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Journals / Ulusal Travma ve Acil Cerrahi Dergisi / 2020 / Cilt: 26 - Sayı: 5

The efficacy of curcumin on PDGF expression and NF-kappa B pathway: TNBS-induced colitis

Kurkumin’in PDGF ekspresyonu ve NF-kappa B üzerindeki etkisi: TNBS kolit modeli

Güven ÖZKAYA
Gülçin ERCAN
Yüksel ALTINEL
Şenay YALÇIN
Erkan YAVUZ
Candaş ERÇETİN
Osman BİLGİN GÜLÇİÇEK
Atilla ÇELİK
Hafize UZUN
Pages
663–670
Publication Date
2022-11-06
DOI
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At the end of the seven day, the blood and intestinal tissue samples were obtainedfor histopathological examination and for MPO, MDA, NO, PDGF, IL-6, TNF-alpha, NF-kappaB.RESULTS: The macroscopic damage score was significantly higher in curcumin oral, corn oil oral and saline groups when compared tothe sham group (p

📌 3 Key Takeaways

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Objective & Hypothesis:BACKGROUND: Curcumin is an antioxidant and anti-inflammatory molecule known to be a potent inhibitor of nuclear factor kappaB (NF-kappa B).
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Key Findings & Data:In this study, we aimed to investigate the therapeutic effects of curcumin on colitis induced by a 2,4,6-trinitrobenzenesulfonic acid (TNBS).METHODS: After the induction of colitis under anesthesia, 42 rats were divided into six groups as follows; the curcumin oral group,curcumin (20 mg/kg); the corn oil oral group, corn oil (20 mg/kg) using gastric gavage, the curcumin rectal group, curcumin; the cornoil rectal group, corn oil; the control group, 1 mL saline solution (0.9% NaCl) were administered using the rectal route.
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Conclusion & Impact:At the end of the seven day, the blood and intestinal tissue samples were obtainedfor histopathological examination and for MPO, MDA, NO, PDGF, IL-6, TNF-alpha, NF-kappaB.RESULTS: The macroscopic damage score was significantly higher in curcumin oral, corn oil oral and saline groups when compared tothe sham group (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

BACKGROUND: Curcumin is an antioxidant and anti-inflammatory molecule known to be a potent inhibitor of nuclear factor kappaB (NF-kappa B). In this study, we aimed to investigate the therapeutic effects of curcumin on colitis induced by a 2,4,6-trinitrobenzenesulfonic acid (TNBS).METHODS: After the induction of colitis under anesthesia, 42 rats were divided into six groups as follows; the curcumin oral group,curcumin (20 mg/kg); the corn oil oral group, corn oil (20 mg/kg) using gastric gavage, the curcumin rectal group, curcumin; the cornoil rectal group, corn oil; the control group, 1 mL saline solution (0.9% NaCl) were administered using the rectal route. In the shamgroup, only rectal catheterization was performed. At the end of the seven day, the blood and intestinal tissue samples were obtainedfor histopathological examination and for MPO, MDA, NO, PDGF, IL-6, TNF-alpha, NF-kappaB.RESULTS: The macroscopic damage score was significantly higher in curcumin oral, corn oil oral and saline groups when compared tothe sham group (p

Özet

AMAÇ: Kurkumin, nükleer faktör kappa B’nin (NF-kappa B) güçlü bir inhibitörü olduğu bilinen antioksidan ve antienflamatuvar bir moleküldür. Kurkumin’in 2,4,6-trinitrobenzen sülfonik asit (TNBS) ile indüklenen kolit modeli üzerindeki etkisini araştırmayı amaçladık. GEREÇ VE YÖNTEM: Anestezi altında kolit indüksiyonundan sonra, 42 sıçan altı gruba ayrıldı; kurkumin oral grup, kurkumin (20 mg/kg); mısır yağı oral grubu, mısır yağı (20 mg/kg) mide gavajı yoluyla, kurkumin rektal grubu, kurkumin; mısır yağı rektal grubu, mısır yağı. Kontrol grubuna 1 mL salin solüsyonu (%0.9 NaCl) rektal yolla uygulandı. Sham grubunda sadece rektal kateterizasyon yapıldı. Yedi gün sonunda, histopatolojik inceleme ve MPO, MDA, NO, PDGF, IL-6, TNF-alfa, NF-kappa B için kan ve bağırsak doku örnekleri alındı. BULGULAR: Makroskobik hasar skoru, kurkumin oral, mısır yağı oral ve salin gruplarında sham grubuna göre anlamlı olarak yüksek bulundu (p

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Cite This Article

ÖZKAYA, G., ERCAN, G., ALTINEL, Y., YALÇIN, Ş., YAVUZ, E., ERÇETİN, C., GÜLÇİÇEK, O. B., ÇELİK, A., UZUN, H. (2022). The efficacy of curcumin on PDGF expression and NF-kappa B pathway: TNBS-induced colitis. Ulusal Travma ve Acil Cerrahi Dergisi, Cilt: 26 - Sayı: 5, 663–670. https://ajindex.com/articles/644191

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