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Journals / Journal of Health Sciences and Medicine / 2022 / Cilt: 5 - Sayı: 5

Concordance of histopathological and radiological grading in soft tissue sarcomas

Begumhan BAYSAL
Fikret Berkan ANARAT
Mahmut Bilal DOGAN
Tulay ZENGİNKİNET
Aykut CELİK
Ayse Nur TOKSOZ
Tarık SARI
Korhan ÖZKAN
Pages
1484–1490
Publication Date
2022-09-25
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

On MRI examinations, the absence of necrosis was significantly associated with FNCLCC grade 1 and a low Ki-67 index (p

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: The grade of the tumor is essential for planning the treatment strategy in soft-tissue sarcomas (STS).
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Key Findings & Data:Material and Method: This retrospective single-center study involved preoperative contrast-enhanced MRI examinations of 64 patients with STS.
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Conclusion & Impact:On MRI examinations, the absence of necrosis was significantly associated with FNCLCC grade 1 and a low Ki-67 index (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Magnetic resonance imaging · FNCLCC grading · soft-tissue sarcoma

Abstract

Aim: The grade of the tumor is essential for planning the treatment strategy in soft-tissue sarcomas (STS). The goal of this study is to determine magnetic resonance imaging features related to histopathological grade and aggressiveness of STS. Material and Method: This retrospective single-center study involved preoperative contrast-enhanced MRI examinations of 64 patients with STS. MRI findings evaluated were; heterogeneity, necrosis, hemorrhage, and relationship with surrounding tissue in T1-weighted (T1W), T2-weighted (T2W), and T1W post-contrast sequences of the lesion. Histological grade was determined with the Fédération Nationale des Centres de Lutte Contre Le Cancer (FNCLCC) grading system, and the aggressiveness of the lesion was measured with the Ki-67 index. Results: Sixty-four patients (mean age 45.5±21.6, M/F ratio 34/30) with STS were included. 33 (51.6%) patients graded as FNCLCC grade 3. On MRI examinations, the absence of necrosis was significantly associated with FNCLCC grade 1 and a low Ki-67 index (p

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Cite This Article

BAYSAL, B., ANARAT, F. B., DOGAN, M. B., ZENGİNKİNET, T., CELİK, A., TOKSOZ, A. N., SARI, T., ÖZKAN, K. (2022). Concordance of histopathological and radiological grading in soft tissue sarcomas. Journal of Health Sciences and Medicine, Cilt: 5 - Sayı: 5, 1484–1490. https://ajindex.com/articles/776483

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