Journals / Van Tıp Dergisi / 2020 / Cilt: 27 - Sayı: 1

Ferritin and Transferrin Saturation Index Levels in Children with Attention Deficit Hyperactivity Disorder

Dikkat Eksikliği Hiperaktivite Bozukluğu Bulunan Çocuklarda Ferritin ve Transferrin Saturasyon Indeksi Düzeyleri

Pages
17–21
Publication Date
2022-11-06
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

The necessity ofevaluating iron parameters in ADHD cases has beenunderstood once again.

📌 3 Key Takeaways

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Objective & Hypothesis:Introduction: Attention deficit hyperactivity disorder(ADHD) is one of the common childhood psychiatricdisorders and is believed to be caused by genetic andenvironmental factors.
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Key Findings & Data:In our study, weaimed to investigate the correlation of serum ferritin andtransferrin saturation index (TSI) with ADHD subtypes andConners’ Teacher Rating Scale (CTRS) scores.Material and Methods: This retrospective study included131 boys and 16 girls between 7 and 16 years of age who werediagnosed with ADHD in accordance with DSM-IV TRdiagnostic criteria.
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Conclusion & Impact:The necessity ofevaluating iron parameters in ADHD cases has beenunderstood once again.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Introduction: Attention deficit hyperactivity disorder(ADHD) is one of the common childhood psychiatricdisorders and is believed to be caused by genetic andenvironmental factors. Various studies have reported thatbody iron levels and ADHD are correlated. In our study, weaimed to investigate the correlation of serum ferritin andtransferrin saturation index (TSI) with ADHD subtypes andConners’ Teacher Rating Scale (CTRS) scores.Material and Methods: This retrospective study included131 boys and 16 girls between 7 and 16 years of age who werediagnosed with ADHD in accordance with DSM-IV TRdiagnostic criteria. The data on serum iron, total iron-bindingcapacity, ferritin, and CTRS scores were obtained from thepatients’ hospital files. Statistical analyses were then done onthese data.Results: The mean serum ferritin level was 27.1 ± 15.6ng/mL, and the mean TSI level was 18.1 ± 9.1%. The meanserum ferritin level of those diagnosed with combined typeADHD (25.78 ± 12.90 ng/mL), in accordance with DSM-IVTR criteria, was lower than those diagnosed withpredominantly inattentive type (32.75 ± 23.54 ng/mL) (p =0.034). However, there was no difference in serum TSI values(p = 0.835).Conclusions: In the present study, serum ferritin levels werelower in patients with ADHD than in patients with attentiondeficit predominant type, and the relationship between ironparameters and ADHD was demonstrated. The necessity ofevaluating iron parameters in ADHD cases has beenunderstood once again.

Özet

Amaç: Dikkat Eksikliği Hiperaktivite Bozukluğu (DEHB) genetik ve çevresel faktörlerin neden olduğu düşünülen, çocukluk çağının sık görülen psikiyatrik bozukluklarından biridir. Vücut demiri ile DEHB’nin ilişkili olabileceği çeşitli çalışmalarda bildirilmiştir. Çalışmamızda DEHB tanısı alan çocuklarda, serum ferritin ve transferin saturasyon indeksi (TSI) ile DEHB alt tipleri ve Conners Öğretmen Derecelendirme Ölçeği (CÖDÖ) arasındaki ilişkinin incelenmesi amaçlanmıştır. Materyal ve Metod: Bu retrospektif çalışmaya DSM IV TR tanı kriterlerine göre DEHB tanısı alan, yaşları 7-16 arasında değişen 131 erkek ve 16 kız hasta alındı. Hastaların dosya bilgilerinden serum demir, total demir bağlama kapasitesi, ferritin ve CÖDÖ değerlerine ulaşıldı, istatistiksel değerlendirmeler yapıldı. Bulgular: Olgularımızın ortalama serum ferritin düzeyi 27.1±15.6 ng/mL ve TSI düzeyi ise % 18.1±9.1 olarak saptandı. DSM IV TR kriterlerine göre bileşik tip DEHB tanısı alanlarda ortalama serum ferritin düzeyi,( 25,78 ± 12,90 ng/mL) dikkat eksikliği baskın tipe (32,75 ± 23,54 ng/mL) göre daha düşük olarak saptanırken (p=0,034); serum TSI değerleri arasında herhangi bir farklılık yoktu (p=0,835). Sonuç: Bileşik tip DEHB olgularında serum ferritin düzeyinin, dikkat eksikliği baskın tip tanısı almış olanlara göre daha düşük olduğunun saptandığı çalışmamızda demir parametreleri ile DEHB ilişkisi ortaya konmuştur. DEHB’li olgularda demir parametrelerinin değerlendirilmesinin gerekliliği bir kez daha anlaşılmıştır.

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Cite This Article

TANER, H. A., ÇETİN, F. H., SAL, E., IŞIK, Y., ŞENER, Ş., GÜRSEL, T. (2022). Ferritin and Transferrin Saturation Index Levels in Children with Attention Deficit Hyperactivity Disorder. Van Tıp Dergisi, Cilt: 27 - Sayı: 1, 17–21. https://ajindex.com/articles/645956

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