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Journals / Van Veterinary Journal / 2018 / Cilt: 29 - Sayı: 2

Protective Mechanism of Urtica Dioicaon Carbon Tetrachloride-Induced Hepatic Encephalopathy in Rats

Urtica dioica'nın Sıçanlarda Karbon Tetraklorür ile İndüklenen Hepatik Ensefalopati Üzerine Koruyucu Mekanizması

Gülşah YILDIZ DENİZ
Pages
77–81
Publication Date
2022-11-04
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Administration of UD may have potential protective effects against CCl4-induced brain toxicity.

📌 3 Key Takeaways

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Objective & Hypothesis:Around the world, species from the genus Urticaare commonly used because of their peripheral and central medicinal effects; this is prepared as teas.
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Key Findings & Data:In recent years, it has become increasingly important to study the beneficial properties of derivatives of Urtica dioica(UD).The aim of the present study was to evaluate the effects of UD against carbon tetrachloride (CCl4) induced hepatic encephalopathy (HE).
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Conclusion & Impact:Administration of UD may have potential protective effects against CCl4-induced brain toxicity.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Around the world, species from the genus Urticaare commonly used because of their peripheral and central medicinal effects; this is prepared as teas. In recent years, it has become increasingly important to study the beneficial properties of derivatives of Urtica dioica(UD).The aim of the present study was to evaluate the effects of UD against carbon tetrachloride (CCl4) induced hepatic encephalopathy (HE). Forty-nineadult (2-months-old) male Sprague dawleyrats were used in this study. The models were established by CCl4(1mL/kg body weight; twice a week) given intraperitoneally for 8 weeks.The animals were euthanized by decapitation and rat brainswere removed to assess histopathologicchanges. Biochemical parameters were assessed in serum samples from the CCl4-treated rats. UD extracts provided significant protection against CCl4-induced brain damage by increasing the preventing alterations in biochemical serum parameters, such as the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), glutamyl transferase (GGT) and ammonia relative to the control group. Histopathological and immunohistopathological changes of the brain tissue was observed using Hematoxylin-eosin (H&E) staining and c-Fos expressionmethod. In the present study, the protective effect of UD on CCl4 toxicity was demonstrated through studies of biochemistryand immunohistopathology. Administration of UD may have potential protective effects against CCl4-induced brain toxicity.

Özet

Dünya çapında, Urtica cinsinden türler periferik ve merkezi tıbbi etkileri nedeniyle yaygın olarak kullanılmaktadır; bunlar çay olarak hazırlanır. Son yıllarda, Urtica dioica(UD) türevlerinin yararlı özelliklerini incelemek gittikçe önem kazanmıştır. Bu çalışmanın amacı, UD'nin karbon tetraklorür (CCl4) ile indüklenen hepatik ensefalopatiye (HE) karşı etkilerini değerlendirmektir. Bu çalışmada kırk dokuz yetişkin (2 aylık) erkek Sprague dawley sıçanı kullanıldı. Modeller 8 hafta boyunca intraperitoneal olarak verilen CCI4(1 mL / kg vücut ağırlığı; haftada iki kez) ile oluşturuldu. Hayvanlar başları kesilerek ötanazi edildi ve sıçan beyinleri histopatolojik değişiklikleri değerlendirmek için çıkarıldı. Biyokimyasal parametreler CCI4ile tedavi edilen sıçanlardan alınan serum örneklerinde değerlendirildi. UD ekstraktları, kontrol grubuna göre aspartat aminotransferaz (AST), alanin aminotransferaz (ALT), glutamil transferaz (GGT) ve amonyak seviyeleri gibi biyokimyasal serum parametrelerindeki önleyici değişiklikleri arttırarak CCI4'ün neden olduğu beyin hasarına karşı önemli bir koruma sağlamıştır. Hematoksilin-eozin (H & E) boyama ve c-fos ekspresyon metodu kullanılarak beyin dokusunun histopatolojik ve immünohistolojik değişiklikleri gözlendi. Bu çalışmada, UD'nin CCI4toksisitesi üzerindeki koruyucu etkisi, biyokimya ve immünohistoloji çalışmaları ile gösterilmiştir. UD'nin uygulanması CCI4'ün neden olduğu beyin toksisitesine karşı potansiyel koruyucu etkilere sahip olabilir.

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Cite This Article

DENİZ, G. Y. (2022). Protective Mechanism of Urtica Dioicaon Carbon Tetrachloride-Induced Hepatic Encephalopathy in Rats. Van Veterinary Journal, Cilt: 29 - Sayı: 2, 77–81. https://ajindex.com/articles/646020

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