SavedAdd your journal

Journals / Van Tıp Dergisi / 2019 / Cilt: 26 - Sayı: 2

The Diagnosis of Human Leukocyte Antigen Class I and Class Ii Allel In Eastern Anatolia Region

Doğuanadolu Bölgesinde İnsan Lökosit Antijen Sınıf I ve Sınıf II Alel Dağılımı

Hasan DOĞAN
Eda BALKAN
Ezgi YAŞAR
Pages
162–166
Publication Date
2022-11-05
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Consolidating the data obtainedin this study and other national data will facilitate theselection of bone marrow donors.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: The aim of our study was to investigate thefrequency of HLA class I and class II alleles in EasternAnatolia.Materials and Methods: The study included 1050unrelated bone marrow donors from the archives.
📊
Key Findings & Data:Ethical approval was obtained.Results: The most common alleles were HLA-A*02(21.1%), HLA-A*24 (18.4%), and HLA-A*03 (12.3%) inthe HLA-A locus; HLA-B*35 (20%), HLA-B*51 (18.3%),and HLA-B*44 (6.3%) in the HLA-B locus; and HLADRB1*11 (22.3%), HLA-DRB1*04 (16.2%), and HLADRB1*15 (12.4%) in the HLA-DR locus.Conclusion: Our results are consistent with the HLAantigens identified in previous studies.
💡
Conclusion & Impact:Consolidating the data obtainedin this study and other national data will facilitate theselection of bone marrow donors.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: The aim of our study was to investigate thefrequency of HLA class I and class II alleles in EasternAnatolia.Materials and Methods: The study included 1050unrelated bone marrow donors from the archives. HLAclass I and II polymorphisms were identified usingpolymerase chain reactions (PCR) using sequencespecific primers (SSP) and sequence-specificoligonucleotides (SSO). Ethical approval was obtained.Results: The most common alleles were HLA-A*02(21.1%), HLA-A*24 (18.4%), and HLA-A*03 (12.3%) inthe HLA-A locus; HLA-B*35 (20%), HLA-B*51 (18.3%),and HLA-B*44 (6.3%) in the HLA-B locus; and HLADRB1*11 (22.3%), HLA-DRB1*04 (16.2%), and HLADRB1*15 (12.4%) in the HLA-DR locus.Conclusion: Our results are consistent with the HLAantigens identified in previous studies. We believe thatour study will contribute to the determination of HLAdiversity in our region. Consolidating the data obtainedin this study and other national data will facilitate theselection of bone marrow donors.

Özet

Amaç: Çalışmamızın amacı Doğu Anadolu bölgesindeki HLA sınıf I ve sınıf II alelerinin sıklığının araştırılmasıdır. Gereç ve Yöntemler: Çalışmaya aralarında herhangi bir akrabalık ilişkisi olmayan 1050 kemik iliği vericisi alındı. HLA sınıf I ve II polimorfizmleri, polimeraz zincir reaksiyonu (PCR) metodu ile sekansa özgü primerler (SSP) ve sekansa spesifik oligonükleotidler (SSO) kullanılarak belirlendi. Etik kurul onayı alınmıştır. Bulgular: En yaygın aleller, HLA-A lokusunda, HLAA*02 (21,1%), HLA-A*24 (18,4%), HLA-A*03 (12,3%), HLA-B lokusunda HLA-B*35 (20%), HLA-B*51 (18,3%), HLA-B*44 (6,3), HLA-DR lokusunda HLA-DRB1*11 (22,3%), HLA-DRB1*04 (16,2%), HLA-DRB1*15 (12,4%) olarak belirlendi. Sonuç: Çalışma sonuçlarımız, daha önce yapılan çalışmalarda tespit edilen HLA antijenleri ile uyumludur. Çalışmamız bölgemizdeki HLA çeşitliliğinin belirlenmesinde katkı sağlayacağını düşünmekteyiz. Çalışmamızda elde ettiğimiz veriler ve diğer ulusal verilerin toplanılması kemik iliği bağışçılarının seçiminde yardımcı olacaktır.

🔖

Cite This Article

DOĞAN, H., BALKAN, E., YAŞAR, E. (2022). The Diagnosis of Human Leukocyte Antigen Class I and Class Ii Allel In Eastern Anatolia Region. Van Tıp Dergisi, Cilt: 26 - Sayı: 2, 162–166. https://ajindex.com/articles/645973

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (12)

  1. Abbas KA, Andrew HL, Pillai S. Cellular and Molecular Immunology. Philadelphia: Saunders Elsevier: 2007
  2. Yalçın B. Major doku uygunluk kompleksi (MHC) molekülleri: genel özellikleri ve hastalıklarla ilişkisi.Turkderm 2013; 47(1): 12- 17
  3. Available from: http://hla.alleles.org/nomenclature/stats.html [Date last updated: December 2017] [Date last accessed:December 27 2017] 4. Andric Z, Popadic D, Jovanovic B, Jaglicic I, Bojic S, Simonovic R. HLA-A, -B, -C, -DRB1 and -DQB1 allele and haplotypefrequencies in the Serbian population. Hum Immunol 2014; 75: 218-226
  4. Tiercy JM, Claas F. Impact of HLA diversity on donor selection in organ and stem cell transplantation. Hum Hered 2013; 76: 178- 186
  5. Soyöz M et al. Human Leukocyte Antigen Class I-II Allele Frequencies and Association Between Human Leukocyte Antigen Alleles and ABO Blood Group Antigensİnsan Lökosit Antijeni Sınıf I-II Alel Frekansları ve İnsan Lökosit Antijeni Alelleri veABO Kan Grup Antijenleri Arasındaki İlişki. J Immunol 2016; 4(1): 14-18
  6. Choukri F, Chakib A, Himmich H, Hue S et al.HLA class I polymorphism in a Moroccan population from Casablanca. European Journal of Immunogenetics 2001; 29: 205-211
  7. Bardi MS, Jarduli LR, Jorge AJ, Camargo RB, Carneiro FP, Gelinski JR, et al. HLA-A, B and DRB1 allele and haplotype frequencies in volunteer bone marrow donors from the north of Parana State.ev Bras Hematol Hemoter 2012;34(1): 25-30
  8. Chen S, Hong W, Shao H, Fu Y, Liu X, Chen D et al. Allelic distribution of HLA class I genes in the Tibetan ethnic population of China. nt J Immunogenet 2006; 33(6): 439- 445
  9. Patıroğlu T, Işık N, Öter H. Kayseri Yöresinde Doku Antijenleri (HLA). Official Journal of the Turkish Nephrology Assosiation 1993; 3: 137-138
  10. Pala FS et al. Evaluation of Frequencies of HLA-A, B and DR in Thracian Population andExamination of its Relationship With Balkan Populations. Trakya Univ Tip Fak Derg 2008; 25(3): 189-195
  11. Erikoğlu M, Büyükdoğan M, Cora T. The Relationship Between.HLA Antigens and Blood Groups. European Journal of General.Medicine 2011; 8: 65-68
  12. Kayhan B, Kurtoglu EL, Taskapan H, et al.HLA-A, -B, -DRB1 allele and haplotype frequencies andcomparison with blood group antigens in dialysis patients in th eEast Anatolia region of Turkey.Transplant Proc 2013; 45: 2123-2128.