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Journals / Journal of Health Sciences and Medicine / 2022 / Cilt: 5 - Sayı: 1

Alteration of cerebral perfusion and cortical thickness in depression episodes: a comparative MRI study

Özkan KILINÇ
Mustafa HIZAL
Özden ARISOY
Nur ÖZGEDİK
Oya KALAYCIOĞLU
Pages
38–44
Publication Date
2022-01-17
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: These findings suggests that cortical atrophy and activation of default mode network in recurrent episodes which leads to decreased response to treatment.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: We aimed to determine the difference between cerebral perfusion and cortical thickness between first attack and recurrent in major depression patients.
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Key Findings & Data:Material and Method: Our study was conducted prospectively between 01.03.2017-03.03.2018 in Izzet Baysal University Psychiatry department. 40 patients (21 first episodes and 19 recurrent episodes) diagnosed with depression according to DSM 5 by the American Psychiatric Association and a control group of 16 healthy individuals were evaluated for cerebral blood flow and cortical thickness with Perfusion MRI.
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Conclusion & Impact:Conclusion: These findings suggests that cortical atrophy and activation of default mode network in recurrent episodes which leads to decreased response to treatment.
🔬Design:Research Article
📍Scope:2017 Verileri
⚙️Variables:Depression · Cerebral perfusion · Cortical thickness

Abstract

Aim: We aimed to determine the difference between cerebral perfusion and cortical thickness between first attack and recurrent in major depression patients. Material and Method: Our study was conducted prospectively between 01.03.2017-03.03.2018 in Izzet Baysal University Psychiatry department. 40 patients (21 first episodes and 19 recurrent episodes) diagnosed with depression according to DSM 5 by the American Psychiatric Association and a control group of 16 healthy individuals were evaluated for cerebral blood flow and cortical thickness with Perfusion MRI. Patients were also evaluated by Hamilton depression rating scale. Findings: The cortical thickness was significantly decreased in recurrent attacks.There was no significant difference of CBF in first episode and recurrent episodes, except cingulate cortex, which showed significantly reduced CBF values in recurrent group. In patients with higher Hamilton depression scale points, the CBF values of insular cortex were decreased. Conclusion: These findings suggests that cortical atrophy and activation of default mode network in recurrent episodes which leads to decreased response to treatment.

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Cite This Article

KILINÇ, Ö., HIZAL, M., ARISOY, Ö., ÖZGEDİK, N., KALAYCIOĞLU, O. (2022). Alteration of cerebral perfusion and cortical thickness in depression episodes: a comparative MRI study. Journal of Health Sciences and Medicine, Cilt: 5 - Sayı: 1, 38–44. https://ajindex.com/articles/776641

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