Assessing the therapeutic effect of resveratrol in heart failure following blunt chest trauma and the potential role of endocan as a biomarker of inflammation using rats
Sıçanlarda künt göğüs travma sonrası oluşan kalp hasarı üzerine resveratrolün tedavi edici etkisinin ve endokanın enflamasyonda bir biyobelirteç olarak potansiyel rolünün değerlendirilmesi
The mean endocan values of the differed between thegroups (p
📌 3 Key Takeaways
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Objective & Hypothesis:BACKGROUND: The present study investigated the therapeutic effect of resveratrol on cardiac injury resulting from blunt chesttrauma and the utility of endocan as a biomarker of the inflammation process using rats.METHODS: The rats were randomly divided into the following four groups (n=7 in each group): a control group (no treatment ortrauma); trauma-induced group (trauma group); resveratrol group (resveratrol 0.3 mg/kg administered via the intraperitoneal [i.p.] routegroup); and resveratrol + trauma group (resveratrol 0.3 mg/kg administered via the i.p. route 1 hour prior to the induction of trauma).RESULTS: The immunoreactivity of tumor necrosis factor-α and inducible nitric oxide synthase in the trauma group was increased,whereas the reaction intensity in resveratrol + trauma group was deceased.
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Key Findings & Data:BACKGROUND: The present study investigated the therapeutic effect of resveratrol on cardiac injury resulting from blunt chesttrauma and the utility of endocan as a biomarker of the inflammation process using rats.METHODS: The rats were randomly divided into the following four groups (n=7 in each group): a control group (no treatment ortrauma); trauma-induced group (trauma group); resveratrol group (resveratrol 0.3 mg/kg administered via the intraperitoneal [i.p.] routegroup); and resveratrol + trauma group (resveratrol 0.3 mg/kg administered via the i.p. route 1 hour prior to the induction of trauma).RESULTS: The immunoreactivity of tumor necrosis factor-α and inducible nitric oxide synthase in the trauma group was increased,whereas the reaction intensity in resveratrol + trauma group was deceased.
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Conclusion & Impact:The mean endocan values of the differed between thegroups (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Abstract
BACKGROUND: The present study investigated the therapeutic effect of resveratrol on cardiac injury resulting from blunt chesttrauma and the utility of endocan as a biomarker of the inflammation process using rats.METHODS: The rats were randomly divided into the following four groups (n=7 in each group): a control group (no treatment ortrauma); trauma-induced group (trauma group); resveratrol group (resveratrol 0.3 mg/kg administered via the intraperitoneal [i.p.] routegroup); and resveratrol + trauma group (resveratrol 0.3 mg/kg administered via the i.p. route 1 hour prior to the induction of trauma).RESULTS: The immunoreactivity of tumor necrosis factor-α and inducible nitric oxide synthase in the trauma group was increased,whereas the reaction intensity in resveratrol + trauma group was deceased. The mean endocan values of the differed between thegroups (p
Özet
AMAÇ: Bu çalışma, sıçanlarda künt göğüs travmasına bağlı gelişen kardiyak hasar üzerine resveratrolün terapötik etkisini ve endokanın enflamasyon sürecinde bir biyobelirteç olarak kullanılmasını araştırmıştır. GEREÇ VE YÖNTEM: Sıçanlar randomize olarak aşağıdaki dört gruba ayrıldı (her grupta, n=7): bir kontrol grubu (tedavi veya travma olmadan); travma uygulanan grup (travma grubu); resveratrol grubu (resveratrol, [0.3 mg/kg] intraperitoneal [i.p.] yol grubu yoluyla uygulandı); ve resveratrol + travma grubu (travmanın uygulanmasından 1 saat önce i.p. yolla resveratrol [0.3 mg/kg] verilen). BULGULAR: Travma grubundaki tümör nekroz faktörü-α ve indüklenebilir nitrik oksit sentazın immünreaktivitesi artarken, resveratrol + travma grubundaki reaksiyon şiddeti azaldı. Grupların ortalama endokan değerleri farklıydı (p
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Cite This Article
Tütüncü, Ş., Torun, A. C. (2022). Assessing the therapeutic effect of resveratrol in heart failure following blunt chest trauma and the potential role of endocan as a biomarker of inflammation using rats. Ulusal Travma ve Acil Cerrahi Dergisi, Cilt: 25 - Sayı: 4, 343–349. https://ajindex.com/articles/644281
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