Journals / Journal of Experimental and Clinical Medicine / 2021 / Cilt: 38 - Sayı: 4

Does Recurrent Pregnancy Loss Have an Inflammatory Background?

Pages
420–424
Publication Date
2021-10-09
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

We think that further prospective randomized controlled studies are required regarding these parameters.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Although several pathophysiological mechanisms is defined in etiology recurrent pregnancy loss, still causes of half of the cases haven’t revealed yet.
📊
Key Findings & Data:Methods: We included our study 90 pregnants having recurrent miscarriage history and 101 pregnants without this, totally 191 patients.
💡
Conclusion & Impact:We think that further prospective randomized controlled studies are required regarding these parameters.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Recurrent Pregnancy Loss · White blood cell count · C-Reactive protein

Abstract

Objective: Although several pathophysiological mechanisms is defined in etiology recurrent pregnancy loss, still causes of half of the cases haven’t revealed yet. It is reported that inflammatory processes take place in the etiology of the disease. In our study, we aimed to reveal the relationship between recurrent pregnancy loss with white blood cell count (WBC), C-reactive protein (CRP) and ferritin levels. Methods: We included our study 90 pregnants having recurrent miscarriage history and 101 pregnants without this, totally 191 patients. Maternal and gestational age, height, weight, body mass index (BMI), gravidity, parity, abortion and living children count and WBC, CRP and ferritin levels of these pregnants were evaluated retrospectively. The suitability of quantitative data for normal distribution was tested by Kolmogorov-Smirnov, Shapiro-Wilk test and graphical evaluations. Student's t-test was used for comparing two groups of normally distributed quantitative data, and Mann Whitney U test was used for two-group comparisons of non-normally distributed data Result: According to outcomes, while the age (p= 0.01; p0.05). While WBC levels of the study group was found to be lower (p=0.045, p 0.05) Conclusion: In our study, WBC, CRP and ferritin parameters did not indicate the inflammatory background in recurrent pregnancy loss. We think that further prospective randomized controlled studies are required regarding these parameters.

🔖

Cite This Article

GÜVEY, H., ÇELİK, S., ÇALIŞKAN, C. S., YAŞAR, B., YAZICIOĞLU, B., TÜRE, E., ULUBAŞOĞLU, H. (2021). Does Recurrent Pregnancy Loss Have an Inflammatory Background?. Journal of Experimental and Clinical Medicine, Cilt: 38 - Sayı: 4, 420–424. https://ajindex.com/articles/677815

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (14)

  1. Ahmed,S.K., Mahmood, N., Almawi, W.Y, 2015. C-reactive protein gene variants associated with recurrent pregnancy loss independent of CRP serum levels: A case-control study. Gene [Internet]. 569:136–140.
  2. Amsalem, H., Kwan, M., Hazan, A., Jones, R.L., Whittle, W., John, C.P., Croy, B.A., Lye, S.T., Caroline E., 2020. Identification of a novel neutrophil population: proangiogenic granulocytes in second-trimester human decidua. J Immulugy. 193: 3070–3079.
  3. Bas, F.Y. and Tola, E.N., 2018. The role of complete blood inflammation markers in the prediction of spontaneous abortion. J Med Sci. 34: 1381–1385.
  4. Best, L.G., Saxena, R., Anderson, C.M., Barnes, M.R., Hakonarson, H., Falcon, G., Martin, C., Castillo, B.A., Karumanchi, A., Keplin, K., Pearson, N., Lamb, F., Bercier, S., Keating, B.J., 2013. two variants of the C-reactive protein gene are associated with risk of pre-eclampsia in an American Indian population. PLoS One.8: e71231 1-10.
  5. Carrington, B., Sacks, G., Regan, L., 2005. Recurrent miscarriage: Pathophysiology and outcome. Curr Opin Obstet Gynecol. 17: 591–597.
  6. Challis, J.R., Lockwood, C.J, Myatt, L., Norman, J.E., Iii, J.F.S., Petraglia, F., 2009. Inflammation and pregnancy. reproductive sciences. 16: 206–215.
  7. Chaouat, G., Bataille, N.L., Dubanchet, S., Zorbas, S., Sandra, O., Martal, J., 2004. Th1 / Th2 paradigm in pregnancy: Paradigm lost ? Int Arch Allergy Immunol. 134: 93–119.
  8. Cohen, Y,, Ascher-landsberg, J., Cohen, A., Lessing, J.B., Grisaru, D., 2014. The role of C-reactive protein measurement as a diagnostic aid in early pregnancy. Eur J Obstet Gynecol [Internet]. 176: 64–67.
  9. Daglar, H.K., Kirbas, A., Kaya, B., 2016. The value of complete blood count parameters in predicting preterm delivery. Eur Rewiev Med Pharmacol Sci. 20:801–805.
  10. Ghaffari, M.A., Sede, S.A., Rashtchizadeh, N., Mohammadzadeh, G., 2014. Association of CRP gene polymorphism with CRP levels and coronary artery disease in type 2 diabetes in Ahvaz, southwest of Iran. Biolmpacts [Internet]. 4: 133–139.
  11. Guo, Y., Zhang, N., Zhang, D., Ren, Q., Ganz, T., Nemeth, E., 2019. Iron homeostasis in pregnancy and spontaneous abortion. Am J Hematol. 94:184–188.
  12. Kell, D.B. and Pretorius, E., 20014. Serum ferritin is an important inflammatory disease marker, as it is mainly a leakage product from damaged cells. Metallomics. 6: 748–773.
  13. Kuroda, K., 2019. Impaired endometrial function and unexplained recurrent pregnancy loss. Hypertension Res Pregnancy. 7: 16–21.
  14. Laird, S.M., Tuckerman, E.M., Cor