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Journals / Türk Pediatri Arşivi / 2002 / Cilt: 30 - Sayı: 5

Do antihistamines reduce side effects of rapid vancomycin infusion? (Case report)

Hızlı vankomisin infüzyonunun yan etkilerini antihistaminikler azaltır mı?

Yıldıray TABEL
Emine ÇAPAR
Leyla İYİLİKÇİ
Atalay ARKAN
Pages
236–238
Publication Date
2022-11-05
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Antihistamines administered before vancomycin infusion may attenuate adverse effects of vancomycin due to histamine release.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:In this case report 8 months old male infant in whom V-P shunt surgery was planned for hydrocephalus is presented.
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Key Findings & Data:Vancomycin 240 mg was administered accidentally intravenously in 1-2 minutes during the operation.
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Conclusion & Impact:Antihistamines administered before vancomycin infusion may attenuate adverse effects of vancomycin due to histamine release.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

In this case report 8 months old male infant in whom V-P shunt surgery was planned for hydrocephalus is presented. Vancomycin 240 mg was administered accidentally intravenously in 1-2 minutes during the operation. Probably due to diphenhydramine (1 mg/kg) administered before vancomycin infusion no symptoms of 'Red Man Syndrome' as hypotension and maculopapular skin rash occurred. Antihistamines administered before vancomycin infusion may attenuate adverse effects of vancomycin due to histamine release.

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Cite This Article

TABEL, Y., ÇAPAR, E., İYİLİKÇİ, L., ARKAN, A. (2022). Do antihistamines reduce side effects of rapid vancomycin infusion? (Case report). Türk Pediatri Arşivi, Cilt: 30 - Sayı: 5, 236–238. https://ajindex.com/articles/641754

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References (10)

  1. Vickers MD, Morgan M, Spencer PSJ: Drugs in Anaesthetic Practice. 7th. Ed., Butterworth-Heinemann, London, 1991; 475
  2. Rumack BH (ed): Poinsindex Information System, Denver, Colorado: Micromedex Inc, 2000
  3. Wallece Mr, Mascola JR, Oldfield EC: Red Man Syndrome: incidence, etiology and prophylaxis J Infect Dis 1991; 164(6):1180-5
  4. Renz CH, Turn JD, Finn HA: Oral antihistamines reduce the side effects from rapid vancomycin infusion. Anesth Analg 1998; 87:681-91
  5. Luskin AT, Luskin SS: Anaphylaxis and anaphylactid reactions: Diagnosis and management Am J Ther 1996; 3(7):515-20
  6. Polk RE, Healy DP, Schwartz LB: Vancomycin and the red-man syndrome: Pharmacodynamics of histamine release. J Infect Dis 1988; 157: 502-7
  7. Erşahin Y: Beyin omurilik sıvısı şant enfeksiyonları. Türk Nöroşirürji Dergisi 1999; 9:12-20
  8. Seay RE, Brundage RC, Jensen PD: Population pharmacokinetics of vancomycin in neonates. Clin Pharmacol Ther 1994; 56:169-75
  9. Renz C, Lynch J, Thurn J, Moss J: Histamine release during rapid vancomycin administration Inflamm Res 1998; 47(Suppl 1):69-70
  10. Sahai J, Healy DP, Garris R, Berry A, Polk PE: Influence of antihistamine pretreatment on vancomycin-induced red man syndrome. J Infect Dis 1989; 160(5):876-81.