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Journals / KONURALP TIP DERGİSİ / 2022 / Cilt: 14 - Sayı: 3

The Effect of Different Doses of Amantadine on Lung Tissue In Hepatıc Ischemia Reperfusion Injury in Rats

Sıçanlarda Hepatik İskemi Reperfüzyon Hasarında Farklı Dozlarda Amantadin'in Akciğer Dokusu Üzerine Etkisi

Fatih ŞAHİN
Mustafa ORHAN
Ayça TAŞ TUNA
Onur PALABIYIK
Nevcihan ŞAHUTOĞLU BAL
Sezen Irmak GÖZÜKARA
Özcan BUDAK
Hüseyin ÇAKIROĞLU
Pages
520–525
Publication Date
2022-10-20
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Result: A significant difference was found between the groups in terms of MDA, SOD, CAT levels (respectively; p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: N-Methyl D-Aspartate (NMDA) receptor blockers have been shown to have protective effects against ischemia/reperfusion (I/R) injury in various tissues.
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Key Findings & Data:The aim of this study was to investigate the effects of 90 ve 135 mg/kg doses of amantadine on lung in hepatic I/R injury.
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Conclusion & Impact:Result: A significant difference was found between the groups in terms of MDA, SOD, CAT levels (respectively; p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Amantadin · İskemi Reperfüzyon Hasarı · Akciğer Hasarı

Abstract

Objective: N-Methyl D-Aspartate (NMDA) receptor blockers have been shown to have protective effects against ischemia/reperfusion (I/R) injury in various tissues. The aim of this study was to investigate the effects of 90 ve 135 mg/kg doses of amantadine on lung in hepatic I/R injury. Method: The rats were randomly divided into six groups: Group Sham, Group I/R, Group Amantadine-90, Group Amantadine-135, Group I/R-90 and Group I/R-135. In I/R, an atraumatic vascular clamp was applied to the structures in the left portal triad for 45 minutes and reperfusion period was 2 hours after ischemia. Malondialdehyde (MDA), superoxide dismutase (SOD) and catalase (CAT) enzyme levels were performed the lung tissue and tissues were examined histopathologically. Result: A significant difference was found between the groups in terms of MDA, SOD, CAT levels (respectively; p

Özet

Amaç: N-Metil D-Aspartat (NMDA) reseptör blokerlerinin çeşitli dokularda iskemi/reperfüzyon (I/R) hasarına karşı koruyucu etkileri olduğu gösterilmiştir. Bu çalışmanın amacı, hepatik I/R hasarında 90 ve 135 mg/kg dozlarındaki amantadinin akciğer üzerindeki etkilerini araştırmaktır. Gereç ve Yöntem: Sıçanlar her rastgele altı gruba ayrıldı: Grup Sham, Grup I/R, Grup Amantadin-90, Grup Amantadin-135, Grup I/R-90 ve Grup I/R-135. I/R'de sol portal triaddaki yapılara 45 dakika süre ile atravmatik vasküler klemp uygulandı ve iskemi sonrası 2 saat reperfüzyon uygulandı. Akciğer dokusunda malondialdehit (MDA), süperoksit dismutaz (SOD) ve katalaz (CAT) enzim düzeyleri ölçüldü ve dokular histopatolojik olarak incelendi. Bulgular: MDA, SOD, CAT düzeyleri açısından gruplar arasında anlamlı fark bulundu (sırasıyla; p

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Cite This Article

ŞAHİN, F., ORHAN, M., TUNA, A. T., PALABIYIK, O., BAL, N. Ş., GÖZÜKARA, S. I., BUDAK, Ö., ÇAKIROĞLU, H. (2022). The Effect of Different Doses of Amantadine on Lung Tissue In Hepatıc Ischemia Reperfusion Injury in Rats. KONURALP TIP DERGİSİ, Cilt: 14 - Sayı: 3, 520–525. https://ajindex.com/articles/686629

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