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Journals / Turkish Journal of Pediatrics / 2017 / Cilt: 59 - Sayı: 2

Drug reaction with eosinophilia and systemic symptoms in a child on multiple antiepileptics

Jyotindra Narayan GOSWAMI
Pankaj C. VAIDYA
Arushi Gahlot SAINI
Dipankar DE
Bishan Dass RADOTRA
Pratibha D. SINGHI
Pages
197–199
Publication Date
2022-11-05
DOI
—
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Our case highlightsthe importance of early suspicion for diagnosis of pediatric DRESS, avoidanceof polytherapy and institution of early immunomodulation to improve theoutcomes in children in this condition.

📌 3 Key Takeaways

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Objective & Hypothesis:Drug reaction with eosinophilia and systemic symptoms (DRESS) is anadverse drug-reaction that may mimic systemic illnesses and have a fulminantpresentation.
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Key Findings & Data:We describe an 8-year-old girl with epilepsy and exposure tomultiple anti-epileptics who presented with fever, extensive maculopapular rash,cervical lymphadenopathy, hepatomegaly, progressive anemia and transaminitis.Infections, autoimmune disorders and hematological or reticuloendothelialmalignancies were excluded.
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Conclusion & Impact:Our case highlightsthe importance of early suspicion for diagnosis of pediatric DRESS, avoidanceof polytherapy and institution of early immunomodulation to improve theoutcomes in children in this condition.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Drug reaction with eosinophilia and systemic symptoms (DRESS) is anadverse drug-reaction that may mimic systemic illnesses and have a fulminantpresentation. We describe an 8-year-old girl with epilepsy and exposure tomultiple anti-epileptics who presented with fever, extensive maculopapular rash,cervical lymphadenopathy, hepatomegaly, progressive anemia and transaminitis.Infections, autoimmune disorders and hematological or reticuloendothelialmalignancies were excluded. Based on the proposed diagnostic criteria, adiagnosis of DRESS was concluded. Her skin biopsy showed atypical findingsconsistent with erythema multiforme. Suspected anti-epileptic drugs werediscontinued. She was administered pulse methyl-prednisolone therapy andbroad-spectrum antibiotics along with adequate supportive management.Unfortunately, the child succumbed to nosocomial sepsis. Our case highlightsthe importance of early suspicion for diagnosis of pediatric DRESS, avoidanceof polytherapy and institution of early immunomodulation to improve theoutcomes in children in this condition.

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Cite This Article

GOSWAMI, J. N., VAIDYA, P. C., SAINI, A. G., DE, D., RADOTRA, B. D., SINGHI, P. D. (2022). Drug reaction with eosinophilia and systemic symptoms in a child on multiple antiepileptics. Turkish Journal of Pediatrics, Cilt: 59 - Sayı: 2, 197–199. https://ajindex.com/articles/654520

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References (10)

  1. Cacoub P, Musette P, Descamps V, et al. The DRESS syndrome: A literature review. Am J Med 2011; 124: 588-597
  2. Criado PR, Criado RF, Avancini JM, Santi CG. Drug reaction with eosinophilia and systemic symptoms (DRESS) / Drug-induced hypersensitivity syndrome (DIHS): A review of current concepts. An Bras Dermatol 2012; 87: 435-449
  3. Kardaun SH, Sidoroff A, Valeyrie-Allanore L, et al. Variability in the clinical pattern of cutaneous sideeffects of drugs with systemic symptoms: does a DRESS syndrome really exist? Br J Dermatol 2007; 156: 609-611
  4. Hall DJ, Fromm JS. Drug reaction with eosinophilia and systemic symptoms syndrome in a patient taking phenytoin and levetiracetam: a case report. J Med Case Reports 2013; 7: 2-3
  5. Choudhary S, McLeod M, Torchia D, Romanelli P. Drug Reaction with eosinophilia and systemic symptoms (DRESS) syndrome. J Clin Aesthetic Dermatol 2013; 6: 31-37
  6. Creamer D, Walsh SA, Dziewulski P, et al. UK guidelines for the management of Stevens-Johnson syndrome/toxic epidermal necrolysis in adults 2016. J Plast Reconstr Aesthetic Surg 2016; 69: 119-153
  7. Solensky R,Khan DA,Bernstein IL,et al. Drug Allergy: An Updated Practice Parameter Endorsed by: American Academy of Allergy, Asthma and Immunology, the American College of Allergy, Asthma and Immunology, and the Joint Council of Allergy, Asthma and Immunology. Ann Allergy Asthma Immunol 2010; 105: 259-273
  8. Descamps V, Ben Saïd B, Sassolas B, et al. Management of drug reaction with eosinophilia and systemic symptoms (DRESS). Ann Dermatol Vénéréologie 2010; 137: 703-708
  9. Daly AK. Pharmacogenomics of adverse drug reactions. Genome Med 2013; 5: 5-6
  10. Chung WH, Hung SI, Hong HS, et al. Medical genetics: a marker for Stevens-Johnson syndrome. Nature 2004; 428: 486.