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Journals / Anatomy / 2021 / Cilt: 15 - Sayı: 3

Quantitative evaluation of the cerebellum in patients with depression and healthy adults by VolBrain method

Güzin ÖZMEN
Duygu AKIN SAYGIN
İsmihan İlknur UYSAL
Seral ÖZŞEN
Yahya PAKSOY
Özkan GÜLER
Journal
Anatomy
Pages
207–215
Publication Date
2021-12-31
DOI
—
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

The cortical thickness of lobule V (right-total), lobule VIIIB (right), and lobule IX (right) was smaller in the depressed group, independent of sex (p

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: Besides the well-known sensorimotor control function, the cerebellum is also associated with cognitive functions and mood via the cerebral-cerebellar circuit.
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Key Findings & Data:Methods: Brain magnetic resonance (MR) images of 40 adults (age: 18–50 years), including 20 untreated depression patients and 20 healthy controls were analysed prospectively.
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Conclusion & Impact:The cortical thickness of lobule V (right-total), lobule VIIIB (right), and lobule IX (right) was smaller in the depressed group, independent of sex (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:cerebellum · depression · neuroanatomy

Abstract

Objectives: Besides the well-known sensorimotor control function, the cerebellum is also associated with cognitive functions and mood via the cerebral-cerebellar circuit. This study aimed to investigate possible cerebellar morphometric changes in untreated patients with depression. Methods: Brain magnetic resonance (MR) images of 40 adults (age: 18–50 years), including 20 untreated depression patients and 20 healthy controls were analysed prospectively. Intracranial cavity and total cerebellar volumes were measured by using VolBrain. The cerebellum segmentation was performed with CERES to obtain the total gray matter volumes and cortical thickness of the lobules. Results: Total cerebellar volume was 141.27±13.12 cm3 in the depressed group and 142.63±8.01 cm3 in the control group (p>0.05). The difference between males and females in the depressed group was not statistically significant (p>0.05). Total cerebellar volume was approximately 11% of total intracranial volume in both groups. The cortical thickness of lobule V (right-total), lobule VIIIB (right), and lobule IX (right) was smaller in the depressed group, independent of sex (p

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Cite This Article

ÖZMEN, G., SAYGIN, D. A., UYSAL, İ. İ., ÖZŞEN, S., PAKSOY, Y., GÜLER, Ö. (2021). Quantitative evaluation of the cerebellum in patients with depression and healthy adults by VolBrain method. Anatomy, Cilt: 15 - Sayı: 3, 207–215. https://ajindex.com/articles/712353

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References (11)

  1. Shakiba A. The role of the cerebellum in neurobiology of psychiatric disorders. Neurol Clin 2014;32:1105–15. Standring S. Gray’s anatomy: the anatomical basis of clinical practice. 41th ed. London: Churchill Livingstone Elsevier; 2016. p. 331–50.
  2. Baumann O, Mattingley JB. Functional topography of primary emotion processing in the human cerebellum. Neuroimage 2012;61: 805–11.
  3. Kansal K, Yang Z, Fishman AM, Sair HI, Ying SH, Jedynak BM, Prince JL, Onyike CU. Structural cerebellar correlates of cognitive and motor dysfunctions in cerebellar degeneration. Brain 2017;140: 707–20.
  4. Stoodley CJ, Schmahmann JD. Functional topography of the human cerebellum. Handb Clin Neurol 2018;154:59–70.
  5. Depping MS, Wolf ND, Vasic N, Sambataro F, Hirjak D, Thomann PA, Wolf RC. Abnormal cerebellar volume in acute and remitted major depression. Prog Neuropsychopharmacol Biol Psychiatry 2016;71:97–102. Schmahmann JD. The cerebellum and cognition. Neurosci Lett 2019;688:62–75. American Psychiatric Association. Diagnostic and Statistical manual of mental disorders. 4th ed. Washington DC: American Psychiatric Press;2000. p. 429–85. Lai CH. Gray matter volume in major depressive disorder: a meta-analysis of voxel-based morphometry studies. Psychiatry Res 2013; 211:37–46.
  6. Peng W, Chen Z, Yin L, Jia Z, Gong Q. Essential brain structural alterations in major depressive disorder: a voxel-wise meta-analysis on first episode, medication-naive patients. J Affect Disord 2016;15: 114–23.
  7. Escalona PR, Early B, McDonald WM, Doraiswamy PM, Shah SA, Husain MM, Boyko OB, Figiel GS, Ellinwood EH, Nemeroff CB, Krishnan KRR. Reduction of cerebellar volume in major depression: a controlled MRI study. Depression 1993;1:156–8.
  8. Depping MS, Nolte HM, Hirjak D, Palm E, Hofer S, Stieltjes B, Maier-Hein K, Sambataro F, Wolf RC, Thomann PA. Cerebellar volume change in response to electroconvulsive therapy in patients with major depression. Prog Neuropsychopharmacol Biol Psychiatry 2017;73:31–5.
  9. Bogoian HR, King TZ, Turner JA, Semmel ES, Dotson VM. Linking depressive symptom dimensions to cerebellar subregion volumes in later life. Transl Psychiatry 2020;10:201. Manjón JV, Coupé P. VolBrain: an online MRI brain volumetry system. Front Neuroinform 2016;10:1–14.
  10. Romero JE, Coupé P, Giraud R, Ta VT, Fonov V, Park MTM, Mallar Chakravarty M, Voineskos AN, Manjón JV. CERES: a new cerebellum lobule segmentation method. Neuroimage 2017;147: 916–24.
  11. Yılmaz S, Tokpinar A, Acer N, Degirmencioglu L, Ates S, Bastepe Gray S. E