SavedAdd your journal

Journals / Türk Pediatri Arşivi / 2005 / Cilt: 40 - Sayı: 4

Retinoblastoma: Results of Cerrahpaşa Medical Faculty

Cerrahpaşa Tıp Fakültesi retinoblastom deneyimi

Ömer UZEL
Gültekin KANER
Halit PAZARLI
İnci YILDIZ
Ferda ÖZKAN
Hilmi APAK
Aylin CANPOLAT
Alp ÖZKAN
Cuyan DEMİRKESEN
Tiraje CELKAN
Serap KARAMAN
Pages
299–303
Publication Date
2022-11-05
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The overall mean age at the time of diagnosis was 25 months; in unilateral cases, 29 months; and in bilateral cases, 16 months.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: In this study, we aim to describe the survival and clinical characteristics of 141 retinoblastoma cases treated at Cerrahpaşa Medical Faculty, University of Istanbul, between 1981 and 2004.
📊
Key Findings & Data:Material and Method: We retrospectively analyzed the clinical records of 141 children (177 eyes) diagnosed with retinoblastoma and treated between 1981-2004.
💡
Conclusion & Impact:The overall mean age at the time of diagnosis was 25 months; in unilateral cases, 29 months; and in bilateral cases, 16 months.
🔬Design:Research Article
📍Scope:2004 Verileri
⚙️Variables:Domain Parameters

Abstract

Aim: In this study, we aim to describe the survival and clinical characteristics of 141 retinoblastoma cases treated at Cerrahpaşa Medical Faculty, University of Istanbul, between 1981 and 2004. Material and Method: We retrospectively analyzed the clinical records of 141 children (177 eyes) diagnosed with retinoblastoma and treated between 1981-2004. The survival rates were calculated by Kaplan-Meier method. Results: One hundred and five (74.5%) cases were unilateral and 36 (25.5%)were bilateral. The overall mean age at the time of diagnosis was 25 months; in unilateral cases, 29 months; and in bilateral cases, 16 months. The most common presenting signs were leukocoria (116 cases,82%), strabismus (14 cases, 10%) and proptosis (11 cases, 8%). Conclusions: The three-year cumulative survival rate of the 141 patients was 89.69% (unilateral, 90.74%; bilateral 87.35% p=0.9371, p >0.05, log rank test).

Özet

Amaç: Bu çalışmada 1981- 2004 yılları arasında Cerrahpaşa Tıp Fakültesinde tedavi gören 141 retinoblastom hastasının klinik ve sağkalım özellikleri tanımlanmıştır. Gereç ve Yöntem: 1981-2004 yıllan arasında retinoblastom tanısı alan 141 çocuğun (177 göz) klinik kayıtlan geriye dönük olarak incelenmiştir. Hastalanmızın sağkalım sonuçları Kaplan-Meier yöntemine göre hesaplanmıştır. Bulgular: Olgulanmızın 105'i (%74,5) tek taraflı, 36'sı (%25,5) iki taraflı idi. Ortalama tanı yaşı 25 ay olup, tek taraflı olgular için 29 ay, iki taraflı olgular için ise 16 ay idi. Başlangıç bulgulan en sık lökokori (116 olgu, %82), şaşılık (14 olgu, %10) ve propitozis (11 olgu, %8) idi. Çıkarımlar: 141 olgumuzun üç yılhk toplam sağkalım değeri %89,69 (tek taraflı %90,74; iki taraflı %87, 35 p= 0,9371, p>0,05, log rank testi).

🔖

Cite This Article

UZEL, Ö., KANER, G., PAZARLI, H., YILDIZ, İ., ÖZKAN, F., APAK, H., CANPOLAT, A., ÖZKAN, A., DEMİRKESEN, C., CELKAN, T., KARAMAN, S. (2022). Retinoblastoma: Results of Cerrahpaşa Medical Faculty. Türk Pediatri Arşivi, Cilt: 40 - Sayı: 4, 299–303. https://ajindex.com/articles/641701

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (16)

  1. Desjardins L, Doz F, Schlinger P, et al. Le retinoblastome. Ann Pediatr 1996; 43: 359-71
  2. Moll AC, Imhof SM, Bouter LX, et al. Second primary tumors in patients with hereditary retinoblastoma: a register-based follow-up study 1945-1994. Int J Cancer 1996; 67: 515-9
  3. Doz F, Brisse H, Lyonnet SD, Sastre X, Zucker JM, Desjardins L. Retinoblastoma. In: Pinkerton R, Plowman PN, Pieters R (eds). Pediatric Oncology. 3th ed. London: Arnold 2004; 323-39, 4. Tamboli A,Podgor MJ,Horm JW. The incidence of retinoblastoma in the United States: 1974 through 1985. Arch Ophthalmol 1990; 108:128-32
  4. Ajaiyeoba LA, Akang EE, Campbell OB, Olurin IO, Aghadiuno PU. Retinoblastomas in Ibadan: Treatment and prognosis. West AfrJMed 1993; 12: 223-7
  5. Saw SM, Tan N, Lee SB, Au Eong KG, Chia KS. Incidence and survival characteristics of retinoblastoma in Singapore from 1968-1995. J Pediatr Ophthalmol Strabismus 2000; 37:87-93
  6. Moll AC, Kuik DJ, Bouter LM, et al. Incidence and survival of retinoblastoma in the Netherlands: a register based study 1862-1995. Br J Ophthalmoi 1997; 81: 559-62
  7. Kao LY, Su WW, Lin YW. Retinoblastoma in Taiwan: survival and clinical characteristics 1978-2000. Jpn J Ophthmol 2002; 46: 577-80
  8. Leal-Leal C, Flores-Rojo M, Medina-Sanson A, et al. Amulticentre report from the Mexican Retinoblastoma Group. Br J Ophthalmoi 2004,88:1074-7
  9. Chantada G, Fandino A, Manzitti J, et al. Late diagnosis of retinoblastoma in a developing country. Arch Dis Child 1999; 80:171-4
  10. Sanders BM, Draper GJ, Kingston JE. Retinoblastoma in Great Britain 1969-80: incidence, treatment, and survival. BrJ Ophthalmoi 1988; 72: 576-83
  11. Abramson DH. Retinoblastoma 1990: diagnosis, treatment and implications. Pediatr Ann 1990; 19: 388-95
  12. Lennox E, Draper G, Sanders B. Retinoblastoma: a study of natural history and prognosis of 268 cases. BMJ 1975; 3:731-4
  13. Abramson DH, Frank CM, Susman M, Whalen MP, Dunkel IJ, Boyd NW. Presenting signs of retinoblastoma. J Pediatr 1998; 132: 505-8
  14. Schouten-VanMAY,MollAC,Imhof SM, VeermanAJ. Overview: chemotherapy for retinoblastoma: an expanding area of clinical research. Med Pediatr Oncol 2002; 38: 428-38
  15. Shields JA, Shields CL, Sivalingam V. Decressing frequency of enucleation in patients with retinoblastoma. Am J Ophthalmoi 1989; 108: 185-8
  16. Epstein JA, Shields CL, Shields JA. Trends in the management of retinoblastoma: evaluation of 1196 consecutive eyes during 1974-2001. J Pediatr Ophthalmoi Strabi