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Journals / Anatomy / 2020 / Cilt: 14 - Sayı: 1

Enteric nervous system, gut-brain connection and related neurodevelopmental disorders (Review paper)

Ece ALIM
İsmail GÜLEKON
Kerem ATALAR
Meltem BAHCELIOGLU
Journal
Anatomy
Pages
61–67
Publication Date
2020-04-30
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Further researches revealing these relations may provide new approaches for understanding neurodegenerative, psychiatric and behavioral diseases.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The vagus nerve is the primary neural medium which enables gastrointestinal tract and brain communication.
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Key Findings & Data:Hippocampus, a region of the brain commonly linked to memory function, is activated by vagus nerve-mediated gastrointestinal signals.
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Conclusion & Impact:Further researches revealing these relations may provide new approaches for understanding neurodegenerative, psychiatric and behavioral diseases.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:enteric nervous system · gut-brain connection · neurodegenerative disease

Abstract

The vagus nerve is the primary neural medium which enables gastrointestinal tract and brain communication. Hippocampus, a region of the brain commonly linked to memory function, is activated by vagus nerve-mediated gastrointestinal signals. Vagal afferent information is received by the medial solitary nucleus and is then transmitted via ascending neural pathways to different regions of the forebrain and hindbrain. Explanation of the exact mechanisms of microbiota and amygdala communication requires further research. By linking microbial activities to progressive structural and functional events in the brain in mice models and in humans, we can suggest that intestinal microbiota is an important contributor to neurodevelopment and neurodegeneration. Further researches revealing these relations may provide new approaches for understanding neurodegenerative, psychiatric and behavioral diseases.

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Cite This Article

ALIM, E., GÜLEKON, İ., ATALAR, K., BAHCELIOGLU, M. (2020). Enteric nervous system, gut-brain connection and related neurodevelopmental disorders (Review paper). Anatomy, Cilt: 14 - Sayı: 1, 61–67. https://ajindex.com/articles/712374

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References (12)

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