Journals / Türk Yoğun Bakım Dergisi / 2021 / Cilt: 19 - Sayı: 2

Neuroleptic Malignant Syndrome Requires Intensive Care Monitoring: A Review with Three Cases

Yoğun Bakımda Takibi Gerektiren Üç Nöroleptik Malign Sendrom Olgusu ve Literatür Taraması

Pages
94–97
Publication Date
2022-11-06
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Herein, we report three cases of NMS and discuss their possible aetiology with reference to the existing literature.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Neuroleptic malignant syndrome (NMS) is a rare, idiosyncratic and potentially fatal side effect of antipsychotics.
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Key Findings & Data:The syndrome is characterised by hyperthermia (fever), muscle rigidity, autonomic disturbances and alterations of mental state.
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Conclusion & Impact:Herein, we report three cases of NMS and discuss their possible aetiology with reference to the existing literature.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Neuroleptic malignant syndrome (NMS) is a rare, idiosyncratic and potentially fatal side effect of antipsychotics. The syndrome is characterised by hyperthermia (fever), muscle rigidity, autonomic disturbances and alterations of mental state. Psychotropic medications, such as typical and atypical antipsychotics, certain dopamine receptor-blocking drugs used in the treatment of nausea and gastroparesis (e.g. promethazine, metoclopramide and prochlorperazine) and antidepressants, such as amoxapine, have all been implicated in the aetiology of NMS. Herein, we report three cases of NMS and discuss their possible aetiology with reference to the existing literature.

Özet

Nöroleptik malign sendrom (NMS), antipsikotik ilaçların nadir görülen, idiyosenkratik, potansiyel olarak ölümcül bir yan etkisidir. Sendrom, hipertermi (ateş), rijidite, otonomik bozukluklar ve zihinsel değişiklikler ile karakterizedir. Tipik ve atipik antipsikotikler gibi psikotropik ilaçlar, bulantı ve gastroparezi tedavisinde kullanılan bazı dopamin reseptör antagonisti ilaçlar (örneğin; prometazin, metoklopramid, proklorperazin) ve amoksapin gibi antidepresanların tümü NMS etiyolojisinde yer almıştır. Bu olgu serisinde üç NMS olgusu bildirdik ve mevcut literatürler eşliğinde olası etiyolojileri tartışmayı amaçladık.

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Cite This Article

ŞEN, İ. A., SUNGURTEKİN, H., KILINÇ, M., ŞEN, C. (2022). Neuroleptic Malignant Syndrome Requires Intensive Care Monitoring: A Review with Three Cases. Türk Yoğun Bakım Dergisi, Cilt: 19 - Sayı: 2, 94–97. https://ajindex.com/articles/643418

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