Hyperbaric Oxygen Experience on Treatment of the Bisphosphonate-Related Osteonecrosis of Jaw (Bronj): Case Report of a Metastatic Breast Cancer Patient

Özet

SUMMARY: The Bisphosphonate-Related Osteonecrosis of the Jaw (BRONJ) is an exposed necrotic alveolar bone associated with intravenous (IV) administration of Bisphosphonate (BP) therapy of multiple myeloma and bone metastases without previous radiation therapy (RT) to the maxillo-facial region (1,2,3). Hyperbaric Oxygen (HBO) treatment is one of the option which used on treatment of BRONJ, via increasing stem cell mobilisation, decreasing oedema, inflammation, and accelerating to wound healing (4,5). In this report, the case with metastatic breast cancer who has BRONJ was presented, and treatment of BRONJ with HBO was discussed.ÖZET: Bifosfonata bağlı çene osteonekrozisi (BBCO) kemik metastazı veya multipl myeloma’da kullanılan intravenöz bifosfonat ile ilişkili, daha önce radyoterapi uygulanmamış maksillofasiyal bölge alveoler kemiklerinin nekrozudur (1,2,3). Hiperbarik oksijen (HBO) kök hücre mobilizasyonu arttırma, ödem, inflamasyonu azaltma ve hasar iyileşmesini hızlandıraması yoluyla, BBCO tedavisinde kullanılan seçeneklerden biridir (4,5). Bu raporda metastatik meme kanserli bir BBCO olgusu sunulacak ve BBCO tedavisinde HBO tartışılacaktır.