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Journals / Ulusal Travma ve Acil Cerrahi Dergisi / 2022 / Cilt: 28 - Sayı: 6

Protective role of melatonin against testicular damage caused by polymicrobial sepsis in adult rats

Songul Doganay
Ozcan Budak
Veysel Toprak
Gulay Erman
Arzu Sahin
Pages
723–729
Publication Date
2022-11-07
DOI
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There was a significant decrease in sperm density, motility and cell numbers with normal morphology (p

📌 3 Key Takeaways

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Objective & Hypothesis:BACKGROUND: This study aimed to investigate the possible protective effects of melatonin (MEL) against the damage to testicular tissue in rats caused by polymicrobial sepsis as a result of cecal ligation and perforation (CLP).
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Key Findings & Data:METHODS: In this study, 21 male Wistar albino rats were used.
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Conclusion & Impact:There was a significant decrease in sperm density, motility and cell numbers with normal morphology (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

BACKGROUND: This study aimed to investigate the possible protective effects of melatonin (MEL) against the damage to testicular tissue in rats caused by polymicrobial sepsis as a result of cecal ligation and perforation (CLP). METHODS: In this study, 21 male Wistar albino rats were used. The rats were randomly divided into three groups (n=7): Sham Control (Group 1), CLP (Group 2), and CLP + MEL (Group 3). Sepsis was created using the CLP method. MEL was administered intraperitoneally in two equal doses of 10 mg/kg at 30 min before and 6 h after perforation. Tissue sections taken from paraffin blocks were stained with hematoxylin and eosin (H and E) and examined histopathologically under a light microscope. Intracellular H2O2 and apoptosis evaluations were carried out using the flow cytometric method. RESULTS: Sepsis caused a significant reduction in all sperm parameters. There was a significant decrease in sperm density, motility and cell numbers with normal morphology (p

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Cite This Article

Doganay, S., Budak, O., Toprak, V., Erman, G., Sahin, A. (2022). Protective role of melatonin against testicular damage caused by polymicrobial sepsis in adult rats. Ulusal Travma ve Acil Cerrahi Dergisi, Cilt: 28 - Sayı: 6, 723–729. https://ajindex.com/articles/655445

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