Journals / Türkiye Acil Tıp Dergisi / 2007 / Cilt: 7 - Sayı: 3

Lethal toxicity of propafenone in a case suicidal attempt

Ölümle sonuçlanan akut propafenon toksisitesi

Pages
132–135
Publication Date
2022-11-05
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this study, we present one case of suicidal attempt acute toxicity 7500 mg of propafenone that proceeded mortal and review the literature on this subject.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Propafenone is a well-established IC class antiarrhythmic drug widely used in the treatment of a variety of supraventricular and ventricular tachyarrhythmias.
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Key Findings & Data:As a class IC antiarrhythmic agent it may show a significant proarrhythmogenic effect even at therapeutic doses.
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Conclusion & Impact:In this study, we present one case of suicidal attempt acute toxicity 7500 mg of propafenone that proceeded mortal and review the literature on this subject.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Propafenone is a well-established IC class antiarrhythmic drug widely used in the treatment of a variety of supraventricular and ventricular tachyarrhythmias. Propafenone has been widely used in clinical practice in recent years. As a class IC antiarrhythmic agent it may show a significant proarrhythmogenic effect even at therapeutic doses. Toxic effects of high doses including fatal outcome have been sporadically described in the literature. Fatal course is usually associated with cardiac conduction abnormalities with progression to asystole or electromechanical dissociation. Since a specific treatment is not available and resuscitation techniques may be of limited value, early diagnosis and primary detoxication are essential. In this study, we present one case of suicidal attempt acute toxicity 7500 mg of propafenone that proceeded mortal and review the literature on this subject.

Özet

Propafenon, supraventriküler ve ventriküler taşiaritmi tedavisinde kullanılan etkinliği kanıtlanmış sınıf IC anti aritmik bir ilaçtır ve son yıllarda klinik pratikte yaygın olarak kullanılmaktadır. Sınıf IC anti aritmik ajan olmasına rağ- men tedavi dozunda önemli proaritmik etkileri gözlenebilir. Yüksek dozlara bağlı ölümü de kapsayan toksik etkileri literatürlerde sporadik olarak bildirilmiştir. Ölüm olayı genellikle nabızsız elektriksel aktivite veya asistoliyi içeren kardiyak durum anormallikleriyle ilişkilidir. Spesifik tedavisinin olmaması ve resüsitasyon tekniklerinin sınırlı düzeyde olmasına rağmen erken tanı ve primer detoksifikasyon gereklidir. Biz bu çalışmada intahar amaçlı 7500 mg propafenon alan ve mortal seyreden bir olguyu, literatür ışığı altında irdelemeyi amaçladık.

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Cite This Article

ÖZHASENEKLER, A., GÜLOĞLU, C., ORAK, M., ÜSTÜNDAĞ, M., DURGUN, H. M. (2022). Lethal toxicity of propafenone in a case suicidal attempt. Türkiye Acil Tıp Dergisi, Cilt: 7 - Sayı: 3, 132–135. https://ajindex.com/articles/654863

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