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Journals / Journal of Experimental and Clinical Medicine / 2021 / Cilt: 38 - Sayı: 4

Investigation of in vitro activity of colistin and tygecyclin against Stenotrophomonas maltophilia isolates

Yeliz TANRIVERDİ ÇAYCI
İlknur BIYIK
Gonca YILMAZ
Kemal BİLGİN
Asuman BIRINCI
Pages
529–532
Publication Date
2021-10-09
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

And colistin resistance was determined as 86.9% according to both guidelines.

📌 3 Key Takeaways

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Objective & Hypothesis:Stenotrophomonas maltophilia has emerged as an important opportunistic pathogen, causing infections whose management is often problematic due to its inherent resistance to many antibiotics.
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Key Findings & Data:A total of 122 S. maltophilia isolates were tested.
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Conclusion & Impact:And colistin resistance was determined as 86.9% according to both guidelines.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Stenotrophomonas maltophilia · colistin · tygecycline

Abstract

Stenotrophomonas maltophilia has emerged as an important opportunistic pathogen, causing infections whose management is often problematic due to its inherent resistance to many antibiotics. In this study, we aimed to investigate the antimicrobial susceptiblity of colistin and tygecyclin as an alternative treatment options for S. maltophilia infections. A total of 122 S. maltophilia isolates were tested. Minimum inhibitory concentration (MIC) values of colistin and tygecycline were determined by broth microdilution method. Susceptibility of TMP/SMX and levofloxacin (LVX) were determined by disc diffusion method and MIC value of ceftazidime (CAZ) was determined by using E-test. Out of 122 S. maltophilia isolates, 5 (4%) of them were resistant to TMP-SXM. MIC range was 0.125- >512 μg/ml and MIC50 64 μg/ml, MIC90 512 μg/ml for colistin. MIC range for tygecyclin was detected as 0.5- >8, MIC50 2 μg/ml and MIC90 8 μg/ml. Tygecyclin resistance was detected as 66.4% according to the EUCAST guideline and 13.1% according to the USA-FDA breakpoints. And colistin resistance was determined as 86.9% according to both guidelines.

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Cite This Article

ÇAYCI, Y. T., BIYIK, İ., YILMAZ, G., BİLGİN, K., BIRINCI, A. (2021). Investigation of in vitro activity of colistin and tygecyclin against Stenotrophomonas maltophilia isolates. Journal of Experimental and Clinical Medicine, Cilt: 38 - Sayı: 4, 529–532. https://ajindex.com/articles/677855

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References (8)

  1. Denton M, Kerr KG. Microbiological and Clinical Aspects of Infection Associated with Stenotrophomonas maltophilia. Clın Mıcrob Rev. 1998;11(1): 57–80
  2. Zhang L, Li XZ, Poole K. Multiple antibiotic resistance in Stenotrophomonas maltophilia: involvement of a multidrug efflux system. Antimicrob Agents Chemother. 2000; 44:287–93. 3-Valdezate S, Vindel A, Loza E, Baquero F, Canto´n R. Antimicrobial susceptibilities of unique Stenotrophomonas maltophilia clinical strains. Antimicrob Agents Chemother. 2001;45: 1581–4. 4-Falagas ME, Kastoris AC, Vouloumanou EK, Rafailidis PI, Kapaskelis AM, Dimopoulos G. Attributable mortality of Stenotrophomonas maltophilia infections: a systematic review of the literature. Future Microbiology. 2009; 4:1103-9. 5-Alonso A, Martı´nez JL. Multiple antibiotic resistance in Stenotrophomonas maltophilia. Antimicrob Agents Chemother. 1997; 41:1140–2. 6-Yamazaki E, Ishii J, Sato K, Nakae T. The barrier function of the outer membrane of Pseudomonas maltophilia in the diffusion of saccharides and beta-lactam antibiotics. FEMS Microbiol Lett. 1989; 51:85–8
  3. Nicodemo AC, Paez JI. Antimicrobial therapy for Stenotrophomonas maltophilia infections. Eur J Clin Microbiol Infect Dis. 2007; 26: 229- 37
  4. Gales AC, Jones RN, Forward KR, Linares J, Sader HS, Verhoef J. Emerging importance of multidrug-resistant Acinetobacter species and Stenotrophomonas maltophilia as pathogens in seriously ill patients: geographic patterns, epidemiological features, and trends in the SENTRY Antimicrobial Surveillance Program (1997-1999). Clin Infect Dis. 2001; 32 Suppl 2:S104-S113
  5. Petersen PJ, Jacobus NV, Weiss WJ, Sum PE, Testa RT. In vitro and in vivo antibacterial activities of a novel glycylcycline, the 9-t10 butylglycylamido derivative of minocycline (GAR-936). 174 Antimicrob Agents Chemother. 1999; 43:738-44
  6. Li J, Nationa RL, Milneb RW, Turnidgec JD, Coulthard K. Evaluation of colistin as an agent against multi-resistant Gram-negative bacteria. International Journal of Antimicrobial Agents. 2005; 25: 11–25
  7. Gales AC, Reis AO, Jones RN. Contemporary assessment of antimicrobial susceptibility testing methods for polymyxin B and colistin: review of available interpretative criteria and quality control guidelines. J Clin Microbiol. 2001; 39: 183–90
  8. Hogardt M, Schmoldt S, Gotzfried M, Adler K, Heesemann J. Pitfalls of polymyxin antimicrobial susceptibility testing of Pseudomonas aeruginosa isolated from cystic fibrosis patients. J Antim