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Journals / Ulusal Travma ve Acil Cerrahi Dergisi / 2022 / Cilt: 28 - Sayı: 8

Loop nerve graft prefabrication for peripheral nerve defect reconstruction

Sinan Öksüz
Fikret Eren
Ceyhun Cesur
Merve Açıkel Elmas
Serap Şirvancı
Pages
1043–1051
Publication Date
2022-11-06
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Group 3 (−33.64±6.4) had a statistical difference compared to other groups (p0.05), whereas both groups had a statistical difference compared to Group 3 (10.44±1.96 mV/1.51±0.15 ms) (p0.05), whereas both groups had significantly poor axon counts compared to Group 2 (2531±91.18) (p

📌 3 Key Takeaways

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Objective & Hypothesis:BACKGROUND: Delayed autologous nerve graft reconstruction is inevitable in devastating injuries.
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Key Findings & Data:METHODS: Twenty-four Sprague-Dawley rats were allocated into three groups. 1.5 cm long peroneal nerve segment was excised, reversed in orientation, and used as autologous nerve graft.
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Conclusion & Impact:Group 3 (−33.64±6.4) had a statistical difference compared to other groups (p0.05), whereas both groups had a statistical difference compared to Group 3 (10.44±1.96 mV/1.51±0.15 ms) (p0.05), whereas both groups had significantly poor axon counts compared to Group 2 (2531±91.18) (p
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

BACKGROUND: Delayed autologous nerve graft reconstruction is inevitable in devastating injuries. Delayed or prolonged repair time has deleterious effects on nerve grafts. We aimed improving and accelerating nerve graft reconstruction process in a rat long nerve defect model with loop nerve graft prefabrication particularly to utilize for injuries with tissue loss. METHODS: Twenty-four Sprague-Dawley rats were allocated into three groups. 1.5 cm long peroneal nerve segment was excised, reversed in orientation, and used as autologous nerve graft. In conventional interpositional nerve graft group (Group 1), nerve defects were repaired in single-stage. In loop nerve graft prefabrication group (Group 2), grafts were sutured end-to-end (ETE) to the proximal peroneal nerve stumps. Distal ends of the grafts were sutured end-to-side to the peroneal nerve stumps 5 mm proximal to the ETE repair sites in first stage. In second stage, distal ends of the prefabricated grafts were transposed and sutured to distal nerve stumps. In staged conventional interpositional nerve graft group (Group 3), grafts were sutured ETE to proximal peroneal nerve stumps in first stage. Distal ends of the grafts and nerve stumps were tacked to the surrounding muscles until the final repair in second stage. Follow- up period was 4 weeks for each stage in Groups 2 and 3, and 8 weeks for Group 1. Peroneal function index (PFI), electrophysiology, and histological assessments were conducted after 8 weeks. P0.05). Group 3 (−33.64±6.4) had a statistical difference compared to other groups (p0.05), whereas both groups had a statistical difference compared to Group 3 (10.44±1.96 mV/1.51±0.15 ms) (p0.05), whereas both groups had significantly poor axon counts compared to Group 2 (2531±91.18) (p

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Cite This Article

Öksüz, S., Eren, F., Cesur, C., Elmas, M. A., Şirvancı, S. (2022). Loop nerve graft prefabrication for peripheral nerve defect reconstruction. Ulusal Travma ve Acil Cerrahi Dergisi, Cilt: 28 - Sayı: 8, 1043–1051. https://ajindex.com/articles/644047

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