Journals / Koşuyolu Heart Journal / 2020 / Cilt: 23 - Sayı: 2

Role of Mean Platelet Volume in the Development of Peripheral Artery Disease

Ortalama Trombosit Hacminin Periferik Arter Hastalığı Gelişimindeki Rolü

Pages
91–94
Publication Date
2022-11-06
DOI
—
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

The mean platelet count and MPV were also significantly higher in patients with PAD ascompared to patients without PAD (p< 0.01).Conclusion: The use of inexpensive and widely used tests such as platelet count and MPV can facilitate anearly diagnosis of the diseases with high morbidity and mortality, such as PAD.

📌 3 Key Takeaways

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Objective & Hypothesis:Introduction: The mean platelet volume (MPV) is one of several indicators of platelet activity.
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Key Findings & Data:Recent studies have shown that MPV is increased in myocardial infarction, unstable angina, and stroke.
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Conclusion & Impact:The mean platelet count and MPV were also significantly higher in patients with PAD ascompared to patients without PAD (p< 0.01).Conclusion: The use of inexpensive and widely used tests such as platelet count and MPV can facilitate anearly diagnosis of the diseases with high morbidity and mortality, such as PAD.
🔬Design:Research Article
📍Scope:2018 Verileri
⚙️Variables:Domain Parameters

Abstract

Introduction: The mean platelet volume (MPV) is one of several indicators of platelet activity. Recent studies have shown that MPV is increased in myocardial infarction, unstable angina, and stroke. Peripheral arterydisease (PAD) manifests with the narrowing or obstruction of the abdominal aorta and arteries distal to theaortic bifurcation due to progressive atherosclerosis. The objective of this study is to investigate the MPV andplatelet count in patients with PAD.Patients and Methods: This study included 67 patients aged 40-80 years who underwent elective surgery forPAD in our hospital between January 2018 and June 2019, along with a control group comprising 67 patientswithout PAD. The MPV and platelet count values were obtained from a preoperatively performed hemogramanalysis. Importantly, the groups were statistically compared in our study.Results: As compared to the control group, the patients with PAD had a significantly higher mean age (p=0.02), prevalence of diabetes mellitus (p 0.05). The mean platelet count and MPV were also significantly higher in patients with PAD ascompared to patients without PAD (p< 0.01).Conclusion: The use of inexpensive and widely used tests such as platelet count and MPV can facilitate anearly diagnosis of the diseases with high morbidity and mortality, such as PAD.

Özet

Giriş: Ortalama trombosit hacmi (OTH) trombosit aktivitesini gösteren parametrelerden biridir. OTH düzeyinin miyokart enfarktüsünde, unstabil anjinada ve inme durumunda arttığı son yıllarda yapılan çalışmalarda gösterilmiştir. Periferik arter hastalığı (PAH) da ilerleyici aterosklerozun sonucu olarak, abdominal aort ve aortun bifurkasyon seviyesinin distalindeki arterlerde daralma veya tıkanıklık ile kendini gösteren bir hastalıktır. Bu çalışmada PAH’ın tespitinde ve takibinde OTH’nin ve trombosit değerinin rolünün araştırılması amaçlanmıştır. Hastalar ve Yöntem: Çalışmaya Ocak 2018-Haziran 2019 tarihleri arasında hastanemizde PAH nedeniyle elektif olarak opere olan 40-80 yaş arasında 67 hasta dahil edildi. Aynı tarihlerde PAH ve koroner arter hastalığı dışında kardiyak cerrahi geçiren 67 hasta ise kontrol grubu olarak seçildi. Operasyon öncesinde yapılan hemogram tetkiklerindeki OTH değerleri ve trombosit sayıları kaydedilerek istatistiksel olarak incelendi. Bulgular: PAH pozitif hastalarda yaş ortalaması, diabetes mellitus pozitifliği, antiagregan ve sigara kullanım sıklığı, PAH negatif hastalara göre anlamlı düzeyde daha yüksekti. Çalışmada gruplar arasında diğer klinik özellikler açısından istatistiksel olarak anlamlı bir fark saptanmamıştır (p> 0.05). PAH pozitif hastalarda ortalama trombosit sayısı ve OTH düzeyleri, PAH negatif hastalara göre istatistiksel olarak anlamlı düzeyde daha yüksek tespit edilmiştir (p< 0.01). Sonuç: PAH gibi morbidite ve mortalitesi yüksek olan hastalıklarda, trombosit sayısı ve OTH gibi ucuz ve yaygın olarak kullanılan tetkiklerin kullanımı PAH gelişiminde erken tanıda yardımcı olabilir.

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Cite This Article

ÖZCANLIOĞLU, D. M., BALKAN, B., AYDIN, Ü. (2022). Role of Mean Platelet Volume in the Development of Peripheral Artery Disease. Koşuyolu Heart Journal, Cilt: 23 - Sayı: 2, 91–94. https://ajindex.com/articles/653022

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