Journals / Türk Pediatri Arşivi / 2002 / Cilt: 30 - Sayı: 9

Our experience with critically ill hematologic malignancies

Hematolojik kanser hastalarında yoğun bakım deneyimlerimiz

Pages
413–418
Publication Date
2022-11-05
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Overall mortality rate was found 74 % and most of the patients (48 %) were died due to septic shock and multiple organ failure.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Patients with hematologic malignancies can often develop complications which should be treated in intensive care units.
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Key Findings & Data:In our study, we aimed to evaluate the severity of underlying disease and acute illness, the diagnosis of intensive care unit admission, treatment characteristics, mortality rate and prognostic indicators in patients with hematologic malignancies.
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Conclusion & Impact:Overall mortality rate was found 74 % and most of the patients (48 %) were died due to septic shock and multiple organ failure.
🔬Design:Research Article
📍Scope:2001 Verileri
⚙️Variables:Domain Parameters

Abstract

Patients with hematologic malignancies can often develop complications which should be treated in intensive care units. In our study, we aimed to evaluate the severity of underlying disease and acute illness, the diagnosis of intensive care unit admission, treatment characteristics, mortality rate and prognostic indicators in patients with hematologic malignancies. We examined 42 patients with hematologic malignancies who admitted to the I.V. Istanbul Medical Faculty Anaesthesiology Department Intensive Care Unit between 1991-2001. The main admission diagnosis of the patients was acute respiratory failure mostly due to pneumonia (69 %). Mechanical ventilation Was performed to all of the patients. The duration of mechanical ventilation was found 11.04±9.4 days and intensive care unit stay was found 12.4+10.6 days. Overall mortality rate was found 74 % and most of the patients (48 %) were died due to septic shock and multiple organ failure. In this study, age, APACHE II and SOFA scores, leukocyte and thrombocyte counts, and duration of mechanical ventilation did not demonstrate any rela-tion with mortality rate. In our study population, the factor that influence the mortality was found to be the development of septic shock.

Özet

Hematolojik kanser hastalarında tedavi sırasında gelişen ve yoğun bakım takibi gerektiren komplikasyonlara sık olarak rastlanmaktadır. Bu retrospektif araştırmada reanimasyon ünitesinde izlenmiş olan hematolojik kanser hastalarınının yoğun bakıma alınma nedenleri, altta yatan hastalığın ağırlık derecesi, tedavi özellikleri, mortalite oranı ve prognozu etkileyen faktörler incelenmiştir. 1991-2001 yılları arasında ünitemizde tedavi görmüş toplam 42 hastanın % 69'unun yoğun bakıma alınma sebebinin pnömoniye bağlı akut solunum yetersizliği olduğu tespit edilmiştir. Hastaların tümüne mekanik ventilasyon uygulanmış, mekanik ventilasyon süresi 11.04±9.4 gün, yoğun bakım kalış süresi ise 12.4±10.6 gün bulunmuştur, incelediğimiz popülasyonun mortalite oranı % 74'dür. Ölüm nedenleri incelendiğinde 15 hastanın (%48) septik şok ve çoğul organ yetersizliği tablosunda kaybedildiği görülmüştür. Çalışmamızda hastaların yaşı, giriş APACHE II, SOFA skorları, lökosit ve tromıbosit değerleri ve mekanik ventilasyon süresinin mortalite ile ilişkisi gösterilememiştir, incelediğimiz hasta grubunda septik şok gelişmesi mortalileyi artıran tek faktör olarak bulunmuştur.

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Cite This Article

TUĞRUL, S., ESEN, F., ÇAKAR, N., AKPİR, K., TELCİ, L., AKINCI, Ö., ÖZCAN, E. P. (2022). Our experience with critically ill hematologic malignancies. Türk Pediatri Arşivi, Cilt: 30 - Sayı: 9, 413–418. https://ajindex.com/articles/641728

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References (15)

  1. Armitage JO: Bone marrow transplantation. N Engl J Med 1994; 330:827-38
  2. Chan CK, Hyland RH, Hutcheon MA: Pulmonary complica¬ tions following bone marrow transplantation. Clin Chest Med 1990; 11:323-32
  3. Krowka MJ, Rosenow EC, Hoagland HC: Pulmonary com¬ plications following bone marrow transplantation. Chest 1985; 87:237-46
  4. Gruson D, Hubert G, Vargas F, et al: Severe non-infectous lung injury in early phase of bone marrow transplantation. Intensive Care Med 1998; 24:536-41
  5. Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, Hudson L, Lamy M, Le Gall JR, Morris A, Spragg R and the Consensus Committee. The American-European Consensus Conference on ARDS. Definition, mechanism, relevant outcomes and clinical trial coordination. Am J Respir Crit Care Med 1994; 149: 818-24
  6. Lloyd-Thomas AR, Wright I, Lister TA, Hinds CJ: Prognosis of patients receiving intensive care for lifethreatening medical complications of haematological malignancy. Br Med J 1988; 296:1025-9
  7. Estopa R, Torres Marti A, Kastanos N, et al: Acute respira¬ tory failure in severe hematologic disorders. Crit Care Med 1984; 12:26-8
  8. Schuster DP, Marion JM: Precedents for meaningful recov¬ ery during treatment in a medical intensive care unit. Outcome in patients with haematological malignancy. Am J Med 1983; 75:402-8
  9. Price KJ, Thall PF, Kish SK> et al: Prognostic indicators for blood and bone marrow transplant patients admitted to an inten¬ sive care unit. Am J Respir Crit Care Med 1998; 158:876-84
  10. Hubert G, (îrusotı D, Vargas F, et al: Non-invasive conti- nous positive airway pressure in neutropenic patients with acute respiratory failure requiring intensive care Unit admission. Crit Care Med 2000; 28:3185-9
  11. Todd K, Wiley F, Landow E, et al: Survival outcome among 54 intubated pediatric bone marrow transplant patients. Crit Care Med 1994; 22:171 -6
  12. Denardo S.J, Oye RK, Bellamy PE: Efficacy of intensive care for bone marrow transplant patients with respiratory failure. Crit Care Med 1989; 17:4-6
  13. Torricilla C, Cortes JL, Chamorro C, el MI: Prognostic assessment of the acute complications of bone marrow transplan¬ tation requiring intensive therapy. Intensive Care Med 1988;14:393-8
  14. Crawford SW, Petersen FB: Long-term survival from respi¬ ratory failure after bone marrow transplantation for malignancy. Am Rev Respir Dis 1992; 145:510-4
  15. Blot F, Guiguet M, Nitenberg G, et al: Prognostic factors for neutropenic patients in an intensive care un