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Journals / Ulusal Travma ve Acil Cerrahi Dergisi / 2022 / Cilt: 28 - Sayı: 6

Neuroprotective effects of adrenomedullin in experimental traumatic brain injury model in rats

Gökçen Emmez
Erkut Baha Bulduk
Zuhal Yıldırım
Pages
736–742
Publication Date
2022-11-07
DOI
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RESULTS: In the trauma group, both tissue and serum MDA, TNF-α, and IL-6 levels were significantly increased compared to the control group (p

📌 3 Key Takeaways

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Objective & Hypothesis:BACKGROUND: Traumatic brain injuries cause damages in the brain in several ways, which include cell death because of edema, disruption of the blood–brain barrier, shear stress, and ischemia.
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Key Findings & Data:METHODS: Eighteen male adult Wistar albino rats were randomized into three groups (n=6).
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Conclusion & Impact:RESULTS: In the trauma group, both tissue and serum MDA, TNF-α, and IL-6 levels were significantly increased compared to the control group (p
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

BACKGROUND: Traumatic brain injuries cause damages in the brain in several ways, which include cell death because of edema, disruption of the blood–brain barrier, shear stress, and ischemia. In this study, we investigated the effects of adrenomedullin (AM) on oxidative stress and inflammation after head traumas in a rat model. METHODS: Eighteen male adult Wistar albino rats were randomized into three groups (n=6). No traumas were applied to the con- trol (C) group. Traumas were applied in line with Marmarau trauma model in the trauma group. The rats in the AM treatment group were treated with post-traumatic 12 μg/kg i.p. AM in addition to the trauma group. The rats were followed for 7 days in all groups and were then sacrificed. Brain tissues and blood samples were taken. RESULTS: In the trauma group, both tissue and serum MDA, TNF-α, and IL-6 levels were significantly increased compared to the control group (p

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Cite This Article

Emmez, G., Bulduk, E. B., Yıldırım, Z. (2022). Neuroprotective effects of adrenomedullin in experimental traumatic brain injury model in rats. Ulusal Travma ve Acil Cerrahi Dergisi, Cilt: 28 - Sayı: 6, 736–742. https://ajindex.com/articles/655426

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