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Journals / Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi / 2022 / Cilt: 12 - Sayı: 1

Morphological characteristics of Calendula officinalis L. plant, development and in vitro evaluation of extract loaded topical drug formulation

Calendula officinalis L. bitkisinin morfolojik özellikleri, ekstre içeren topikal ilaç formülasyonu geliştirilmesi ve in vitro değerlendirilmesi

Umay Merve Güven
Selen Arslan
Melike Betül Çıracı
Serpil Demirci Kayıran
Pages
105–115
Publication Date
2022-11-06
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The studied microemulsions showed good stability.Conclusion: Calendula officinalis extract loaded microemulsion system may be a promising carrier for further development into a topical formulation and clinical trials in the treatment of psoriasis.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: This work aimed to develop microemulsion which can be used as vehicles for the topical application of Calendula officinalis extract.
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Key Findings & Data:The developed formulations have shown a globule size of 208.24±2.28, 232.66±4.46 and 254.82±6.84 nm, a polydispersity index of 0.22±0.04, 0.27±0.03, and 0.26±0.03, pH 5.40±0.10, 5.62±0.12, and 5.58±0.08.
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Conclusion & Impact:The studied microemulsions showed good stability.Conclusion: Calendula officinalis extract loaded microemulsion system may be a promising carrier for further development into a topical formulation and clinical trials in the treatment of psoriasis.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Calendula officinalis · topikal formülasyon · mikroemülsiyon

Abstract

Aim: This work aimed to develop microemulsion which can be used as vehicles for the topical application of Calendula officinalis extract. The morphological evaluation and traditional uses of C. officinalis were given in this study.Methods: The plant specimens of C. officinalis were collected from the botanical garden and deposited in the herbarium. The pseudo-ternary phase diagrams were constructed based on oil and a combination of different surfactant/cosurfactant at different ratios. The selected microemulsions were then characterized for droplet size, polydispersity index, pH, zeta potential and rheology.Results: Calendula officinalis extract loaded stable microemulsions were successfully formulated based on the selected compositions from the phase diagrams. The developed formulations have shown a globule size of 208.24±2.28, 232.66±4.46 and 254.82±6.84 nm, a polydispersity index of 0.22±0.04, 0.27±0.03, and 0.26±0.03, pH 5.40±0.10, 5.62±0.12, and 5.58±0.08. The formulations appeared transparent and the zeta potential result was neutral. The studied microemulsions showed good stability.Conclusion: Calendula officinalis extract loaded microemulsion system may be a promising carrier for further development into a topical formulation and clinical trials in the treatment of psoriasis.

Özet

Amaç: Çalışmamızda Calendula officinalis'in morfolojik değerlendirmesi ve geleneksel kullanımları verilmiştir. Hazırlanan Calendula officinalis ekstresinin topikal uygulabilmesi için taşıyıcı olarak kullanılabilecek mikroemülsiyon geliştirmesi amaçlanmıştır. Yöntem: Calendula officinalis'in bitki örnekleri botanik bahçesinden toplanmış ve herbaryuma yerleştirilmiştir. Üçgen faz diyagramları, yağ ve farklı oranlarda farklı yüzey aktif madde/yardımcı yüzey aktif maddenin kombinasyonları kullanılarak hazırlanıştır. Seçilen mikroemülsiyonların daha sonra damlacık boyutu, polidispersite indeksi, pH, zeta potansiyeli ve reoloji açısından karakterizasyonları yapılmıştır. Bulgular: Faz diyagramlarından elde edilen Calendula officinalis ekstresi yüklü kararlı mikroemülsiyonlar başarılı şekilde formüle edilmiştir. Geliştirilen formülasyonlar, 208.24 ± 2.28, 232.66 ± 4.46 ve 254.82 ± 6.84 nm damlacık boyutu, 0.22 ± 0.04, 0.27 ± 0.03 ve 0.26 ± 0.03, pH 5.40 ± 0.10, 5.62 ± 0.12 ve 5.58 ± 0.08 değerinde polidisperslik indeksi göstermiştir. Formülasyonlar şeffaf elde edilmiş ve nötr zeta potansiyel değeri göstermiştir. Mikroemülsiyonların bu çalışmada yüksek kararlılığa sahip oldukları görülmüştür. Sonuç: Calendula officinalis ekstresi yüklü mikroemülsiyon sistemin, sedef hastalığının klinik araştırmalarında ve topikal tedavisinde kullanılabilmesi için umut vaat edici bir ilaç taşıyıcı olabileceği düşünülmektedir.

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Cite This Article

Güven, U. M., Arslan, S., Çıracı, M. B., Kayıran, S. D. (2022). Morphological characteristics of Calendula officinalis L. plant, development and in vitro evaluation of extract loaded topical drug formulation. Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi, Cilt: 12 - Sayı: 1, 105–115. https://ajindex.com/articles/653171

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