Journals / Journal of Surgery and Medicine / 2021 / Cilt: 5 - Sayı: 2

Could eosinophil chemotactic factor (CCL11) be a useful biomarker of Covid-19?

Pages
168–173
Publication Date
2021-02-01
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Eosinophil counts of the patients on admission (EO1) were significantly lower than those of the controls and one-week later EO2 levels (P

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Background/Aim: Differentiating COVID-19 positive patients from negative ones with similar symptoms and predicting the course of disease are major problems in COVID-19.
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Key Findings & Data:For this purpose, we investigated the performance of Eosinophil Chemotactic Factor (CCL11) in COVID-19 and compared complete blood count parameters and indexes.
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Conclusion & Impact:Eosinophil counts of the patients on admission (EO1) were significantly lower than those of the controls and one-week later EO2 levels (P
🔬Design:Research Article
📍Scope:2020 Verileri
⚙️Variables:Covid-19 · ECF · CCL11

Abstract

Background/Aim: Differentiating COVID-19 positive patients from negative ones with similar symptoms and predicting the course of disease are major problems in COVID-19. For this purpose, we investigated the performance of Eosinophil Chemotactic Factor (CCL11) in COVID-19 and compared complete blood count parameters and indexes. Methods: In this retrospective case-control study, ECF/CCL11 values, as well as the clinical, laboratory and radiological data of thirty patients who were diagnosed with Covid-19 between 15 March-15 June 2020 were compared with those of thirty healthy controls. Results: Both patients and controls included 10 (33.30%) females and 20 (66.60%) males with a mean age of 57.2 (15.46) and 60.07 (20.59) years, respectively. Eosinophil counts of the patients on admission (EO1) were significantly lower than those of the controls and one-week later EO2 levels (P

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Cite This Article

KATAR, M. (2021). Could eosinophil chemotactic factor (CCL11) be a useful biomarker of Covid-19?. Journal of Surgery and Medicine, Cilt: 5 - Sayı: 2, 168–173. https://ajindex.com/articles/780077

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References (15)

  1. Zhou P, Yang X-L, Wang X-G, Hu B, Zhang L, Zhang W, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020;579(7798):270-3
  2. Paules CI, Marston HD, Fauci AS. Coronavirus infections—more than just the common cold. Jama. 2020;323(8):707-8
  3. Erickson MA, Morofuji Y, Owen JB, Banks WA. Rapid transport of CCL11 across the blood-brain barrier: regional variation and importance of blood cells. Journal of Pharmacology and Experimental Therapeutics. 2014;349(3):497-507
  4. Rothenberg ME, Hogan SP. The eosinophil. Annual review of immunology. 2006;24
  5. Nakayama T, Hirahara K, Onodera A, Endo Y, Hosokawa H, Shinoda K, et al. Th2 cells in health and disease. Annual review of immunology. 2017;35:53-84
  6. Lambrecht BN, Hammad H. The immunology of asthma. Nature immunology. 2015;16(1):45-56
  7. Blanchard C, Rothenberg ME. Biology of the eosinophil. Advances in immunology. 2009;101:81-121
  8. Kitaura M, Nakajima T, Imai T, Harada S, Combadiere C, Tiffany HL, et al. Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3. Journal of Biological Chemistry. 1996;271(13):7725-30
  9. Rankin SM, Conroy DM, Williams TJ. Eotaxin and eosinophil recruitment: implications for human disease. Molecular medicine today. 2000;6(1):20-7
  10. Du Y, Tu L. Clinical Features of 85 Fatal Cases of COVID-19 from Wuhan. A Retrospective Observational Study. 2020;201(11):1372-9. doi: 10.1164/rccm.202003-0543OC. PubMed PMID: 32242738
  11. Yao X, Zeng Y, Tong Y, Tang X, Yin Z. Determination and analysis of blood eosinophil in 200 severe acute respiratory syndrome patients. Lab Med. 2004;5(19):444-5
  12. Li Q, Ding X, Xia G, Chen H-G, Chen F, Geng Z, et al. Eosinopenia and elevated C-reactive protein facilitate triage of COVID-19 patients in fever clinic: a retrospective case-control study. E Clinical Medicine. 2020:100375
  13. Li X, Xu S, Yu M, Wang K, Tao Y, Zhou Y, et al. Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan. Journal of Allergy and Clinical Immunology. 2020
  14. Jose P, Griffiths-Johnson D, Collins P, Walsh D, Moqbel R, Totty N, et al. Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation. The Journal of experimental medicine. 1994;179(3):881-7
  15. Van Coillie E, Van Damme J, Opdenakker G. The MCP/eotaxin subfamily of CC chemokines. Cytokin