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Journals / Journal of Experimental and Clinical Medicine / 2009 / Cilt: 26 - Sayı: 3

Effects Of Pınealectomy On Morphologıcal Features Of Blood Vessel In Chıcken: An Electron Mıcroscopıc And Stereologıcal Study

Mehmet TURGUT
Süleyman KAPLAN
Zeynep ÜNAL
Zuhal ALTUNKAYNAK
Deniz ÜNAL
Bünyamin ŞAHİN
Mehmet BOZKURT
Mine YURTSEVEN
Pages
112–118
Publication Date
2010-12-30
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The present results indicate that pinealectomy had a vasodilator effect on the sciatic artery.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Although the effects of melatonin on vascular smooth muscle and vascular reactivity are described in last decade, the effects of melatonin on vascular tissues are still vague.
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Key Findings & Data:Fifteen chicks were divided into three groups, namely unoperated control, sham-operated and pinealectomized chicks.
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Conclusion & Impact:The present results indicate that pinealectomy had a vasodilator effect on the sciatic artery.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Artery · Chicken · Electron microscopy

Abstract

Although the effects of melatonin on vascular smooth muscle and vascular reactivity are described in last decade, the effects of melatonin on vascular tissues are still vague. The current study investigated the effects of pinealectomy on the blood vessel wall in the chicken. Fifteen chicks were divided into three groups, namely unoperated control, sham-operated and pinealectomized chicks. At the end of the experiment, a quantitative structural analysis of 15 sciatic artery samples from these groups was investigated. Effects of pinealectomy were quantified using volume fraction approach of stereological method. In this study, total cross-sectional area of the artery in pinealectomy group was significantly higher than those in unoperated control and sham-operated animals (p < 0.05). However, surgical pinealectomy procedure resulted in a significantly decreased thickness of the tunica adventitia of the vessel wall, in contrast to those of tunica media (p < 0.01). The present results indicate that pinealectomy had a vasodilator effect on the sciatic artery. In the light of current study, the structural changes in the vessel demonstrated by quantitative morphometric methods have been interpreted as a reflection of the role of melatonin on vessel wall and vascular reactivity, but this suggestion need to be validated in the human setting.

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Cite This Article

TURGUT, M., KAPLAN, S., ÜNAL, Z., ALTUNKAYNAK, Z., ÜNAL, D., ŞAHİN, B., BOZKURT, M., YURTSEVEN, M. (2010). Effects Of Pınealectomy On Morphologıcal Features Of Blood Vessel In Chıcken: An Electron Mıcroscopıc And Stereologıcal Study. Journal of Experimental and Clinical Medicine, Cilt: 26 - Sayı: 3, 112–118. https://ajindex.com/articles/679131

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