SavedAdd your journal

Journals / Eurasian Journal of Food Science and Technology / 2021 / Cilt: 5 - Sayı: 2

Gastroprotective and Antioxidant Effects of the Cinnamon, Cumin, Sumac on Indomethacin Induced Gastric Ulcer in Rats

Özlem AYDIN BERKTAŞ
Fehmi ODABASOGLU
Fadime ATALAY DUMLU
Zerrin KUTLU
Elif ÇADIRCI
Mesut HALICI
Fazlı ÖZTÜRK
Ahmet ÇAKIR
Pages
147–166
Publication Date
2021-12-31
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

It is claimed by the measured enzyme activity differences that these spices have antiulcerogenic activity.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The gastro-protective effect of water extracts spice of cinnamon, cumin and sumac in indomethacin induced ulcer model in rats was investigated, in vivo and biochemical mechanism of spice extracts were monitored by measuring their antioxidant.
📊
Key Findings & Data:For each cumin, cinnamon and sumach extracts 50, 100, 200 and 400 mg/kg, positive control famotidine (FAM) 25 mg/kg and negative control indomethacin (IND) 25 mg/kg dosage form was orally administered.
💡
Conclusion & Impact:It is claimed by the measured enzyme activity differences that these spices have antiulcerogenic activity.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Antioxidant · cinnamon · cumin

Abstract

The gastro-protective effect of water extracts spice of cinnamon, cumin and sumac in indomethacin induced ulcer model in rats was investigated, in vivo and biochemical mechanism of spice extracts were monitored by measuring their antioxidant. For each cumin, cinnamon and sumach extracts 50, 100, 200 and 400 mg/kg, positive control famotidine (FAM) 25 mg/kg and negative control indomethacin (IND) 25 mg/kg dosage form was orally administered. After that catalase (CAT), superoxide dismutase (SOD), myeloperoxidase (MPx) enzyme activities and glutathione (GSH), lipid perxidase (LPO) amounts were measured. In IND induced ulcer group, It is determined that each four dosage form of spices and positive control FAM group significantly decreased the ulcer area (p<0.05). In addition to this, CAT, SOD, MPx enzyme activities and GSH, LPO amounts were measured in spice extract administered gastric damaged rat stomach tissues in order to explain the effects of antioxidant defense system on antiulcerogenic activity. In IND induced tissues, while LPO, MPx and CAT increased GSH and SOD decreased with respect to the (healthy) control group. It is claimed by the measured enzyme activity differences that these spices have antiulcerogenic activity.

🔖

Cite This Article

BERKTAŞ, Ö. A., ODABASOGLU, F., DUMLU, F. A., KUTLU, Z., ÇADIRCI, E., HALICI, M., ÖZTÜRK, F., ÇAKIR, A. (2021). Gastroprotective and Antioxidant Effects of the Cinnamon, Cumin, Sumac on Indomethacin Induced Gastric Ulcer in Rats. Eurasian Journal of Food Science and Technology, Cilt: 5 - Sayı: 2, 147–166. https://ajindex.com/articles/756225

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (13)

  1. Aebi H. 1984. Catalase Methods. Enzymol, 105, 121–126. Akgül A. 1997. Baharatlar: Lezzet, koku ve renk dünyası, Gıda Sanayii, 48, 27-34.
  2. Albayrak F., Odabasoglu F., Halici Z., Polat B., Dursun H., Uyanik A., Bayir Y., Koc F., Suleyman H. & Albayrak Y. 2010. The role of erythropoietin in the protection of gastric mucosa from indomethacin-induced gastric injury and its relationship with oxidant and antioxidant parameters in rats, J Pharm Pharmacol, 62, 85–90.
  3. Ames B.N., Gold L.S. & Wille W.C. 1995.
  4. The causes and prevention of cancer, Proc Natl Acad Sci USA, 92, 5258–5265. Aran N. 1988. Baharatın antimikrobiyal etkileri. 20. Diyabet ve Beslenme Günleri, 5. Diyabet Yıllığı: 16-18
  5. Haziran, İstanbul, 383-387.
  6. Atalay F., Halici M., Cadirci E., Aydin-Berktas O., Halici Z. & Cakir A. 2016. N-acetyl cysteine has both gastro-protective and anti-inflammatory effects in experimental rat models: Its gastro-protective effect is related to its in vivo and in vitro antioxidant properties, J Cell Biochem, 117, 308-319.
  7. Baublis A. J., Clydesdale F. M. & Decker E. A. 2000. Antioxidants in Wheat-Based Breakfast Cereals, Cereals Foods World, 45, 71-74. Baytop A. 1983. Farmasötik Botanik. İstanbul:
  8. İstanbul.
  9. Üniversitesi, Eczacılık Fakültesi Dilek Matbaasi Yayınları, 3158. Bradley P.P., Priebat D.A., Christensen R.D. & Rothstein G. 1982. Measurement of cutaneous inflammation: Estimation of neutrophil content with an enzyme marker J Invest Dermatol, 78, 206–20.
  10. Cadirci E., Oral A., Odabasoglu F., Kilic C., Coskun K., Halici Z., Suleyman H., Keles O.N. & Unal B. 2016b. Alpha-lipoic acid as a potential target for the treatment of lung injury caused by cecal ligation and puncture-induced sepsis model in rats, Shock, 33(5), 479–84.
  11. Cadirci E., Altunkaynak B.Z., Halici Z., Odabasoglu F., Uyanik H., Gundogdu C., Suleyman H., Halici M., Albayrak M. & Unal B. 2010. Atorvastatin reduces tissue damage in rat ovaries subjected to torsion and detorsion: biochemical and histopathologic evaluation, N-S Arch Pharmacol, 381(5), 455–466.
  12. Caia Y., Luob Q., Sunc M. & Corkea H. 2004. Antioxidant activity and phenolic compounds of 112 traditional Chinese medicinal plants associated with anticancer Life Sci, 72, pp. 2157–2184.
  13. Chen G., Kamal M., Hannon R. & Warner T.D. 1998. Regulation of cyclo-oxygenase gene expression in rat smooth muscle cells by catalase, Biochem Pharmacol, 55, 1621–1631. Davis P.H. 1967. Flora of Turkey and the East Aegean Islands, Edinburgh:University Press, 2 De la Lastra C.A.