Association Between Depression and Serum Cortisol Levels Patients with Fibromiyalgia

Serumcortisol average of individuals in patient groupand control group was found as 10.10 ± 4.08цg/dL and 11.78 ± 3.6 цg/dL.Conclusion: In this study, serum cortisol levelsof fibromyalgia patients was significantlylower than levels of healthy control patients.However, there was no significant associationbetween the levels of cortisol and depression.This study show that necessity to psychiatricevaluation in treatment of patients with FM.

📌 3 Key Takeaways

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Objective & Hypothesis:Purpose: The fundamental objective of thisstudy is to determine the depression levels andto review its relations with serum cortisollevels in cases presenting with fibromyalgia(FM).Materials and Methods: Seventy one patientsparticipated in this study who referred tophysiotherapy department, and approved toparticipate in this study, and they werediagnosed with FM by physiotherapistsaccording to American RheumatologyAssociation and they were referred topsychiatry department, afterwards.

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Key Findings & Data:The control group was consistedwith 39 healthy individuals.

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Conclusion & Impact:Serumcortisol average of individuals in patient groupand control group was found as 10.10 ± 4.08цg/dL and 11.78 ± 3.6 цg/dL.Conclusion: In this study, serum cortisol levelsof fibromyalgia patients was significantlylower than levels of healthy control patients.However, there was no significant associationbetween the levels of cortisol and depression.This study show that necessity to psychiatricevaluation in treatment of patients with FM.

🔬Design:Review & Systematic Survey

📍Scope:Comprehensive Sample

⚙️Variables:Depresyon · Fibromiyalji · Kortizol

Abstract

Purpose: The fundamental objective of thisstudy is to determine the depression levels andto review its relations with serum cortisollevels in cases presenting with fibromyalgia(FM).Materials and Methods: Seventy one patientsparticipated in this study who referred tophysiotherapy department, and approved toparticipate in this study, and they werediagnosed with FM by physiotherapistsaccording to American RheumatologyAssociation and they were referred topsychiatry department, afterwards. Therelevant data were obtained by filling the testforms such as socio-demographic dataacquisition form and Beck DepressionInventory. The control group was consistedwith 39 healthy individuals. To determine thelevels of the cortisol, the blood samples weretaken between 08.00 am-09.00 am from thepatients and the control group that match withthe study criteria.Results: In this study, mild depression wasdetected in 63,2% of the participants. Serumcortisol average of individuals in patient groupand control group was found as 10.10 ± 4.08цg/dL and 11.78 ± 3.6 цg/dL.Conclusion: In this study, serum cortisol levelsof fibromyalgia patients was significantlylower than levels of healthy control patients.However, there was no significant associationbetween the levels of cortisol and depression.This study show that necessity to psychiatricevaluation in treatment of patients with FM.

Özet

Amaç: Bu çalışmanın amacı fibromiyalji (FM) tanısı konulmuş hastalarda depresyon ile serum kortizol düzeyi arasındaki ilişkinin araştırılmasıdır.Gereç ve Yöntem: Çalışmaya; fizik Tedavi polikliniğine başvuran, çalışmayı kabul eden, Amerikan Romatoloji Birliği (ACR) kriterlerine göre Fizik tedavi uzmanları tarafından FM tanısı konulduktan sonra psikiyatri polikliniğinde değerlendirilmeye alınan toplam 72 hasta alınmıştır. Sosyodemografik veri toplama formu ve Beck Depresyon Ölçeği içeren test formları doldurularak veriler elde edildi. Kontrol grubu olarak 39 sağlıklı birey alındı. Kortizol düzeylerinin saptanması için, çalışma ölçütlerine uyan hasta ve kontrol grubundan kan örnekleri sabah 08.00-09.00 saatleri arasında alındı.Bulgular: Çalışmaya katılanların %33.2’ sinde hafif düzeyde depresyon tespit edilmiştir. Hasta grubundaki bireylerin serum kortizol ortalaması 10.10 ± 4.08 цg/dL, kontrol grubundaki bireylerin kortizol ortalaması 11.78 ± 3.6 цg/dL bulunmuştur.Sonuç: Çalışmamızda fibromiyalji hastalarının serum kortizol düzeylerinin sağlıklı kontrollerden anlamlı düzeyde daha düşük olduğu saptanmıştır. Depresyon ile serum kortizol düzeyi arasında korelasyon bulunmamıştır. Bu çalışma FM hastalarının tedavisinde psikiyatrik değerlendirmenin gerekliliğini göstermiştir.

Keywords

Depresyon Fibromiyalji Kortizol Cortisol Depression Fibromyalgia Cortisol

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Cite This Article

SEMİZ, E., HİZMETLİ, S., SEMİZ, M., KARADAĞ, A., ALIM, B., ADALI, M., TUNÇAY, M., ÇÖPOĞLU, Ü. (2015). Association Between Depression and Serum Cortisol Levels Patients with Fibromiyalgia. Mustafa Kemal Üniversitesi Tıp Dergisi, Cilt: 5 - Sayı: 19, 8–18. https://ajindex.com/articles/692926

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