SavedAdd your journal

Journals / Journal of Experimental and Clinical Medicine / 2022 / Cilt: 39 - Sayı: 2

Association between non-alcoholic fatty liver disease and endometrial cancer

Nazlı TOPFEDAİSİ ÖZKAN
İbrahim YALÇIN
Mehmet Mutlu MEYDANLI
Pages
507–510
Publication Date
2022-03-18
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In EC group, age, body masss indeks (BMI), hypertension and NAFLD were significantly higher than those in control group (P

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Metabolic syndrome (MetS) increase the risk of endometrial cancer (EC).
📊
Key Findings & Data:Non-alcoholic fatty liver disease (NAFLD) is related with MetS and share many risk factors with EC that may have significant roles in its development; however, the relationship between NAFLD and EC remains unclear. 207 patients who were operated for endometrial cancer in our hospital between 2011 and 2015, and 243 gynecological patients without a history of malignancy who were randomly selected as the control group.
💡
Conclusion & Impact:In EC group, age, body masss indeks (BMI), hypertension and NAFLD were significantly higher than those in control group (P
🔬Design:Research Article
📍Scope:2011 Verileri
⚙️Variables:endometrial cancer · non-alcoholic fatty liver disease · obesity

Abstract

Metabolic syndrome (MetS) increase the risk of endometrial cancer (EC). Non-alcoholic fatty liver disease (NAFLD) is related with MetS and share many risk factors with EC that may have significant roles in its development; however, the relationship between NAFLD and EC remains unclear. 207 patients who were operated for endometrial cancer in our hospital between 2011 and 2015, and 243 gynecological patients without a history of malignancy who were randomly selected as the control group. NAFLD was diagnosed based on abdominal ultrasonography findings. There was no significant difference presence of diabetes mellitus and ALT, AST levels between EC group and control group. In EC group, age, body masss indeks (BMI), hypertension and NAFLD were significantly higher than those in control group (P

🔖

Cite This Article

ÖZKAN, N. T., YALÇIN, İ., MEYDANLI, M. M. (2022). Association between non-alcoholic fatty liver disease and endometrial cancer. Journal of Experimental and Clinical Medicine, Cilt: 39 - Sayı: 2, 507–510. https://ajindex.com/articles/677718

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (14)

  1. Setiawan VW, Yang HP, Pike MC, McCann SE, Yu H, Xiang YB, et al. Type I and II endometrial cancers: have they different risk factors? J Clin Oncol. 2013 Jul 10;31(20):2607-18
  2. Kim JJ, Chapman-Davis E. Role of progesterone in endometrial cancer. Semin Reprod Med. 2010;28(1):81–90
  3. Bjørge T, Engeland A, Tretli S,Weiderpass E. Body size in relation to cancer of the uterine corpus in 1 million Norwegian women. Int J Cancer. 2007 Jan 15;120(2): 378–83
  4. Setiawan VW, Yang HP, Pike MC, McCann SE, Yu H, Xiang YB, et al. Type I and II endometrial cancers: have they different risk factors? J Clin Oncol. 2013;31(20):2607–18
  5. World Cancer Research Fund. Cancers linked with greater body fatness [Webpage] [Internet], 2015. http://www.wcrf.org/int/cancer-facts-figures/link-between-lifestyle-cancer-risk/cancers-linked- greater-body-fatness (cited 23 Mar 2016)
  6. Friedenreich CM, Biel RK, Lau DC, Csizmadi I, Coumeya KS, Magliocco AM, et al. Case–control study of the metabolic syndrome and metabolic risk factors for endometrial cancer. Cancer Epidemiol Biomarkers Prev. 2011;20:2384–95
  7. Rosato V, Zucchetto A, Bosetti C, Dal Maso L, Montella M, Pelucchi C, et al. Metabolic syndrome and endometrial cancer risk. Ann Oncol. 2011;22:884–9
  8. Esposito K, Chiodini P, Colao A, Lenzi A, Giugliano D. Metabolic syndrome and risk of cancer: a systematic review and meta-analysis. Diabetes Care. 2012;35(11):2402–11
  9. Della Corte C, Mosca A, Majo F, Lucidi V, Panera N, Giglioni E, et al. Nonalcoholic fatty pancreas disease and nonalcoholic fatty liver disease: more than ectopic fat. Clin Endocrinol (Oxf). 2015;83:656–62
  10. Lee DY, Lee TS. Associations between metabolic syndrome and gynecologic cancer. Obstet Gynecol Sci. 2020 May;63(3):215-224
  11. Adambekov S, Yi Y, Fabio A, Miljkovic I, Edwards RP, Lopa S, et al. Metabolic Syndrome in Endometrial Cancer Patients: Systematic Review. Metab Syndr Relat Disord. 2019 Jun;17(5):241-249
  12. Arthur RS, Kabat GC, Kim MY, Wild RA, Shadyab AH, Wactawski-Wende J, et al. Metabolic syndrome and risk of endometrial cancer in postmenopausal women: a prospective study. Cancer Causes Control. 2019 Apr;30(4):355-363
  13. Wang L, Du ZH, Qiao JM, Gao S. Association between metabolic syndrome and endometrial cancer risk: a systematic review and meta-analysis of observational studies. Aging (Albany NY). 2020 May 22;12(10):9825-9839
  14. Jin J, Dalwadi SM, Masand RP, Hall TR, Anderson ML, Ludwig MS. Association Between Metabolic Syndrome