SavedAdd your journal

Journals / Current Research in Dental Sciences / 2015 / Supplement 10

ROLE OF GENES AND INTERACTION BETWEEN GENES AND ENVIROMENT ON CLEFT LIP AND PALATE ETIOLOGY

DUDAK DAMAK YARIĞI ETYOLOJİSİNDE GENLERİN VE GEN-ÇEVRE ETKİLEŞİMİNİN ROLÜ

Gayem EROĞLU BAYRAK
Elçin ESENLİK
Pages
177–189
Publication Date
2015-05-21
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

For the improvement of the prevention strategies and treatment methods of cleft lip and palate, thorough investigation of the fetal and maternal genoms and taking precautions with the planned pregnancy about the possible risks are of great importance

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Cleft lip and/or cleft palate are one of the most common birth defects.
📊
Key Findings & Data:These anomalies are caused by genetic, environmental factors and combination of these factors.
💡
Conclusion & Impact:For the improvement of the prevention strategies and treatment methods of cleft lip and palate, thorough investigation of the fetal and maternal genoms and taking precautions with the planned pregnancy about the possible risks are of great importance
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Dudak damak yarığı · etiyoloji · genler

Abstract

Cleft lip and/or cleft palate are one of the most common birth defects. These anomalies are caused by genetic, environmental factors and combination of these factors. With recent advances in modern molecular biology and methods which are used for the analysis of population genetics, important progress has been made in identifying some of genes associated with cleft lip and palate. Recently multiple genes have been implicated in the etiology of clefting. Additional disturbances in growth factors or their receptors that may be involved in the failure of fusion include fibroblast growth factor, transforming growth factor-p, platelet-derived growth factor, and epidermal growth factor. In last ten years, especially interactions between some genes and enviromental factors were pointed out in cleft lip and palate etiology. For the improvement of the prevention strategies and treatment methods of cleft lip and palate, thorough investigation of the fetal and maternal genoms and taking precautions with the planned pregnancy about the possible risks are of great importance

Özet

Dudak ve /veya damak yarıkları sıklıkla görülen doğumsal anomalilerdendir. Bu anomaliler genetik, çevresel faktörler ve bu faktörlerin kombinasyonu sonucu meydana gelmektedir. Popülasyon genetiğinin analizinde kullanılan modern moleküler biyoloji ve metodlardaki son gelişmelerle birlikte dudak damak yarığı ile ilişkili bazı genlerin aydınlatılmasında ilerleme kaydedilmiştir. Son zamanlarda dudak damak yarığı etiyolojisinde çoklu genler sorumlu tutulmaktadır. İlaveten fibroblast büyüme faktörü, transforming bü- yüme faktörü, platelet kökenli büyüme faktörü ve epidermal büyüme faktörü gibi büyüme faktörleri veya reseptörlerindeki bozukluklar da füzyonda başarısızlığa sebep olan faktörlere dahil edilmiştir. Son on yılda özellikle genler ve çevresel faktörler arasındaki etkile- şimler dudak damak yarığı etiyolojisinde vurgulan- maktadır. Dudak damak yarığı için alınacak önlemlerin ve tedavi metodlarının geliştirilmesi için fetal ve maternal genomların çok iyi araştırılması, planlı hamilelikle beraber olası riskler konusunda önlemlerin alınması büyük önem taşımaktadır.

🔖

Cite This Article

BAYRAK, G. E., ESENLİK, E. (2015). ROLE OF GENES AND INTERACTION BETWEEN GENES AND ENVIROMENT ON CLEFT LIP AND PALATE ETIOLOGY. Current Research in Dental Sciences, Supplement 10, 177–189. https://ajindex.com/articles/736028

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (13)

  1. Bayındır F, Ulu H. Ön bölge diş eksikliği ve yer darlığı olan dudak damak yarıklı bir olguda estetik yaklaşımlar. Atatürk Üniv Diş Hek Fak Derg 2013;23:247-51.
  2. Özdemir H, Aladağ Lİ. Konjenital dudak damak yarıklı bir hastanın sabit ve hassas tutuculu protezlerle rehabilitasyonu. Atatürk Üniv Diş Hek Fak Derg 2013;7:38-43.
  3. Field LL, Ray AK, Marazita ML. Transforming growth factor alpha: a modifying locus for nonsyndromic cleft lip with or without cleft palate. Eur J Hum Genet 1994;2:159-65. Murray JC. Face facts: genes, environment, and clefts. Am J Hum Genet 1995;57:227-32.
  4. Schutte BC, Murray JC. The many faces and factors of orofacial clefts. Hum Mol Genet 1999;8:1853-9.
  5. Prescott NJ, Lees MM, Winter RM. Identification of susceptibility loci for nonsyndromic cleft lip with or without cleft palate in a two stage genome scan of affected sib-pairs. Hum Genet 2000;106:345-50.
  6. Van den Boogaard MJH, Dorland M, Beerner FA. MSX1 mutation is associated with orofacial clefting and tooth agenesis in humans. Nat Genet 2000;24:342-3.
  7. Wyszynski DF, Beaty TH. Review of the role of potential teratogens in te origin of human non- syndromic oral clefts. Teratology 1996;53:309-17.
  8. Prescott NJ, Winter RM, Malcolm S. Non-syndromic cleft lip and palate: complex genetics and environmental 2001;65:505-15. Ann Hum Genet Spritz RA. The genetics and epigenethics of orofacial clefts. Curr Opin Pediatr 2001;13:556-60.
  9. Wilkie AO, Morriss-Kay GM. Genetics of craniofacial development and malformation. Nature Reviews Genetics 2001;2:458-68. Murray JC. Gene/environment causes of cleft lip and/ or palate. Clin Genet 2002;61:248-56.
  10. Stainer P, Moore GE. Genetics of cleft lip and palate: syndromic genes contribute to the incidence of non-syndromic clefts. Hum Mol Genet 2004;1:13. Öner C. Genetik Kavramlar. 6. Baskı. Ankara; Palme Yayıncılık: 2003. p.5-9.
  11. Collins F, Galas D. A new five-year plan for the Genome U.S. 1993;262:43-6.
  12. Project. Science Tuğ A, Hancı H, Balseven A. İnsan genom projesi: Umut mu, Kabus mu? Sted 2002;11:56-7.
  13. Lüleci G, Sakızlı M, Alper Ö. Renkli Genetik Atlası. İstanbul; Nobel Tıp Kitabevi: 2000. p. 46,126,156. Baydar H. Genetik. Isparta; SDÜ Basımevi: 2002. p. 29,148. Lidral AC, Moreno LM, Bullard SA. Genetic factors and orofacial clefting. Semin Orthod 2008;14:103- 14. Dixon MJ, Marazita ML, Beaty TH, Murray JC. Cleft lip and palate: synthesizing genetic and environmental influences. Nat Rev Genet Jamilian A, Nayeri F, Babayan A. Incidence of cleft lip and palate in Te