SavedAdd your journal

Journals / Current Research in Dental Sciences / 2013 / Supplement 7

Bisphosphonate Related Osteonecrosis Of The Jaws(Bronj) And The Current Treatment Modalities

Bisfosfonatlara Bağlı Olarak Çene Kemiklerinde Gelişen Osteonekroz (Bon) ve Güncel Tedavi Yöntemleri

Yrd. Doç.dr. İsmail Doruk KOÇYİĞİT
Dt. Süleyman KAMAN
Yrd. Doç. Dr. Fethi ATIL
Doç. Dr. Umut TEKİN
Prof. Dr. Hakan H. TÜZ
Pages
1–1
Publication Date
2013-07-01
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Actual prevention methods of the osteonecrosis are also discussed.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Recently bisphosphonates are widely used for treatment of many bone metabolism related disease and cancer treatment.
📊
Key Findings & Data:There are lots of case reports and studies concerned with the jaw bone osteonecrosis which depends on long term use of the bisphosphonates.
💡
Conclusion & Impact:Actual prevention methods of the osteonecrosis are also discussed.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Anahtar Kelimler: Bisfosfonat · kemik · nekroz

Abstract

Recently bisphosphonates are widely used for treatment of many bone metabolism related disease and cancer treatment. There are lots of case reports and studies concerned with the jaw bone osteonecrosis which depends on long term use of the bisphosphonates. However, the role of bisphosphonates in the etiology of osteonecrosis is still unclear. The purpose of this report is giving broadly information about the chemical structures of bisphosphonates, mechanisms of action, radiogaphic findings, complications and current treatment modalities. Actual prevention methods of the osteonecrosis are also discussed.

Özet

Bisfosfonatlar günümüzde kemik metabolizmasıyla ve kanser tedavisi ile ilgili çok sayıda hastalığın tedavisinde yaygın olarak kullanılmaktadır. İlacın uzun süre kullanımına bağlı çene kemiklerinde oluşan osteonekrozla ilişkili bir çok vaka raporu ve çalışma mevcut olmasına rağmen ilacın osteonekrozun etiyolojisinde nasıl bir rol oynadığı hala tam olarak açıklanamamıştır. Bu çalışmada bisfosfonatların kimyasal yapıları, etki mekanizmaları, radyolojik bulguları, kullanımına bağlı ortaya çıkan komplikasyonlar ve osteonekrozun oluşmasını önlemeye yönelik yapılması gerekenler ve güncel tedavi yaklaşımı hakkında bilgi verilecektir.

🔖

Cite This Article

KOÇYİĞİT, Y. D. İ. D., KAMAN, D. S., ATIL, Y. D. D. F., TEKİN, D. D. U., TÜZ, P. D. H. H. (2013). Bisphosphonate Related Osteonecrosis Of The Jaws(Bronj) And The Current Treatment Modalities. Current Research in Dental Sciences, Supplement 7, 1–1. https://ajindex.com/articles/736123

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (8)

  1. Font RF, Garcia ML, Martinez JMO. Osteochemonecrosis of the jaws due to bisphosphonate treatments: Update. Med Oral Patol Oral Cir Bucal 2008;13:318-24. Reid IR. Anti-resorptive therapies for osteoporosis. Seminars in Cell & Developmental Biology. 2008;19:473-8.
  2. Senel FC, Tekin US, Durmus A, Bagis B. Severe Osteomyelitis of the mandible associated with the use of non-nitrogen containing bisphosphaneta (Disodium Clodronate): Report of a case. J Oral Maxillofac Surg 2007;65:562-5.
  3. Franchimont N, Canalis E. Management of glucocorticoid induced osteoporosis in premenopasual women with autoimmune disease. Autoimmunity Reviews 2003;2:224-8. Katz H. Endodontic implications of biphosphonateassociated osteonecrosis of the jaws: A report of three cases. JOE 2005;31:831-4.
  4. Naidu A, Dechow PC, Spears R, Wright JM, Kessler HP, Opperman LA. The effects of bisphosphonates on osteoblasts in vitro. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008;106:5-13.
  5. Reid IR, Bolland MJ, Grey AB. Is bisphosphonate associated osteonecrosis of the jaw caused by soft tissue toxicity? Bone 2007;41:318-20.
  6. Landesberg R, Cozin M, Cremers S, Woo V, Kousteni S, Sinha S, Garrett-Sinha L, Raghavan S. Inhibition of oral mucosal cell wound healing by bisphosphonates. J Oral Maxillofac Surg 2008;66:839-47.
  7. Leite AF, Figueiredo PT, Melo NS, Acevedo AC, Cavalcanti MG, Paula LM, Paula AP, Guerra EN. Bisphosphonate associated osteonecrosis of the jaws. Report of a case and literature review. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;102:14-21. Dental management of patients receiving oral bishosphonate therapy. 2006 Expert panel recommendations of American Dental Association Council on Scientific Affairs. Kamoun-Goldrat A, Ginisty D, Merrer M. Effect of bisphosphonates on tooth eruption in children with osteogenesis imperfecta. Eur J Oral Sci 2008;116: 195Lehrer S, Montazem A, Ramanathan L, PessinMinsley M, Pfail J, Stock RG, Kogan R. Bisphosphonate-induced osteonecrosis of the jaws, bone markers, and a hypothesized candidate gene. J Oral Maxillofac Surg 2009;67:159-61.
  8. Marx RE, Cillo JE, Ulloa JJ. Oral bisphosphonateinduced osteonecrosis: risk factors, prediction of risk using serum CTX testing, prevention, and treatment. J Oral MaxillofacSurg 2007;65:23974 Montebugnoli L, Felicetti L, Gissi BD, Pizzigallo A, Pelliccioni GA, Marchetti C. Biphosphonateassociated osteonecrosis can be controlled by nonsurgical management. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007;104:473-7.