Journals / Türk Pediatri Arşivi / 2009 / Cilt: 44 - Sayı: 3

Fetal valproate syndrome

Fetal valproat sendromu

Pages
106–108
Publication Date
2022-11-05
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

A case with facial features including epicanthal folds, depressed nasal bridge, hypertelorism, retrognathia, low set ears and peripheral pulmonary artery stenosis, patent ductus arteriosus and overlapping toes is presented for reminding this syndrome.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Fetal valproate syndrome, which is seen in children of epileptic mothers who have taken sodium valproate during their pregnancy, is characterized by typical facial appearance, major and minor malformations and neurodevelopmental delay.
📊
Key Findings & Data:Fetal valproate syndrome, which is seen in children of epileptic mothers who have taken sodium valproate during their pregnancy, is characterized by typical facial appearance, major and minor malformations and neurodevelopmental delay.
💡
Conclusion & Impact:A case with facial features including epicanthal folds, depressed nasal bridge, hypertelorism, retrognathia, low set ears and peripheral pulmonary artery stenosis, patent ductus arteriosus and overlapping toes is presented for reminding this syndrome.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Fetal valproate syndrome, which is seen in children of epileptic mothers who have taken sodium valproate during their pregnancy, is characterized by typical facial appearance, major and minor malformations and neurodevelopmental delay. A case with facial features including epicanthal folds, depressed nasal bridge, hypertelorism, retrognathia, low set ears and peripheral pulmonary artery stenosis, patent ductus arteriosus and overlapping toes is presented for reminding this syndrome.

Özet

Fetal valproat sendromu, gebeliklerinde sodyum valproat kullanan epilepsili annelerin çocuklarında görülen tipik yüz görünümü, önemli veya hafif malformasyonlar ve nöromotor gelişme geriliği ile beliren sendromdur. Epikantus, basık burun kökü, retrognati, düşük kulak ve hipertelorizmi içeren yüz bulguları, periferik pulmoner arter darlığı, patent duktus arteriyozus ve ayak parmaklarında anomali saptanan bir olgu sunulmuştur.

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Cite This Article

ÇETİNÇELİK, Ü., KALYONCU, D., ÇETİNKAYA, F. (2022). Fetal valproate syndrome. Türk Pediatri Arşivi, Cilt: 44 - Sayı: 3, 106–108. https://ajindex.com/articles/641555

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References (14)

  1. Kozma C. Valproic acid embryopathy: report of two siblings with further expantion of the phenotypic abnormalities and a review of the literature. Am J Med Genet 2001:15; 98: 168-75
  2. Malm H, Kajantie E, Kivirikko S, Kääriäinen H, Peippo M, Somer M. Valproate embryopathy in three sets of siblings: further proof of hereditary susceptibility. Neurology 2002; 59: 630-3
  3. Di Liberti JH, Farndon PA, Dennis NR, Curry CJ. The fetal valproate syndrome. Am J Med Genet 1984; 19: 473-81
  4. Clayton –Smith J, Donnai D. Fetal valproate syndrome. J Med Genet 1995; 32: 724-7
  5. Ardinger Holly H, Atkin Joan F, Blackston Dwain R, et al. Verification of the fetal valproate syndrome phenotype. Am J Med Genet 1988; 29: 171-8
  6. Kini U, Adab N, Vinten J, Fryer A, Clayton-Smith J. Dysmorphic features: an important clue to the diagnosis and severity of fetal anticonvulsant syndromes. Arch Dis Child Fetal Neonatal Ed 2006; 91: F90-5
  7. Dalens B, Raynaud EJ, Gaulme J. Teratogenicity of valproic acid. J Pediatr 1980; 97: 332-3
  8. Winter RM, Donnai D, Burn J, Tucker SM. Fetal valproate syndrome: is there a recognisable phenotype? J Med Genet 1987; 24: 692-5
  9. Briggs Gerald G, Freeman Roger K, Yaffe Sumner J. Drugs in Pregnancy and Lactation. 7th ed. Philadelphia: Lippincott Williams & Wilkins 2005: 1689-96
  10. Kulkami ML, Zaheeruddin M, Shenoy N, Vani HN. Fetal valproate syndrome. Indian J Pediatr 2006; 73: 937-9
  11. Carrim ZI, Mckay L, Sidiki SS, Lavy TE. Early intervention for the ocular and neurodevelopmental sequelae of fetal valproate syndrome. J Paediatr Child Health 2007; 43: 643-5
  12. Williams G, King J, Cunningham M, Stephan M, Kerr B, Hersh JH. Fetal valproate syndrome and autism: additional evidence of an association. Dev Med Child Neurol 2001; 43:202-6
  13. Diav-Citrin O, Shechtman S, Bar-Oz B, Cantrell D, Arnon J, Ornoy A. Pregnancy outcome after in utero exposure to valproate: evidence of dose relationship in teratogenic effect. CNS Drugs 2008; 22: 325-34
  14. Guven MA, Batukan C, Ceylaner S, Ceylaner G, Uzel M. A case of fetal anticonvulsant syndrome with severe bilateral upper limb defect. J Matern Fetal Neonatal Med 2006;19: 115-7.