clin Rheumatol. 2017;36(8):1885–9
  6. Al-Nimer MSM, Mohammad TAM. Correlation of hematological indices and ratios derived from them with FIQR scores in fibromyalgia. Pak J Med Sci. 2018;34(5):1219–24
  7. Çintesun E, Akar S, Gul A, Çintesun FNI, Sahin G, Ezveci H, et al. Subclinical inflammation markers in hyperemesis gravidarum and ketonuria: A case-control study. J Lab Physicians. 2019;11(2):149-53
  8. Çetin MS, Özcan Çetin EH, Akdı A, Aras D, Topaloğlu S, Temizhan A, et al. Platelet distribution width and plateletcrit: novel biomarkers of ST elevation myocardial infarction in young patients. Kardiol Pol. 2017;75(10):1005-12
  9. Haliloğlu S, Carlioglu A, Sahiner E, Karaaslan Y, Kosar A. Mean platelet volume in patients with fibromyalgia. Z Rheumatol. 2014;73(8):742-5
  10. Molina F, Del Moral ML, La Rubia M, Blanco S, Carmona R, Rus A. Are patients with fibromyalgia in a prothrombotic state? Biol Res Nurs. 2019;21(2):224-30
  11. Baeke F, Gysemans C, Korf H, Mathieu C. Vitamin D insufficiency: implications for the immune system. Pediatr Nephrol. 2010;25:1597-606
  12. Çidem M, Karacan İ, Beytemur O, Kara S. Prevalence and risk factors for vitamin D deficiency in patients with widespread musculoskeletal pain. Turk J Med Sci. 2017 12;47(3):728-31
  13. Kiani A, Mohamadi-Nori E, Vaisi-Raygani A, Tanhapour M, Elahi-Rad S, et al. Vitamin D-binding protein, and vitamin D receptor genotypes and 25-hydroxyvitamin D levels are associated with development of aortic and mitral valve calcification and coronary artery diseases. Mol Biol Rep. 2019;29
  14. Verdoia M, Pergolini P, Nardin M, Rolla R, Negro F, Kedhi E. Vitamin D levels and platelet reactivity in diabetic patients receiving dual antiplatelet therapy. Vascul P