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Journals / Cankaya University Journal of Science and Engineering / 2010 / Cilt: 7 - Sayı: 1

Renal İskemi-Reperfüzyonu Sırasında Sıçan Böbreğinde Oluşan Oksidatif Stres Hasarına Silimarin Etkisi

Hakan ŞENTÜRK
Dürdane KOLANKAYA
Yalçın ŞAHİN
Pages
1–1
Publication Date
2010-02-01
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this study, we investigated the protective effect of silymarin during the experimental renal ischemia reperfusion injury in rats histologically and biochemically.

📌 3 Key Takeaways

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Objective & Hypothesis:Renal ischemia reperfusion injury is the most common causes of acute renal failure.
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Key Findings & Data:Gaertn. (milk thistle) is a plant which belongs to Asteraceae family.
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Conclusion & Impact:In this study, we investigated the protective effect of silymarin during the experimental renal ischemia reperfusion injury in rats histologically and biochemically.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Ischemia-reperfusion · kidney · silymarin

Abstract

Renal ischemia reperfusion injury is the most common causes of acute renal failure. Silybum marianum L. Gaertn. (milk thistle) is a plant which belongs to Asteraceae family. Silymarin is a plant derived flavonoid which is extracted from the seeds of the S. marianum L. In this study, we investigated the protective effect of silymarin during the experimental renal ischemia reperfusion injury in rats histologically and biochemically.

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Cite This Article

ŞENTÜRK, H., KOLANKAYA, D., ŞAHİN, Y. (2010). Renal İskemi-Reperfüzyonu Sırasında Sıçan Böbreğinde Oluşan Oksidatif Stres Hasarına Silimarin Etkisi. Cankaya University Journal of Science and Engineering, Cilt: 7 - Sayı: 1, 1–1. https://ajindex.com/articles/746115

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References (15)

  1. O. Aruoma, H. Kaur, and B. Halliwell, Oxygen free radicals and human diseases, The Journal of the Royal Society for the Promotion of Health 111 (1991), 172–177
  2. N. A. Porter, Chemistry of lipid peroxidation, Methods in Enzymology 105 (1984), 273–282
  3. P. A. Southorn and G. Powis, Free radicals in medicine. I, Chemical nature and biologic reactions, Mayo Clin. Proc. 63 (1988), 381–389
  4. T. Ding, S. Tian, Z. Zhang, D. Gu, Y. Chen, Y. Shi, and Z. Sun, Determination of active component in silymarin by RP-LC and LC/MS, J. Pharmacol. Biomed. Anal. 26 (2001), 155–161
  5. C. Nencini, G. Giorgi, and L. Micheli, Protective effect of silymarin on oxidative stress in rat brain, Phytomedicine 14 (2007), 129–135
  6. H. De Groot and U. Rauen, Tissue injury by reactive oxigen species and the protective effect of flavanoids, Fundam. Clin. Pharmacol. 12 (1998), 249–255
  7. A. Valenzuela, M. Aspillaga, S. Vial, and R. Guerra, Selectivity of silymarin on the increase of the glutathione content in different tissues of the rat, Planta Med. 55 (1989), 420–422
  8. J. Zhao, M. Lahiri-Chatterjee, Y. Sharma, and R. Agarwal, Inhibitory effect of a flavonoid antioxidant silymarin on benzoyl peroxide-induced tumor promotion, oxidative stres and inflammatory responses in SENCAR Mouse skin, Carcinogenesis 21 (2000), 811–816
  9. E. Bosisio, C. Benelli, and O. Pirola, Effect of flavanoligans of Silybum marianum L. on lipid peroxidation in rat liver microsomes and freshly isolated hepatocytes, Pharmacol. Res. 25 (1992), 147–154
  10. V. Kˇren and D. Walterov´a, Silybin and silymarin-new effects and new applications, Biomedical 149 (2005), 29–41
  11. J. Sonnenbichler, F. Sacelera, I. Sonnenbichler, and R. Weyhenmeyer, Stimulatory effects of silibinin and silicristin from the milk thistle Silybum marianum on kidney cells, The Journal of Pharmacology and Experimental Therapeutics 290 (1999), 1375–1383
  12. H. B. Waynforth and P. A. Flecknell, Experimental and surgical technique in the rat, 2 nd ed., Academic Press Limited, London 1994
  13. G. S¸ener, E. S¸ener, O. S¸ehirli, A. V. ¨ O˘g¨un¸c, S¸. C¸ etinel, N. Gedik and A. Sakarcan, Ginkgo ¨ biloba extract ameliorates ischemia-reperf¨usion-induced injury in rats, Pharmacological Research 52 (2005), 216–222
  14. Y. Kaya, E. Aral, T. Co¸skun, N. Erkasap, and A. Var, Increased intraabdominal pressure impairs liver regeneration after partial hepatectomy in rats, Journal of Surgical Research 108 (2002), 250–257
  15. N. Sanz,