SavedAdd your journal

Journals / Zeynep Kamil medical journal (Online) / 2022 / Cilt: 53 - Sayı: 3

Serum follistatin-like-3 levels in the diagnosis of tubal ectopic pregnancy

Işıl AYHAN
Ahter Tanay TAYYAR
İsmail DAĞ
Melike ALTINTAŞ
Hakan BİLGESOY
Betül YILMAZER
Pages
110–115
Publication Date
2022-11-11
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results: Serum FSTL3 levels were significantly lower in the ectopic pregnancy group than in controls (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Activin is necessary for maintaining normal pregnancy; follistatin and fol- listatin-like-3 (FSTL3) are known antagonists of activin.
📊
Key Findings & Data:FSTL3 also has a role in the migration and invasion of trophoblasts.
💡
Conclusion & Impact:Results: Serum FSTL3 levels were significantly lower in the ectopic pregnancy group than in controls (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Activin is necessary for maintaining normal pregnancy; follistatin and fol- listatin-like-3 (FSTL3) are known antagonists of activin. FSTL3 also has a role in the migration and invasion of trophoblasts. We aim to measure the value of serum FSTL3 levels in the diagnosis of tubal ectopic pregnancy. Material and Methods: Seventy-six pregnant women including 39 women with sur- gically confirmed tubal ectopic pregnancy and 37 healthy, singleton controls whose gestational ages were between 5 and 8 weeks. Serum FSTL3 levels were measured in both groups through ELISA. Receiver operator characteristic (ROC) curve analysis was performed for the prediction of tubal ectopic pregnancy using serum FSTL3. Results: Serum FSTL3 levels were significantly lower in the ectopic pregnancy group than in controls (p

🔖

Cite This Article

AYHAN, I., TAYYAR, A. T., DAĞ, İ., ALTINTAŞ, M., BİLGESOY, H., YILMAZER, B. (2022). Serum follistatin-like-3 levels in the diagnosis of tubal ectopic pregnancy. Zeynep Kamil medical journal (Online), Cilt: 53 - Sayı: 3, 110–115. https://ajindex.com/articles/655736

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (15)

  1. . Bouyer J, Coste J, Fernandez H, Pouly JL, Job-Spira N. Sites of ectopic pregnancy: A 10 year population-based study of 1800 cases. Hum Re- prod 2002
  2. 3224–30. 2. Shi Y, Massagué J. Mechanisms of TGF-beta signaling from cell mem- brane to the nucleus. Cell 2003
  3. 685–700. 3. Rebbapragada A, Benchabane H, Wrana JL, Celeste AJ, Attisano L. Myostatin signals through a transforming growth factor beta-like signal- ing pathway to block adipogenesis. Mol Cell Biol 2003
  4. 7230–42. 4. Welt C, Sidis Y, Keutmann H, Schneyer A. Activins, inhibins, and folli- statins: From endocrinology to signaling. A paradigm for the new millen- nium. Exp Biol Med (Maywood) 2002
  5. 724–52. 5. Jones KL, de Kretser DM, Clarke IJ, Scheerlinck JP, Phillips DJ. Char- acterisation of the rapid release of activin A following acute lipopolysac- charide challenge in the ewe. J Endocrinol 2004
  6. 69–80. 6. Schneyer A, Sidis Y, Xia Y, Saito S, del Re E, Lin HY, et al. Differential ac- tions of follistatin and follistatin-like 3. Mol Cell Endocrinol 2004
  7. 25– 8. 7. Ciarmela P, Florio P, Toti P, Franchini A, Maguer-Satta V, Ginanneschi C, et al. Human placenta and fetal membranes express follistatin-related gene mRNA and protein. J Endocrinol Invest 2003
  8. 641–5. 8. Kumar TR. Too many follistatins: Racing inside and getting out of the cell. Endocrinology 2005
  9. 5048–51. 9. Tortoriello DV, Sidis Y, Holtzman DA, Holmes WE, Schneyer AL. Human follistatin-related protein: A structural homologue of follistatin with nucle- ar localization. Endocrinology 2001
  10. 3426–34. 10. Hill JJ, Davies MV, Pearson AA, Wang JH, Hewick RM, Wolfman NM, et al. The myostatin propeptide and the follistatin-related gene are in- hibitory binding proteins of myostatin in normal serum. J Biol Chem 2002
  11. 40735–41. 11. Refaat B. Role of activins in embryo implantation and diagnosis of ecto- pic pregnancy: A review. Reprod Biol Endocrinol 2014
  12. Shaw JL, Dey SK, Critchley HO, Horne AW. Current knowledge of the aetiology of human tubal ectopic pregnancy. Hum Reprod Update. 2010
  13. 432–44. 13. Berg CJ, Callaghan WM, Henderson Z, Syverson C. Pregnancy-re- lated mortality in the United States, 1998 to 2005. Obstet Gynecol 2011
  14. Senapati S, Barnhart KT. Biomarkers for ectopic pregnancy and preg- nancy of unknown location. Fertil Steril 2013
  15. 1107–16. 15. Rausch ME, Sammel MD, Takacs P, Chung K, Shaunik A, Barnhart KT. Development of a multiple marker test for ectopic pregnancy. Obstet Gynec