Addition of ketamine to patient-controlled analgesia with pethidine

Objective & Hypothesis:In this study, we have investigated the effects of ketamine addition in patient-controlled analgesia with petidine for patients operated for orthopedic problems.Groups have been randomyl divided; group P (pethidine) (n:50), group PK (pethidine with ketamine) (n:50), 100 patients in ASA I-II have been included in the study.

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Key Findings & Data:Maintenance of general anaesthesia with O2/N2O/Sevoflurane and fentanylas opioid have been used.

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Conclusion & Impact:T- test and Mann-Whitney U-Wilcoxon Test in SPSS Windows program have been used for statistical analysis and p

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Abstract

In this study, we have investigated the effects of ketamine addition in patient-controlled analgesia with petidine for patients operated for orthopedic problems.Groups have been randomyl divided; group P (pethidine) (n:50), group PK (pethidine with ketamine) (n:50), 100 patients in ASA I-II have been included in the study. Maintenance of general anaesthesia with O2/N2O/Sevoflurane and fentanylas opioid have been used. In the postoperative period in group P; loading dose: 50 mg, basal infusion 1 mg/hr, bolus dose 5 mg, lock-out time: 15 min have been programmed andin the group PK 2.5 µgr/kg/min of ketamine have been added into the same programe. During yhis application, VAS (Visual Analoge Scale), sedation sscore (SS), heart rate (HR), respiration rate (RR), value of analgesic demanded, cumulative drug consumption and side effects have been recorded in the postoperative 30th min, 2nd, 6th, 12th and 24th hours. T- test and Mann-Whitney U-Wilcoxon Test in SPSS Windows program have been used for statistical analysis and p

Özet

Bu çalışmada, ortopedik cerrahi geçiren olgularda, petidin ile hasta-kontrollü analjezi (HKA) uygulamasına ketamin ilavesinin etkilerini inceledik.Gruplar rastgele ayrılarak; grup P (petidin) (n:50), grup PK (petidin+ketamin) (n:50) ASA I-II toplam 100 olgu çalışmaya alındı. Tüm olgulara O2/N2O/Sevoflorane ile genel anestezi idamesi yapılıp, opioid olarak fentanil kullanıldı. Postoperatif Grup P de; petidinin yükleme dozu;50 mg, bazal infüzyon 1 mg/st, istek dozu 5 mg, kilitli kalma süresi 15 dk olarak programlandı ve grup PK'da ayni programa ketamin 2.5 µgr/kg/dk olarak ilave edildi. Uygulama boyunca, VAS (Visuel Analog Skala), sedasyon skoru (SS), kalp tepe atımı (KTA), solunum sayısı (Sol. S), analjezik istek sayısı, kullanılan toplam ilaç miktarları ve yan etkiler, postoperatif 30. dk., 2. 6. 12. 24. saatlerde kaydedildi. İstatistiksel analizler SPSS Window programında t-testi ve Mann-Whitney U-Wilcoxon testi ile yapıldı ve p

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Cite This Article

ALTAN, A., ÖZYUVACI, E., ERTÜRK, S., CANBAZ, N., GÜRBÜZ, S., ULUÇ, A., ÖZTÜRK, S. (2022). Addition of ketamine to patient-controlled analgesia with pethidine. Göztepe Tıp Dergisi, Cilt: 18 - Sayı: 3, 154–156. https://ajindex.com/articles/651102

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