ACK1/TNK2 Tyrosine Kinase Overexpression Role in Gastric Cancer

Objective & Hypothesis:ACK1 or TNK2 integrate signals from ligand active receptor tyrosine kinases, which are exogenous oncogenic nonreceptor tyrosinekinases, to modulate intracellular signaling cascades 1.

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Key Findings & Data:Several studies have revealed that ACK1/TNK2 is upregulated in variouscancers and promotes tumor progression.

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Conclusion & Impact:We identified overexpression of the TNK2 in gastric cancer is correlated with good prognosis.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Abstract

ACK1 or TNK2 integrate signals from ligand active receptor tyrosine kinases, which are exogenous oncogenic nonreceptor tyrosinekinases, to modulate intracellular signaling cascades 1. Several studies have revealed that ACK1/TNK2 is upregulated in variouscancers and promotes tumor progression. This study aimed to determine the prognostic role TNK2 overexpression in gastric cancer.Presence of TNK2 overexpression in pathology blocks of patients with non-metastatic operated gastric cancer was used as prognostic marker and survival was investigated. The pathology samples of 129 patients were studied. Mean survival times (64.2 months) ofthe gastric cancer patients with TNK2 overexpression were significantly longer than those without overexpression (27.1 months) (p=0.00). Median follow-up was 39 months. TNK2 overexpression rate was 75% in stage 1-2, 56% in stage 3 (p= 0.027). The positiveeffect of node negativity, ECOG performance status of 0-1 and TNK2 overexpression on survival in gastric cancer was also shown bymultivariate analysis. We identified overexpression of the TNK2 in gastric cancer is correlated with good prognosis.

Özet

ACK1/TNK2, vücutta yaygın olarak exprese edilen onkojenik non reseptör tirozin kinazdır. Ligant ile aktive edilen reseptör tirozin kinazlardan gelen sinyalleri intraselüler sinyal kaskadını düzenlemek için bütünleştirir. Yapılan çalışmalarda ACK1/TNK2’nin birçok kanserde upregüle olduğu gösterilmiştir. Bu çalışmada gastrik kanserde TNK2 ekspresyonunun prognostik rolünü belirlemeyi amaçladık. TNK2 overexpresyonu prognostik belirteç olarak kullanıldı, opere olan lokal evre mide kanserinde sağkalıma etkisi araştırıldı. TNK2 overexpresyonu olan mide kanserli hastaların ortalama sağkalım süresi (64.2 ay) overexpresyon olmayanlara göre (27.1 ay) anlamlı olarak daha uzundu (p= 0.000). Medyan takip süresi 39 ay idi. TNK2 overexpresyonu evre 1-2’de %75, evre 3’de %56 oranında görüldü (p= 0.027). Mide kanserinde nod negatifliği, ECOG performans statusun 0-1 olması ve TNK2 overexpresyonun olmasının sağkalıma pozitif etkisi multivariate analiz ile de gösterildi. TNK2 overexpresyonu erken evrede daha fazla oranda görülür ve opere mide kanserinde iyi prognozla ilişkilidir.

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Cite This Article

ERCELEP, Ö., KESER, S., OZCELIK, M., BASAR, M. (2022). ACK1/TNK2 Tyrosine Kinase Overexpression Role in Gastric Cancer. Uluslararası Hematoloji-Onkoloji Dergisi, Cilt: 29 - Sayı: 2, 55–60. https://ajindex.com/articles/644755

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