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Journals / Journal of Ongoing Chemical Research / 2018 / Cilt: 3 - Sayı: 2

SYNTHESIS AND CHARACTERIZATION OF SOME NEW HYDRAZONES WITH ANTI‐UREASE ACTIVITIES

Yusuf SICAK
Pages
71–74
Publication Date
2018-06-01
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This study has culminated in the identiŞcation of some compoundswhich can serve as leads for new potent urease inhibitors

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Hydrazones were considered as signiŞcant substrates in drug discovery process.
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Key Findings & Data:Therefore, a seriesof some new 1- 4- 1- 2- 4-substitutedphenyl hydrazono ethyl phenyl -3- 4-nitrophenyl ureaderivatives were synthesized as potential urease inhibitory agents.
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Conclusion & Impact:This study has culminated in the identiŞcation of some compoundswhich can serve as leads for new potent urease inhibitors
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:organic synthesis · Urease inhibition activity · Hydrazone

Abstract

Hydrazones were considered as signiŞcant substrates in drug discovery process. Therefore, a seriesof some new 1- 4- 1- 2- 4-substitutedphenyl hydrazono ethyl phenyl -3- 4-nitrophenyl ureaderivatives were synthesized as potential urease inhibitory agents. The synthesizedcompounds were characterized by FTIR, ¹H NMR, 13C NMR, and elemental analysis C, H, N . Allcompounds were evaluated in vitro for urease inhibitory potential. Among synthesized compounds,8, 7, 6, and 4 showed excellent activities IC50 i.e. 10.13±0.40, 12.15±0.22, 17.81±0.36, and22.95±0.47 µM, respectively. This study has culminated in the identiŞcation of some compoundswhich can serve as leads for new potent urease inhibitors

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Cite This Article

SICAK, Y. (2018). SYNTHESIS AND CHARACTERIZATION OF SOME NEW HYDRAZONES WITH ANTI‐UREASE ACTIVITIES. Journal of Ongoing Chemical Research, Cilt: 3 - Sayı: 2, 71–74. https://ajindex.com/articles/778194

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