Does COVID-19 Affect the Course of Trophoblastic Gestational Disease in Partial Hydatidiform Moles; Is It A Viral or A Pandemic?

Conclusion: During the pandemic period, along with the increase in the incidence of PHM compared to the pre-pandemic period, an increase in the incidence of progression to GTN disease was detected.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Hydatiform mole (HM) is a non-malignant form of gestational trophoblastic disease (GTD) characterized by failure of normal fetal development and overgrowth of trophoblasts.

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Key Findings & Data:With this retrospective cohort study, we planned to determine the incidence of PHM, etiology and progression rates to Gestational trophoblastic neoplasia (GTN) during the COVID-19 epidemic.

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Conclusion & Impact:Conclusion: During the pandemic period, along with the increase in the incidence of PHM compared to the pre-pandemic period, an increase in the incidence of progression to GTN disease was detected.

🔬Design:Research Article

📍Scope:2016 Verileri

⚙️Variables:Domain Parameters

Abstract

Objective: Hydatiform mole (HM) is a non-malignant form of gestational trophoblastic disease (GTD) characterized by failure of normal fetal development and overgrowth of trophoblasts. With this retrospective cohort study, we planned to determine the incidence of PHM, etiology and progression rates to Gestational trophoblastic neoplasia (GTN) during the COVID-19 epidemic. Materials and Method: This retrospective cohort study was conducted in Ankara Etlik Zübeyde Hanım Women’s Health Training and Research Hospital Early Pregnancy Assessment Unit between March 2016 and February 2022. Patients who underwent therapeutic curettage (T/C) with the diagnosis of missed abortion, intrauterine exitus (IUEX), molar pregnancy or incomplete abortion after single spontaneous pregnancy were included in the study. The study group consisted of 138 patients who were diagnosed with partial hydatiform mole as a result of pathological examination in this process. There were 135 patients in the control group. Results: The number of patients who applied during the pandemic period and were diagnosed with PHM was 62 (44.92%). The mean age of the patients in the study group was 31.97±8.26 years. The mean body mass index of these patients was 26.38±5.13 m2/kg. The mean paternal age in the study group was 34.95±8.32 years, and it was higher than the paternal age of the patients in the control group (p=0.028). While the incidence of PHM was 1.22/1000 births in our hospital in 2019, this figure was calculated as 3.79/1000 births in 2020. The incidence of progression to GTN at 4 years before the pandemic was 0.02/1000 births; In 2020- 2021, this rate was calculated as 0.25/1000 births. Conclusion: During the pandemic period, along with the increase in the incidence of PHM compared to the pre-pandemic period, an increase in the incidence of progression to GTN disease was detected.

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Cite This Article

İBANOĞLU, M. C., ERGANİ, S. Y., UZUNOĞLU, İ. Ö., UÇUK, B. S., REİS, Y. A., YÜCEL, K. Y., İSKENDER, C., ÜSTÜN, Y. E. (2022). Does COVID-19 Affect the Course of Trophoblastic Gestational Disease in Partial Hydatidiform Moles; Is It A Viral or A Pandemic?. Acta Medica, Cilt: 53 - Sayı: 3, 292–298. https://ajindex.com/articles/655448

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References (14)

Szulman AE, Surti U. The syndromes of hydatidiform mole: I. Cytogenetic and morphologic correlations. American journal of obstetrics and gynecology 1978; 131(6): 665- 671
Nguyen NM, Bolze PA, Slim R. Hydatidiform moles. In: Hashkes PJ, Laxer RM, Simon A, eds. Textbook of Autoinflammation. Cham, Switzerland: Springer; 2019:485-497
Berkowitz RS, Goldstein DP. Molar pregnancy. New England journal of medicine 2009;360(16): 1639-1645
De Franciscis P, Schiattarella A, Labriola D, et al. A partial molar pregnancy associated with a fetus with intrauterine growth restriction delivered at 31 weeks: a case report. Journal of medical case reports 2019; 13(1): 1-5
Sundara YT, Jordanova ES, Hernowo BS, Gandamihardja S, Fleuren GJ. Decidual infiltration of FoxP3+ regulatory T cells, CD3+ T cells, CD56+ decidual natural killer cells and Ki-67 trophoblast cells in hydatidiform mole compared to normal and ectopic pregnancies. Molecular Medicine Reports 2012; 5(1): 275-281
Hussein MR, Abd-Elwahed AR, Abodeif ES, Abdulwahed SR. Decidual immune cell infiltrate in hydatidiform mole. Cancer investigation 2009; 27(1): 60-66
Verit FF, Hilali NG. Increased insulin resistance and C-reactive protein in women with complete hydatidiform mole. Gynecological Endocrinology 2011; 27(10): 840-843
Alex S, Panikkar B, Shyamala PK, Balaram P. Viral etiology of Complete Hydatidiform Moles. Indian Journal of Biotechnology 2002; 1(2): 175-179
Bartas M, Brázda V, Bohálová N, et al. In-depth bioinformatic analyses of nidovirales including human SARS-CoV-2, SARS-CoV, MERS-CoV viruses suggest important roles of non-canonical nucleic acid structures in their lifecycles. Frontiers in microbiology 2020; 11: 1583
Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. The lancet 2020; 395(10223): 507-513
Ramljak D, Vukoja M, Curlin M, et al. Early Response of CD8+ T Cells in COVID-19 Patients. Journal of Personalized Medicine 2021; 11(12): 1291
Jin Y, Yang H, Ji W, et al. Virology, epidemiology, pathogenesis, and control of COVID-19. Viruses 2020; 12(4): 372
Bouachba A, Allias F, Nadaud B, et al. Placental lesions and SARS-Cov-2 infection: Diffuse placenta damage associated to poor fetal outcome. Placenta 2021; 112: 97-104
Celik OY, Çelen Ş, Üstün YE. Did the SARS-CoV-2 effect pregnancy complications? Ginekologia polska 2021;92