Journals / Online Türk Sağlık Bilimleri Dergisi / 2018 / Cilt: 3 - Sayı: 1

Cytokines

Sitokinler

Pages
36–45
Publication Date
2018-03-31
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

All those types of cytokines are produced by a broad range of cells, including immune cells like macrophages, B lymphocytes, T lymphocytes and mast cells, as well as endothelial cells, fibroblasts, and various stromal cells; a given cytokine may be produced by more than one type of cell.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Cytokines are a broad and loose category of small proteins (~5–20 kDa) that are important in cell signaling.
📊
Key Findings & Data:They are released by cells and affect the behavior of other cells, and sometimes the releasing cell itself.
💡
Conclusion & Impact:All those types of cytokines are produced by a broad range of cells, including immune cells like macrophages, B lymphocytes, T lymphocytes and mast cells, as well as endothelial cells, fibroblasts, and various stromal cells; a given cytokine may be produced by more than one type of cell.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:stokinler · kemokinler · interlökinler

Abstract

Cytokines are a broad and loose category of small proteins (~5–20 kDa) that are important in cell signaling. They are released by cells and affect the behavior of other cells, and sometimes the releasing cell itself. There are many types of Cytokines, including chemokines, interferons, interleukins, lymphokines, tumour necrosis factor but generally not hormones or growth factors (despite some terminologic overlap). All those types of cytokines are produced by a broad range of cells, including immune cells like macrophages, B lymphocytes, T lymphocytes and mast cells, as well as endothelial cells, fibroblasts, and various stromal cells; a given cytokine may be produced by more than one type of cell.

Özet

Sitokinler, hücre işaretlemesinde önem taşıyan geniş ve gevşek küçük protein kategorileri (~ 5-20 kDa)’dir. Hücreler tarafından serbest bırakılır ve diğer hücrelerin davranışını etkiler ve bazen hücrenin kendisini serbest bırakır. Kemokinler, interferonlar, interlökinler, lenfokinler, tümör nekroz faktörü, ancak genellikle hormonlar veya büyüme faktörleri (bazı terminolojik örtüşmelere rağmen) olmayan pek çok Sitokin türü vardır. Tüm bu tip sitokinler, makrofajlar, B lenfositleri, T lenfositleri ve mast hücreleri gibi bağışıklık hücrelerinin yanı sıra endotel hücreleri, fibroblastlar ve çeşitli stromal hücreler de dahil olmak üzere geniş bir hücre yelpazesi tarafından üretilir; Verilen bir sitokin birden fazla hücre türü tarafından üretilebilir.

🔖

Cite This Article

AKDOĞAN, M., YÖNTEM, M. (2018). Cytokines. Online Türk Sağlık Bilimleri Dergisi, Cilt: 3 - Sayı: 1, 36–45. https://ajindex.com/articles/694533

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (13)

  1. Nororiha IL, Niemir Z. Stein H, Waldher R. Cytokines and growth factors in renal disease: Nephrol Dial Transplant 1995, 10: 775-786
  2. Abul K. Abbas, Andrew H. Lichtman, Jordan S. Pober. Cellular and Molecular Immunology First Edition. HBJ International Edition W.B. Saunders 1991. 3.
  3. Judith A. Owen, Jenni Punt, Sharon A. Stranford. Kuby Immunology, 7th Edition. Macmillan, USA, 2007. 5.
  4. Dinarello C. Biologic basis for interleukin-1 in disease. Blood, 1996; 87: 2095-2147
  5. Yi-June L, Cheing Meii L, Man-YingW, Lein-Tuan H, Weikuei C. Interleukin-1 secreting cells in inflamed gingival tissue of adult periodontitis patients, Cytokine, 1999; 11: 626-633
  6. Meagher C, Sharif S, Hussain S, Cameron M, Arreaza G, Delovitch T. Cytokines and chemokines in the pathogenesis of murine type 1 diabetes In: Santamaria P, ed. Cytokines and Chemokines in Autoimmune Disease Austin: RG Landes Co.,2001
  7. Willenborg D, Staykova M. Cytokines in the pathogenesis and therapy of autoimmune encephalomyelitis and multiplesclerosis In: Santamaria P, ed. Cytokines and Chemokines in Autoimmune Disease Austin: RG Landes Co.,2001
  8. Sergei I. Grivennikov, Florian R. Greten, and Michael Karin. Immunity, Inflammation, and Cancer. Cell. 2010 Mar 19; 140(6): 883–899
  9. Jun-Ming Zhang, MSc, MD1 and Jianxiong An, MSc, MD. Cytokines, Inflammation and Pain. Int Anesthesiol Clin Int Anesthesiol Clin. 2009; 45(2): 27–37
  10. Reem Karmali, Laura A. Paganessi, Robin R. Frank, Sucheta Jagan, Melissa L. Larson, Parameswaran Venugopal, Stephanie A. Gregory, and Kent W. Christopherson. Aggressive disease defined by cytogenetics is associated with cytokine dysregulation in CLL/SLL patients. J Leukoc Biol. 2013; 93(1): 161–170
  11. Nachbaur DM, Herold M, Maneschg A, Huber H. Serum levels of interleukin-6 in multiple myeloma and other hematological disorders: correlation with disease activity and other prognostic parameters. Ann Hematol. 1991 Feb-Mar;62(2-3):54-8
  12. Palladino C, Bruno B, and Boccadoro M. Discovering the Meaning of Monoclonal Gammopathy of Undetermined Significance: Current Knowledge, Future Challenges. Transl Med UniSa. 2014; 8: 12–18
  13. Razelle Kurzrock,2 John Redman, Fernando Cabanillas, Donnah Jones, Jeanne Rothberg, and Moshe Talpaz. Serum Interleukin 6 Levels Are Elevated in Lymphoma Patients and Correlate with Survival i