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Journals / Ege Klinikleri Tıp Dergisi / 2020 / Cilt: 58 - Sayı: 1

Histopathological Findingsin Coronavirus Disease

Koronavirüs Hastalığında Histopatolojik Bulgular

Melek ÜNÇEL
Özgür İlhan ÇELİK
Pages
62–65
Publication Date
2022-11-06
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Coronavirus-2019diseasehasemergedasaglobalpublichealthproblemaffectingtheworldtodayandthedataonitsetiology,pathogenesisanditshistopathologicalfindingsareverylimited.Pathologicalfindingsofthediseasearebasedonlimitedpostmortemautopsydata.However,itisknownthattherearenonspecificchangesespeciallyinthelungsintheearlystagesofinfection.Histopathologically,diffusealveolardamageisconsideredthemostcharacteristicfinding.Whileacutephasefindingsarepresentincasesthatarelostinthefirst2weeksofthedisease,inadditiontoorganisation,fibrosisandvascularthrombosisareobservedinthosewhoarelostafterlongertreatment.AsinSARSdisease,itisknownthatlymphocytesaredepressedandareaswithhemorrhagicnecrosisareseeninthespleenandlymphnodesinCOVID-19patients.ParticlesofCoronaviruscanbedetectedinthecellbydifferentmethods.Althoughnasopharyngealswabsamplesorlungbrushbiopsiesaremorefrequentlypreferredfordiagnosis,nCoV-19canbedetectedbyimmunohistochemicalantigenesorcanbedemonstratedinpostmortemsamplesbyPCR(polymerasechainreaction)method.

📌 3 Key Takeaways

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Objective & Hypothesis:Coronavirus-2019diseasehasemergedasaglobalpublichealthproblemaffectingtheworldtodayandthedataonitsetiology,pathogenesisanditshistopathologicalfindingsareverylimited.Pathologicalfindingsofthediseasearebasedonlimitedpostmortemautopsydata.However,itisknownthattherearenonspecificchangesespeciallyinthelungsintheearlystagesofinfection.Histopathologically,diffusealveolardamageisconsideredthemostcharacteristicfinding.Whileacutephasefindingsarepresentincasesthatarelostinthefirst2weeksofthedisease,inadditiontoorganisation,fibrosisandvascularthrombosisareobservedinthosewhoarelostafterlongertreatment.AsinSARSdisease,itisknownthatlymphocytesaredepressedandareaswithhemorrhagicnecrosisareseeninthespleenandlymphnodesinCOVID-19patients.ParticlesofCoronaviruscanbedetectedinthecellbydifferentmethods.Althoughnasopharyngealswabsamplesorlungbrushbiopsiesaremorefrequentlypreferredfordiagnosis,nCoV-19canbedetectedbyimmunohistochemicalantigenesorcanbedemonstratedinpostmortemsamplesbyPCR(polymerasechainreaction)method.
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Key Findings & Data:Coronavirus-2019diseasehasemergedasaglobalpublichealthproblemaffectingtheworldtodayandthedataonitsetiology,pathogenesisanditshistopathologicalfindingsareverylimited.Pathologicalfindingsofthediseasearebasedonlimitedpostmortemautopsydata.However,itisknownthattherearenonspecificchangesespeciallyinthelungsintheearlystagesofinfection.Histopathologically,diffusealveolardamageisconsideredthemostcharacteristicfinding.Whileacutephasefindingsarepresentincasesthatarelostinthefirst2weeksofthedisease,inadditiontoorganisation,fibrosisandvascularthrombosisareobservedinthosewhoarelostafterlongertreatment.AsinSARSdisease,itisknownthatlymphocytesaredepressedandareaswithhemorrhagicnecrosisareseeninthespleenandlymphnodesinCOVID-19patients.ParticlesofCoronaviruscanbedetectedinthecellbydifferentmethods.Althoughnasopharyngealswabsamplesorlungbrushbiopsiesaremorefrequentlypreferredfordiagnosis,nCoV-19canbedetectedbyimmunohistochemicalantigenesorcanbedemonstratedinpostmortemsamplesbyPCR(polymerasechainreaction)method.
💡
Conclusion & Impact:Coronavirus-2019diseasehasemergedasaglobalpublichealthproblemaffectingtheworldtodayandthedataonitsetiology,pathogenesisanditshistopathologicalfindingsareverylimited.Pathologicalfindingsofthediseasearebasedonlimitedpostmortemautopsydata.However,itisknownthattherearenonspecificchangesespeciallyinthelungsintheearlystagesofinfection.Histopathologically,diffusealveolardamageisconsideredthemostcharacteristicfinding.Whileacutephasefindingsarepresentincasesthatarelostinthefirst2weeksofthedisease,inadditiontoorganisation,fibrosisandvascularthrombosisareobservedinthosewhoarelostafterlongertreatment.AsinSARSdisease,itisknownthatlymphocytesaredepressedandareaswithhemorrhagicnecrosisareseeninthespleenandlymphnodesinCOVID-19patients.ParticlesofCoronaviruscanbedetectedinthecellbydifferentmethods.Althoughnasopharyngealswabsamplesorlungbrushbiopsiesaremorefrequentlypreferredfordiagnosis,nCoV-19canbedetectedbyimmunohistochemicalantigenesorcanbedemonstratedinpostmortemsamplesbyPCR(polymerasechainreaction)method.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Coronavirus-2019diseasehasemergedasaglobalpublichealthproblemaffectingtheworldtodayandthedataonitsetiology,pathogenesisanditshistopathologicalfindingsareverylimited.Pathologicalfindingsofthediseasearebasedonlimitedpostmortemautopsydata.However,itisknownthattherearenonspecificchangesespeciallyinthelungsintheearlystagesofinfection.Histopathologically,diffusealveolardamageisconsideredthemostcharacteristicfinding.Whileacutephasefindingsarepresentincasesthatarelostinthefirst2weeksofthedisease,inadditiontoorganisation,fibrosisandvascularthrombosisareobservedinthosewhoarelostafterlongertreatment.AsinSARSdisease,itisknownthatlymphocytesaredepressedandareaswithhemorrhagicnecrosisareseeninthespleenandlymphnodesinCOVID-19patients.ParticlesofCoronaviruscanbedetectedinthecellbydifferentmethods.Althoughnasopharyngealswabsamplesorlungbrushbiopsiesaremorefrequentlypreferredfordiagnosis,nCoV-19canbedetectedbyimmunohistochemicalantigenesorcanbedemonstratedinpostmortemsamplesbyPCR(polymerasechainreaction)method.

