Journals / Türk Yoğun Bakım Dergisi / 2022 / Cilt: 20 - Sayı: Ek 1

The Effect of Secondary Infections on Mortality in Patients with COVID-19 Associated Severe ARDS

COVİD-19 ile İlişkili Şiddetli ARDS Hastalarında Sekonder Enfeksiyonların Mortalite Üzerine Etkisi

Pages
62–70
Publication Date
2022-11-06
DOI
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In the group with secondary infections, a significant increase in lymphocyte and lactate levels was observed between the time of admission and time of sampling culture (p

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Objective & Hypothesis:Objective: In the beginning of the coronavirus disease-2019 (COVID-19) pandemic, secondary bacterial, fungal and viral infections have been reported in the intensive care unit (ICU), but there is limited experience with infections in critically ill patients over time.
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Key Findings & Data:The aim this study was to evaluate the characteristics of secondary infections related to ICU and their effects on mortality in COVID-19 patients.
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Conclusion & Impact:In the group with secondary infections, a significant increase in lymphocyte and lactate levels was observed between the time of admission and time of sampling culture (p
🔬Design:Research Article
📍Scope:2019 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: In the beginning of the coronavirus disease-2019 (COVID-19) pandemic, secondary bacterial, fungal and viral infections have been reported in the intensive care unit (ICU), but there is limited experience with infections in critically ill patients over time. The aim this study was to evaluate the characteristics of secondary infections related to ICU and their effects on mortality in COVID-19 patients. Materials and Methods: Our study was planned as a retrospective single-center case-control study involving 145 patients with severe severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pneumonia hospitalized in the ICU between March and June 2020. The epidemiological, clinical and microbiological characteristics and results of ICU-related infections were evaluated. Results: The mean age of the patients was 61.2 years and mean body mass index was 28 kg/m2. At least one comorbidity was found in 140 patients (96.6%). Seventy seven of (53.1%) the patients diagnosed with COVID-19 included in the study died. In addition to SARS-CoV-2, the isolation of different pathogens was observed in 62 (42.75%) patients’ samples. In the group with secondary infections, a significant increase in lymphocyte and lactate levels was observed between the time of admission and time of sampling culture (p

Özet

Amaç: Koronavirüs hastalığı-2019 (COVİD-19) pandemisinin ilk dönemlerinde yoğun bakım ünitesinde (YBÜ) takip edilen hastalarda bakteriyel, fungal ve viral kaynaklı daha az sekonder enfeksiyonlar olduğu bildirilmiştir. COVİD-19’lu kritik hastalarda bakteriyel enfeksiyon deneyimi sınırlıdır. Bu çalışmanın amacı, COVİD-19 hastalarında YBÜ kaynaklı sekonder enfeksiyonların özelliklerini ve mortalite üzerine olan etkilerini değerlendirmektir. Gereç ve Yöntem: Çalışmamız, Mart ve Haziran 2020 tarihleri arasında YBÜ’de yatan ve şiddetli akut solunum yolu yetersizliği sendromu (SARS-CoV-2) pnömonisi olan 145 hastayı içeren tek merkezli retrospektif bir olgu-kontrol çalışması olarak planlandı. YBÜ kaynaklı enfeksiyonların epidemiyolojik, klinik ve mikrobiyolojik özellikleri ve sonuçları değerlendirildi. Bulgular: Hastaların ortalama yaşı 61,2 yıl ve vücut kitle indeksleri 28 kg/m2 olarak saptandı. Yüz kırk (%96,6) hastada en az bir komorbidite olduğu belirlendi. Çalışmadaki tüm COVİD-19 tanılı hastalardan 77’sinde (%53,1) ölüm gerçekleşti. Altmış iki (%42,75) hastada SARS-CoV-2’ye ek olarak farklı patojen üremesi saptandı. Kültürde ek mikroorganizma üreyen grupta ilk ölçülen lenfosit ve laktat düzeyleri ile kültür alındıktan sonra yapılan ölçümler arasında anlamlı bir artış belirlendi (p

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Cite This Article

ŞEKER, Y. T., YEŞİLBAĞ, Z., GÜNGÖRDÜ, E., ÇUKUROVA, Z. (2022). The Effect of Secondary Infections on Mortality in Patients with COVID-19 Associated Severe ARDS. Türk Yoğun Bakım Dergisi, Cilt: 20 - Sayı: Ek 1, 62–70. https://ajindex.com/articles/643374

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