Journals / İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi / 2022 / Sayı: 17

The Role of Some Selenoproteins in the Etiopathogenesis of Breast Cancer

Meme Kanserinin Etiyopatogenezinde Bazı Selenoproteinlerin Rolü

Pages
381–390
Publication Date
2022-08-29
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This study aims to evaluate the changes in the pre- and post-treatment selenoprotein levels of breast cancer patients who received radiotherapy and to examine the effects on the etiopathogenesis of the disease.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: Breast cancer is the second leading cause of cancer-related deaths in women, after lung cancer.
📊
Key Findings & Data:In various studies, it has been shown that selenoproteins suppress some stages of carcinogenesis and decrease the proliferation rate of cancer cells.
💡
Conclusion & Impact:This study aims to evaluate the changes in the pre- and post-treatment selenoprotein levels of breast cancer patients who received radiotherapy and to examine the effects on the etiopathogenesis of the disease.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:meme kanseri · selenoprotein · tedavi

Abstract

Aim: Breast cancer is the second leading cause of cancer-related deaths in women, after lung cancer. In various studies, it has been shown that selenoproteins suppress some stages of carcinogenesis and decrease the proliferation rate of cancer cells. However, these mechanisms have not been fully elucidated. Radiotherapy is one of the most preferred treatment methods along with chemotherapy in cancer treatment. This study aims to evaluate the changes in the pre- and post-treatment selenoprotein levels of breast cancer patients who received radiotherapy and to examine the effects on the etiopathogenesis of the disease.

Özet

Amaç: Meme kanseri, kadınlarda kanser kaynaklı ölümlerde akciğer kanserinden sonra ikinci sırada yer alır. Çeşitli çalışmalarda, selenoproteinlerin kanserogenezin bazı evrelerini baskıladığı ve kanser hücrelerinin çoğalma hızını azalttığı gösterilmiştir. Ancak bu mekanizmalar tam olarak açıklanamamıştır. Kanser tedavisinde radyoterapi, kemoterapiyle birlikte en çok tercih edilen tedavi yöntemlerindendir. Çalışmanın amacı, radyoterapi alan meme kanserli hastaların tedavi öncesi ve sonrası selenoprotein düzeylerindeki değişiklikleri değerlendirerek hastalığın etiyopatogenezine olası etkilerini incelemektir.

🔖

Cite This Article

ÖĞÜT, S., DEĞİRMENCİOĞLU, S., BAHTİYAR, N., CİNEMRE, F. B., AYDEMİR, B., KARAÇETİN, D., HACIOSMANOĞLU, E., KURAL, A., GÜNEŞ, M. E., BEKTAŞ, M. (2022). The Role of Some Selenoproteins in the Etiopathogenesis of Breast Cancer. İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi, Sayı: 17, 381–390. https://ajindex.com/articles/675866

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (4)

  1. Harris JR, Lippman ME, Veronesi U, Willett W. Medical progress: Breast cancer. The New England Journal of Medicine. 1992;327(6):390-398. doi:10.1056/NEJM199208063270606. Greenlee RT, Hill‐Harmon MB, Murray T, Thun M. Cancer statistics. CA: A Cancer. Journal for Clinicians. 2001;51(1):15-36. doi:10.3322/canjclin.51.1.15. Mahata J, Basu A, Ghoshal S, Sarkar JN, Roy AK, Poddar G, et al. Chromosomal aberrations and sister chromatid exchanges in individuals exposed to arsenic through drinking water in West Bengal. India. Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 2003;534(1-2):133-143. doi:10.1016/S1383-5718(02)00255-3.
  2. Waks AG, Winer EP. Breast cancer treatment: A review. Jama. 2019;321(3):288-300. doi:10.1001/jama.2018.19323. Aung KL, Siu LL. Genomically personalized therapy in head and neck cancer. Cancers of the Head & Neck. 2016;1(1):1-10. doi:10.1186/s41199-016-0004-y. Maxwell KN, Nathanson KL. Common breast cancer risk variants in the post-COGS era: A comprehensive review. Breast Cancer Research. 2013;15(6): 1-17. doi:210.1186/bcr3591. Brown KM, Arthur JR. Selenium, selenoproteins and human health: A review. Public health nutrition. 2001;4(2b):593-599. doi:10.1079/PHN2001143. Riaz M, Mehmood KT. Selenium in human health and disease: A review. Journal of Postgraduate Medical Institute. 2012;26(2):120-134.
  3. Mehdi Y, Hornick JL, Istasse L, Dufrasne I. Selenium in the environment, metabolism and involvement in body functions. Molecules. 2013;18(3):3292-3311. doi:10.3390/molecules 18033292. Rayman MP. Selenoproteins and human health: Insights from epidemiological data. Biochimica et Biophysica Acta (BBA)-General Subjects. 2009;1790(11):1533-1540. doi:10.1016/j.bbagen.2009.03.014. Hill KE, Wu S, Motley AK, Stevenson TD, Winfrey VP, Capecchi MR, et al. Production of selenoprotein P (Sepp1) by hepatocytes is central to selenium homeostasis. Journal of Biological Chemistry. 2012;287(48):40414-40424. doi:10.1074/jbc.M112.421404. Steinbrecher A, Méplan C, Hesketh J, Schomburg L, Endermann T, Jansen E, et al. Effects of selenium status and polymorphisms in selenoprotein genes on prostate cancer risk in a Prospective Study of European MenSelenium, SNPs, and Prostate Cancer. Cancer Epidemiology, Biomarkers & Prevention. 2010;19(11):2958-2968. doi:10.1158/1055-9965.EPI-10-0364.
  4. Strauss E, Tomczak J, Staniszewski R, Oszkinis G. Associations and interactions between variants in selenoprotein genes, selenoprotein levels and the development of abdom