Results: There was a statistically significant difference between the groups in terms of NLR and SII index values (p
📌 3 Key Takeaways
🎯
Objective & Hypothesis:Introduction: The relationship between inflammation and atherosclerosis and ischemic stroke was shown in studies, and we aimed to evaluate the relationship between the systemic immune-inflammation (SII) index and carotid artery stenosis (CAS) in our study.
📊
Key Findings & Data:Material and Method: Forty patients with CAS with acute cerebrovascular disease and sixty three patients without CAS with acute cerebrovascular disease were included in the study.
💡
Conclusion & Impact:Results: There was a statistically significant difference between the groups in terms of NLR and SII index values (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Carotid artery stenosis · inflammation · systemic immune-inflammation index
Abstract
Introduction: The relationship between inflammation and atherosclerosis and ischemic stroke was shown in studies, and we aimed to evaluate the relationship between the systemic immune-inflammation (SII) index and carotid artery stenosis (CAS) in our study. Material and Method: Forty patients with CAS with acute cerebrovascular disease and sixty three patients without CAS with acute cerebrovascular disease were included in the study. Demographic characteristics, neutrophil/lymphocyte ratio ( NLR), and the SII indexes of the patients were compared between the groups with and without CAS. Results: There was a statistically significant difference between the groups in terms of NLR and SII index values (p
GÖLEN, M. K., OKUYAN, D. Y. (2022). Is the systemic immune-inflammation index a predictive marker of carotid artery stenosis?. Journal of Health Sciences and Medicine, Cilt: 5 - Sayı: 2, 652–658. https://ajindex.com/articles/776623
Feigin VL, Krishnamurthi RV, Parmar P, et al. Update on teh Global Burden of ischemic and Hemorrhagic Stroek in 1990-2013 The GBD 2013 Study. Neuroepidomiology 2015; 45: 161-76.
Liapis CD, Bell PR, Mikhailidis D, et al, ESVS Guidelines Collaborators. ESVS guidelines. Invasive treatment for carotid stenosis: indications, techniques. Eur J Vasc Endovasc Surg 2009; 37: 1-19. Flaherty ML,Kissela B, Khoury JC et al. Carotid artery stenosis as a cause of stroke. Neuroepidomyology 2013; 40: 36-41.
Espinola-Klein C, Rupprecht HJ, Blankenberg S, et al. Athero Gene Investigators. Impact of infectious burden on extent and long-term prognosis of atherosclerosis. Circulation 2002; 105: 15-21.
Utku U, Çelik Y.İnmede etyoloji sınıflandırma ve risk faktörleri Serebrovasküler Hastalıklar Güneş Tıp Yayınevi 2009 S: 51-62.
Boehme AK, Esenwa C, Elkind MS. Stroke Risk Factors, Genetics, and Prevention.Circ Res 2017; 120: 472-95.
Jander S, Sitzer M, Schumann R, et al. Inflammation in high-grade carotid stenosis: a possible role for macrophages and T cells in plaque destabilization. Stroke 1998; 29: 1625-30.
Anderson JL, Carlquist JF, Muhlestein JB, Horne BD, Elmer SP. Evaluation of C-reactive protein, an inflammatory marker, and infectious serology as risk factors for coronary artery disease and myocardial infarction. J Am Coll Cardiol 1998; 32: 35-41.
Darbousset R, Thomas GM, Mezouar S, et al. Tissue factor-positive neutrophils bind to injured endothelial wall and initiate thrombus formation. Blood 2012; 120: 2133-43.
Arvin B, Neville LF, Barone FC, Feuerstein GZ. The rol of inflamation and cytokines in brain injury. Neurosci Biobehav Rev 1996: 20: 445-52.
Ridker PM, Hennekens CH, Buring JE, Rifai N. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med 2000; 342: 836-43.
Emerging Risk Factors Collaboration, Kaptoge S, Di Angelantonio E, Lowe G et al. C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis. Lancet 2010; 375: 132-40.
Zhou Y, Han W, Gong D, Man C, Fan Y. Hs-crp in stroke: a meta-analysis. Clinica Chimica Acta; Int J Clin Chem 2016; 453: 21–7.
Wang L, Song Q, Wang C et al. Neutrophil to lymphocyte ratio predicts poor outcomes after acute ischemic stroke: A cohort study and systematic review. J Neurol Sci 2019; 406: 116445. Fest J, Ruiter R, Ikram MA, Voortman T, van Eijck CHJ, Stricker BH. Reference values for white blood-