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Journals / Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi / 2021 / Cilt: 11 - Sayı: 4

Development of Electrochemical Sensor for Determination of Ondansetron in Pharmaceutical Preparations

Farmasötik Preparatlarda Ondansetron Tayini İçin Elektrokimyasal Sensör Geliştirilmesi

Zehra Özden ERDOĞAN
Mustafa Barış KOÇER
Serkan SAYIN
Semahat KÜÇÜKKOLBAŞI
Pages
2860–2869
Publication Date
2021-12-15
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Analytical applicability of the sensor was investigated by determination of ondansetron in pharmaceutical preparations.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:In this study, an electrochemical sensor based on carbon nanotube immobilized with diester-functionalized calix[4]arene (CNT-Calix-DE) was developed to determine the ondansetron content in pharmaceutical preparations.
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Key Findings & Data:The surface morphology, electrochemical characterization and analytical performance of the sensor were examined using scanning electron microscope (SEM), electrochemical impedance spectroscopy (EIS) and differential pulse anodic stripping voltammetry (DPASV).
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Conclusion & Impact:Analytical applicability of the sensor was investigated by determination of ondansetron in pharmaceutical preparations.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:ondansetron · sensör · farmasötik preparat

Abstract

In this study, an electrochemical sensor based on carbon nanotube immobilized with diester-functionalized calix[4]arene (CNT-Calix-DE) was developed to determine the ondansetron content in pharmaceutical preparations. During the sensor preparation stage, the glassy carbon electrode surface was modified with CNT-Calix-DE. The surface morphology, electrochemical characterization and analytical performance of the sensor were examined using scanning electron microscope (SEM), electrochemical impedance spectroscopy (EIS) and differential pulse anodic stripping voltammetry (DPASV). Under optimal experimental conditions, the developed sensor showed a linear response to ondansetron in the concentration range of 1.0-10.0 M. Analytical applicability of the sensor was investigated by determination of ondansetron in pharmaceutical preparations.

Özet

Bu çalışmada, farmasötik preparatlardaki ondansetron içeriğinin belirlenmesi için karbon nanotüp immobilize diester-kaliks[4]arene (CNT-Calix-DE) dayalı elektrokimyasal sensör geliştirildi. Sensör hazırlama aşamasında, camsı karbon elektrot yüzeyi CNT-Calix-DE ile modifiye edildi. Sensörün yüzey morfolojisi, elektrokimyasal karakterizasyonu ve analitik performansı, taramalı elektron mikroskopu (SEM), elektrokimyasal empedans spektroskopisi (EIS) ve diferansiyel puls anodik sıyırma voltametrisi (DPASV) kullanılarak incelendi. Optimum deneysel koşullar altında, geliştirilen sensör ondansetrona karşı 1.0-10.0 µM konsantrasyon aralığında doğrusal cevap gösterdi. Sensörün analitik uygulanabilirliği farmasötik preparatlarda ondansetron tayini yapılarak araştırıldı.

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Cite This Article

ERDOĞAN, Z. Ö., KOÇER, M. B., SAYIN, S., KÜÇÜKKOLBAŞI, S. (2021). Development of Electrochemical Sensor for Determination of Ondansetron in Pharmaceutical Preparations. Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi, Cilt: 11 - Sayı: 4, 2860–2869. https://ajindex.com/articles/671819

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