Özet

Koronavirus-2019hastalığıgünümüzdetümdünyayıetkileyenküreselbirhalksağlığısorunuolarakkarşımızaçıkmışolupetiyolojisi,patogeneziveyolaçtığıhistopatolojikbulgularadairverileroldukçakısıtlıdır.Hastalığadairpatolojikbulgularkısıtlıpostmortemotopsiverilerinedayanmaktadır.Ancakenfeksiyonunerkendönemlerindedeözellikleakciğerlerdespesifikolmayandeğişikliklergörüldüğübilinmektedir.Histopatolojikolarakdiffüzalveolarhasarenkarakteristikbulguolarakkabuledilmektedir.Hastalığınözellikleilk2haftalıkdönemindehayatınıkaybedenolgulardaakutfazbulgularımevcutiken,dahauzunsürelitedavisonrasındakaybedilenlerdeorganizasyonbulgularıyanısırafibrozisvevaskülertrombozlargözlenmektedir.SARShastalığındadaolduğugibiCOVID-19hastalarındadadalakvelenfnodlarındalenfositlerindepreseolduğuvehemorajiknekrozalanlarınıngörüldüğübilinmektedir.Koronavirüseaitpartiküllerhücreiçerisindefarklıyöntemlerlesaptanabilmektedir.NazofaringealsürüntüörnekleriveyaakciğerfırçabiyopsileritanıiçindahasıklıklatercihedilmeklebirliktepostmortemörneklerdenCoV-19varlığıimmunohistokimyasalolarakantijenisaptayarakyadaPCR(polimerazzincirreaksiyonu)metoduylagösterilebilmektedir. ÖteyandanbirbaşkaaçıdanelealındığındaKoronavirüs’üninaktifhalegelmesiiçinkullanılansolüsyonların%70alkolbazlıolmasıgerektiğibilinmektedir.Patolojibölümügibitazehaldegönderilenörneklerindeincelendiğitümlaboratuvarlardabiyopsiveyasitolojikmateryallerintespitiiçinkullanılanformalinsolüsyonlarıiseancakvirüsü56derecede90dakikadainaktiveetmektedir.Henüztanıalmamışasemptomatikhastalardanfarklıamaçlarlaalınanörneklerintaşınması,tespitivedeğerlendirmesüreçleribunedenleayrıcadikkatgerektirmektedir.

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Cite This Article

ÜNÇEL, M., ÇELİK, Ö. İ. (2022). Histopathological Findingsin Coronavirus Disease. Ege Klinikleri Tıp Dergisi, Cilt: 58 - Sayı: 1, 62–65. https://ajindex.com/articles/649887

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