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Journals / Journal of the Turkish-German Gynecological Association / 2012 / Cilt: 13 - Sayı: 1

Endometrium kanserli olgularda tümör anjiogenezinin HIF-1 alfa ve mikrodamar dansitesi ile değerlendirilmesi

The investigation of tumoral angiogenesis with HIF- 1 alpha and microvessel density in women with endometrium cancer

Cenk SAYIN
Füsun VAROL
Şemsi ALTANER
Aysun AYBATLI
Petek Balkanlı KAPLAN
Necdet SÜT
Pages
37–44
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

HIF-1α expression was highly correlated with CD34 expression in the tumor cells (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Hypoxia inducible factor 1 alpha (HIF-1α) is a nuclear protein upregulated in response to reduced cellular oxygen concentration which therefore acts as a marker for hypoxia.
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Key Findings & Data:The aim of this study was to determine tumoral angiogenesis with immunohistochemical markers in endometrium cancer and its relation with stage, grade, survival rates and other prognostic factors.
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Conclusion & Impact:HIF-1α expression was highly correlated with CD34 expression in the tumor cells (p
🔬Design:Research Article
📍Scope:2001 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: Hypoxia inducible factor 1 alpha (HIF-1α) is a nuclear protein upregulated in response to reduced cellular oxygen concentration which therefore acts as a marker for hypoxia. The aim of this study was to determine tumoral angiogenesis with immunohistochemical markers in endometrium cancer and its relation with stage, grade, survival rates and other prognostic factors. Material and Methods: Using the database in our Gynecologic Oncology clinic, we selected 94 patients who were diagnosed with endometrial cancer and underwent primary surgery at our institution between 2001 and 2010. Tissue microarrays believed to demonstrate the optimum part of the tumor were reprepared from the paraffin blocks. Angiogenesis and microvessel density (MVD) were investigated with the aid of HIF-1α and CD34 antibodies. Results: High expression of HIF-1α was significantly more frequent in advanced grade endometrial cancers (p=0.044). HIF-1α expression was highly correlated with CD34 expression in the tumor cells (p

Özet

Amaç: Hipoksi ile indüklenen faktör-1α (HIF-1 α) bir nükleer proteindir ve azalan hücre içi oksijen konsantrasyonuna cevap olarak regüle edilir. Bu nedenle bir hipoksi belirteci gibi görev yapar. Bu çalışmanın amacı endometrium kanserli olgularda tümör anjiogenezini immunohistokimyasal belirteçler ile incelemek ve evre, derece ve sağkalım gibi prognostik faktörlerle olan bağlantısını aydınlatmaya çalışmaktır. Gereç ve Yöntemler: 2001 ile 2010 tarihleri arasında Jinekolojik Onkoloji Bölümü’nde endometrium kanseri nedeniyle tanı alan ve ameliyat edilen 94 olgu çalışmaya dahil edildi. Olguların tümörü en iyi gösterdiğine inanılan kesitlerinin parafin blokları tekrar oluşturulup, HIF-1α ve CD34 antikorları kullanılarak anjiogenez ve mikrodamar dansitesi (MDD) değerlendirildi. Bulgular: HIF-1α pozitifliği ile yüksek grada sahip endometrium kanserli olgular arasındaki fark istatistiksel olarak anlamlı idi (p=0.044). Kullanılan immunohistokimyasal belirleyicilerin boyanma sonuçları birbiri ile karşılaştırıldığında HIF-1α pozitifliği izlenen olgularda CD34 ekspresyonunun daha fazla olduğu görüldü (p

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Cite This Article

SAYIN, C., VAROL, F., ALTANER, Ş., AYBATLI, A., KAPLAN, P. B., SÜT, N. (2022). Endometrium kanserli olgularda tümör anjiogenezinin HIF-1 alfa ve mikrodamar dansitesi ile değerlendirilmesi. Journal of the Turkish-German Gynecological Association, Cilt: 13 - Sayı: 1, 37–44. https://ajindex.com/articles/652613

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References (6)

  1. Kurman RJ. Blaustein’s Pathology of the Female Genital Tract, 5th Ed. Springer: New York, 2002: pp. 501-60
  2. Hecht LJ, Mutter GL. Molecular and pathologic aspects of endometrial carcinogenesis. J Clin Oncol 2006; 24: 4783-91. [CrossRef] 3. Harris AL. Hypoxia - a key regulatory factor in tumour growth. Nat Rev Cancer 2002; 2: 38-47. [CrossRef] 4. Wang GL, Jiang BH, Rue EA, Semenza, GL. Hypoxia-inducible factor 1 is a basic-helix-loophelix- PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA 1995; 92: 5510-14. [CrossRef] 5. Semenza GL. Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology. Trends Mol Med 2001; 7: 345-50. [CrossRef] 6. Zhong H, De Marzo A, Laughner E, Lim M, Hilton DA, Zagzag D, et al. Overexpression of hypoxia-inducible factor 1a in common human cancers and their metastases. Cancer Res 1999; 59: 5830-35
  3. Horrée N, van Diest PJ, van der Groep P, Sie-Go DM, Heintz AP. Hypoxia and angiogenesis in endometrioid endometrial carcinogenesis. Cell Oncol 2007; 29: 219-27
  4. Tavassoli FA, Devilee P. Tumours of the uterine corpus. In: Tavassoli FA, Devilee P. World Health Organization Classification of Tumours of the Breast and Female Genital Organs. Germany: IARC Press 2003. pp. 217-57
  5. Kim HS, Song YS. International Federation of Gynecology and Obstetrics (FIGO) staging system revised: what should be considered critically for gynecologic cancer? J Gynecol Oncol 2009; 20: 135-6. [CrossRef] 10. Yoshimura H, Dhar DK, Kohno H, Kubota H, Fujii T, Ueda S, et al. Prognostic impact of hypoxia-inducible factors 1alpha and 2alpha in colorectal cancer patients: correlation with tumor angiogenesis and cyclooxygenase-2 expression. Clin Cancer Res 2004; 10: 8554-60. [CrossRef] 11. Weidner N, Semple JP, Welch WR, Folkman J. Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma. N Engl J Med 1991; 324: 1-8. [CrossRef] 12. Airley R, Loncaster J, Davidson S, Bromley M, Roberts S, PattersonA, et al. Glucose transporter glut-1 expression correlates with tumor hypoxia and predicts metastasis-free survival in advanced carcinoma of the cervix. Clin Cancer Res 2001; 7: 928-34
  6. No JH, Jo H, Kim SH, Park IA, Kang D, Han SS, et al. Expression of vascular endothelial growth factor and hypoxia inducible factor- 1α in cervical neoplasia. Ann N Y Acad Sci 2009; 1171: 105-10. [CrossRef] 14. Hung JJ, Yang MH, Hsu HS, Hsu WH, Liu JS, Wu KJ. Prognostic significance of hypoxia-inducible factor-1 a, TWIST1 and